Effects of medial temporal lobe degeneration on brain perfusion in amnestic MCI of AD type: deafferentation and functional compensation?

  • Eric Guedj
  • Emmanuel J. Barbeau
  • Mira Didic
  • Olivier Felician
  • Catherine de Laforte
  • Jean-Philippe Ranjeva
  • Michel Poncet
  • Patrick J. Cozzone
  • Olivier Mundler
  • Mathieu Ceccaldi
Original Article

DOI: 10.1007/s00259-009-1060-x

Cite this article as:
Guedj, E., Barbeau, E.J., Didic, M. et al. Eur J Nucl Med Mol Imaging (2009) 36: 1101. doi:10.1007/s00259-009-1060-x

Abstract

Purpose

Cortical atrophy is correlated with the progression of neuropathological lesions within the medial temporal lobes (MTL) in Alzheimer’s disease (AD). Our aim was to determine which local and remote functional changes result from MTL volume loss at the predementia stage.

Methods

We studied the relationship between entorhinal and hippocampal MR volumes and whole-brain SPECT perfusion via a voxel-based correlative analysis in 19 patients with amnestic mild cognitive impairment with a memory profile suggestive of early AD.

Results

Right MTL volumes were positively correlated with remote posterior perfusion of the posterior cingulate cortex, and negatively correlated with remote anterior perfusion of the right medial and dorsolateral prefrontal cortex. There was no local correlation between volumes and perfusion within the MTL.

Conclusion

These findings provide further insight into functional changes that result from MTL volume loss during the predementia stage of AD. The positive correlation between MTL volumes and posterior cingulate perfusion may reflect the deafferentation of a temporocingulate network due to mediotemporal degeneration. The paradoxical negative correlation between MTL volumes and prefrontal perfusion may result from recruitment of an alternative anterior temporofrontal network. It remains to be investigated how the “net sum” of this perfusion modulation affects memory and other cognitive domains through a possible compensatory perspective.

Keywords

MCI AD Deafferentation Functional compensation Brain SPECT SPM 

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Eric Guedj
    • 1
    • 3
    • 4
  • Emmanuel J. Barbeau
    • 5
  • Mira Didic
    • 2
    • 3
  • Olivier Felician
    • 2
    • 3
    • 6
  • Catherine de Laforte
    • 1
  • Jean-Philippe Ranjeva
    • 4
  • Michel Poncet
    • 2
    • 3
  • Patrick J. Cozzone
    • 4
  • Olivier Mundler
    • 1
  • Mathieu Ceccaldi
    • 2
    • 3
  1. 1.Service Central de Biophysique et de Médecine NucléaireCentre Hospitalo-Universitaire de la TimoneMarseille Cedex 5France
  2. 2.Service de Neurologie et de NeuropsychologieCHU TimoneMarseilleFrance
  3. 3.Laboratoire de Neurophysiologie et Neuropsychologie, Inserm U751, Faculté de MédecineUniversité de la Méditerranée Aix-Marseille IIMarseilleFrance
  4. 4.Centre de Résonance Magnétique Biologique et Médicale (CRMBM), UMR CNRS 6612, Faculté de MédecineUniversité de la Méditerranée Aix-Marseille IIMarseilleFrance
  5. 5.Centre de Recherche Cerveau et Cognition, UMR-5549CNRS – Université Paul Sabatier Toulouse 3ToulouseFrance
  6. 6.Laboratoire de Neurobiologie Intégrative et Adaptative, UMR CNRS 6149Centre Saint-CharlesMarseilleFrance

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