Positron emission tomography changes management, improves prognostic stratification and is superior to gallium scintigraphy in patients with low-grade lymphoma: results of a multicentre prospective study

  • Andrew M. Scott
  • Dishan H. Gunawardana
  • Joseph Wong
  • Ian Kirkwood
  • Rodney J. Hicks
  • Ivan Ho Shon
  • Jayne E. Ramshaw
  • Peter Robins
Original Article

Abstract

Purpose

Positron emission tomography (PET) was evaluated in low-grade non-Hodgkin lymphoma (NHL) to determine its impact on staging and management and to compare PET and gallium scans.

Methods

PET resulted in management plan changes in 74 patients with untreated low-grade NHL stages I to III. Patient outcomes to 12 months were documented.

Results

PET identified additional lesions in 50% of patients, led to a change in stage in 32%, and had a significant impact on management in 34%. Inferior progression-free survival was noted in patients with additional lesions detected by PET (p=0.001) and in the 28% of patients upstaged by PET to stage III or IV (p=0.024). In a subset of 16 patients undergoing both PET and gallium scans, PET was found to be superior.

Conclusion

PET has a major role in the management of low-grade NHL in addition to its proven role in aggressive lymphoma.

Keywords

PET Gallium Low-grade lymphoma 

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Andrew M. Scott
    • 1
    • 2
  • Dishan H. Gunawardana
    • 1
  • Joseph Wong
    • 3
  • Ian Kirkwood
    • 4
  • Rodney J. Hicks
    • 5
  • Ivan Ho Shon
    • 6
  • Jayne E. Ramshaw
    • 7
  • Peter Robins
    • 8
  1. 1.Centre for PETAustin HospitalHeidelberg, MelbourneAustralia
  2. 2.Ludwig Institute for Cancer ResearchAustin HospitalMelbourneAustralia
  3. 3.Southern X-Ray ClinicsThe Wesley HospitalBrisbaneAustralia
  4. 4.Department of Nuclear Medicine and PETRoyal Adelaide HospitalAdelaideAustralia
  5. 5.Centre for Molecular ImagingPeter MacCallum Cancer CentreMelbourneAustralia
  6. 6.Department of Nuclear Medicine & PETLiverpool HospitalSydneyAustralia
  7. 7.Australian and New Zealand Association of Physicians in Nuclear MedicineMelbourneAustralia
  8. 8.WA PET/Cyclotron ServiceSir Charles Gairdner HospitalPerthAustralia

Personalised recommendations