Dynamic perfusion patterns in temporal lobe epilepsy

  • Patrick Dupont
  • John J. ZaknunEmail author
  • Alex Maes
  • Supatporn Tepmongkol
  • Silvia Vasquez
  • C. S. Bal
  • Wim Van Paesschen
  • Silvina Carpintiero
  • Chaichon Locharernkul
  • Maurizio Dondi
Original Article



To investigate dynamic ictal perfusion changes during temporal lobe epilepsy (TLE).


We investigated 37 patients with TLE by ictal and interictal SPECT. All ictal injections were performed within 60 s of seizure onset. Statistical parametric mapping was used to analyse brain perfusion changes and temporal relationships with injection time and seizure duration as covariates.


The analysis revealed significant ictal hyperperfusion in the ipsilateral temporal lobe extending to subcortical regions. Hypoperfusion was observed in large extratemporal areas. There were also significant dynamic changes in several extratemporal regions: ipsilateral orbitofrontal and bilateral superior frontal gyri and the contralateral cerebellum and ipsilateral striatum.


The study demonstrated early dynamic perfusion changes in extratemporal regions probably involved in both propagation of epileptic activity and initiation of inhibitory mechanisms.


Perfusion imaging Network Surround inhibition Seizure cessation 



This work was conducted within the framework of a Coordinated Research Project (CRP E1.30.21) of the International Atomic Energy Agency (IAEA) and supported by IAEA contract BEL-12546.


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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Patrick Dupont
    • 1
  • John J. Zaknun
    • 2
    • 3
    Email author
  • Alex Maes
    • 1
    • 4
  • Supatporn Tepmongkol
    • 5
  • Silvia Vasquez
    • 6
  • C. S. Bal
    • 7
  • Wim Van Paesschen
    • 1
  • Silvina Carpintiero
    • 6
  • Chaichon Locharernkul
    • 5
  • Maurizio Dondi
    • 2
    • 8
  1. 1.Nuclear Medicine, Medical Imaging Center and NeurologyKU Leuven/UZ GasthuisbergLeuvenBelgium
  2. 2.Nuclear Medicine Section, Division of Human HealthInternational Atomic Energy Agency (IAEA)ViennaAustria
  3. 3.Department of Nuclear MedicineUniversity Hospital of InnsbruckInnsbruckAustria
  4. 4.Nuclear MedicineAZ GroeningeKortrijkBelgium
  5. 5.Nuclear Medicine and NeurologyChulalongkorn UniversityBangkokThailand
  6. 6.Nuclear MedicineFleni Instituto de Investigaciones NeurologicasBuenos AiresArgentina
  7. 7.Nuclear MedicineAll India Institute of Medical SciencesNew DelhiIndia
  8. 8.Nuclear MedicineOspedale MaggioreBolognaItaly

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