18F-FDG PET in the assessment of tumor grade and prediction of tumor recurrence in intracranial meningioma

  • Jeong Won Lee
  • Keon Wook Kang
  • Sung-Hye Park
  • Sang Mi Lee
  • Jin Chul Paeng
  • June-Key Chung
  • Myung Chul Lee
  • Dong Soo Lee
Original Article

DOI: 10.1007/s00259-009-1133-x

Cite this article as:
Lee, J.W., Kang, K.W., Park, SH. et al. Eur J Nucl Med Mol Imaging (2009) 36: 1574. doi:10.1007/s00259-009-1133-x

Abstract

Purpose

The purpose of this study was to investigate the role of 18F-fluorodeoxyglucose (FDG) PET in detecting high-grade meningioma and predicting the recurrence in patients with meningioma after surgical resection.

Methods

Fifty-nine patients (27 men and 32 women) with intracranial meningioma who underwent preoperative FDG PET and subsequent surgical resection were enrolled. All patients underwent clinical follow-up for tumor recurrence with a mean duration of 34±20 months. The tumor to gray matter ratio (TGR) of FDG uptake was calculated and a receiver-operating characteristic (ROC) curve of the TGR was drawn to determine the cutoff value of the TGR for detection of high-grade meningioma. Further, univariate analysis with the log-rank test was performed to assess the predictive factors of meningioma recurrence.

Results

The TGR in high-grade meningioma (WHO grade II and III) was significantly higher than that in low-grade ones (WHO grade I) (p=0.002) and significantly correlated with the MIB-1 labeling index (r=0.338, p=0.009) and mitotic count of the tumor (r=0.284, p=0.03). The ROC analysis revealed that the TGR of 1.0 was the best cutoff value for detecting high-grade meningioma with a sensitivity of 43%, specificity of 95%, and accuracy of 81%. Of 59 patients, 5 (9%) had a recurrent event. In the log-rank test, the TGR, MIB-1 labeling index, presence of brain invasion, and WHO grade were significantly associated with tumor recurrence. The cumulative recurrence-free survival rate of patients with a TGR of 1.0 or less was significantly higher than that of patients with a TGR of more than 1.0 (p=0.0003)

Conclusion

FDG uptake in meningioma was the significant predictive factor of tumor recurrence and significantly correlated with the proliferative potential of the tumor.

Keywords

Meningioma Positron emission tomography (PET) 18F-fluorodeoxyglucose (FDG) Recurrence Prognosis 

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Jeong Won Lee
    • 1
    • 2
  • Keon Wook Kang
    • 1
    • 2
    • 3
  • Sung-Hye Park
    • 4
  • Sang Mi Lee
    • 1
  • Jin Chul Paeng
    • 1
  • June-Key Chung
    • 1
    • 2
    • 3
  • Myung Chul Lee
    • 1
    • 3
  • Dong Soo Lee
    • 1
    • 2
    • 3
  1. 1.Department of Nuclear MedicineSeoul National University College of MedicineJongno-gu, SeoulKorea
  2. 2.Cancer Research InstituteSeoul National UniversitySeoulKorea
  3. 3.Institute of Radiation MedicineSeoul National University College of MedicineSeoulKorea
  4. 4.Department of PathologySeoul National University College of MedicineSeoulKorea

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