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Prevalence and predictors of an abnormal stress myocardial perfusion study in asymptomatic patients with type 2 diabetes mellitus

  • Arthur J. H. A. Scholte
  • Joanne D. Schuijf
  • Antje V. Kharagjitsingh
  • Petra Dibbets-Schneider
  • Marcel P. Stokkel
  • Ernst E. van der Wall
  • Jeroen J. Bax
Original Article

Abstract

Purpose

The purpose of this study was to evaluate the prevalence of an abnormal stress myocardial perfusion study in a cohort of truly asymptomatic patients with type 2 diabetes mellitus using myocardial perfusion imaging by means of single photon emission computed tomography (SPECT). Secondly, we determined which clinical characteristics may predict an abnormal stress myocardial perfusion study in this population.

Methods

A total of 120 asymptomatic patients (mean age 53±10 years) with type 2 diabetes mellitus and one or more risk factors for coronary artery disease were prospectively recruited from an outpatient diabetes clinic. All patients underwent myocardial perfusion imaging by means of adenosine 99mTc sestamibi SPECT. Images were evaluated for the presence of perfusion abnormalities as well as other nonperfusion abnormalities that may indicate extensive ischaemia, including left ventricular dysfunction (defined as a left ventricular ejection fraction <45%), transient ischaemic dilatation and adenosine-induced ST segment depression. Multivariable analysis was performed using a backward selection strategy to identify potential predictors for an abnormal stress myocardial perfusion study. Finally, all patients were followed up for 12 months to determine the occurrence of cardiovascular events: (1) cardiac death, (2) nonfatal myocardial infarction, (3) unstable angina requiring hospitalization, (4) revascularization, or (5) stroke.

Results

Of the 120 patients, 40 (33%) had an abnormal stress study, including myocardial perfusion abnormalities in 30 patients (25%). In 10 patients (8%), indicators of extensive (possibly balanced ischaemia) were observed in the absence of abnormal perfusion. The multivariable analysis identified current smoking, duration of diabetes and the cholesterol/high-density lipoprotein (HDL) ratio as independent predictors of an abnormal stress study. During a follow-up period of 12 months six patients (5%) had a cardiovascular event.

Conclusion

The current study revealed a high prevalence of abnormal stress myocardial perfusion studies in patients with type 2 diabetes mellitus despite the absence of symptoms. In contrast to earlier studies, current smoking, duration of diabetes and the cholesterol/HDL ratio were identified as independent predictors of an abnormal study.

Keywords

Diabetes mellitus Myocardial perfusion imaging SPECT 

Notes

Acknowledgment

This work was supported by an unrestricted grant from BMS Medical Imaging.

Conflicts of interest

Jeroen J. Bax has received research grants from Medtronic, Boston Scientific, St. Jude Medical & GE Healthcare. The other authors declare no conflict of interest.

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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Arthur J. H. A. Scholte
    • 1
  • Joanne D. Schuijf
    • 1
  • Antje V. Kharagjitsingh
    • 2
  • Petra Dibbets-Schneider
    • 3
  • Marcel P. Stokkel
    • 3
  • Ernst E. van der Wall
    • 1
  • Jeroen J. Bax
    • 1
  1. 1.Department of CardiologyLeiden University Medical CenterLeidenThe Netherlands
  2. 2.Department of Internal MedicineMedisch Centrum HaaglandenThe HagueThe Netherlands
  3. 3.Department of Nuclear MedicineLeiden University Medical CenterLeidenThe Netherlands

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