Thyroid uptake of 67Ga-citrate is associated with thyroid autoimmunity and hypothyroidism in patients with sarcoidosis
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To evaluate the association of gallium-67 (67Ga)-citrate thyroid uptake with the presence of thyroid disorders in patients with sarcoidosis (S patients).
Eighty-four S patients were evaluated by a complete thyroid work-up (neck ultrasound, circulating thyroid hormones and anti-thyroid antibodies, fine-needle aspiration).
In S patients with 67Ga thyroid uptake (respect those without): serum thyroid-stimulating hormone, the titre of anti-thyroid peroxidase (AbTPO) and/or anti-thyroglobulin antibodies (AbTg), and the prevalence of S patients with hypothyroidism or with positive AbTg or AbTPO was significantly higher; a thyroid hypoechoic pattern was more frequent. The prevalence of thyroid nodules was not significantly different between the two groups. Two cases of papillary thyroid cancer were observed in S patients without 67Ga thyroid uptake, whilst no case in those with 67Ga thyroid uptake.
67Ga thyroid uptake is associated with the presence of aggressive autoimmune thyroiditis and hypothyroidism in S patients; thyroid function and ultrasonography should be performed in the presence of 67Ga thyroid uptake.
Keywords67Ga-citrate scintigraphy Sarcoidosis Autoimmune thyroiditis Hypothyroidism Thyroid cancer
Conflict of interest
The authors declare no conflict of interest.
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