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Thyroid uptake of 67Ga-citrate is associated with thyroid autoimmunity and hypothyroidism in patients with sarcoidosis

  • Alessandro Antonelli
  • Piera Fazzi
  • Poupak Fallahi
  • Silvia Martina Ferrari
  • Mariano Grosso
  • Giuseppe Boni
  • Ele Ferrannini
  • Giuliano Mariani
Original Article

Abstract

Purpose

To evaluate the association of gallium-67 (67Ga)-citrate thyroid uptake with the presence of thyroid disorders in patients with sarcoidosis (S patients).

Methods

Eighty-four S patients were evaluated by a complete thyroid work-up (neck ultrasound, circulating thyroid hormones and anti-thyroid antibodies, fine-needle aspiration).

Results

In S patients with 67Ga thyroid uptake (respect those without): serum thyroid-stimulating hormone, the titre of anti-thyroid peroxidase (AbTPO) and/or anti-thyroglobulin antibodies (AbTg), and the prevalence of S patients with hypothyroidism or with positive AbTg or AbTPO was significantly higher; a thyroid hypoechoic pattern was more frequent. The prevalence of thyroid nodules was not significantly different between the two groups. Two cases of papillary thyroid cancer were observed in S patients without 67Ga thyroid uptake, whilst no case in those with 67Ga thyroid uptake.

Conclusions

67Ga thyroid uptake is associated with the presence of aggressive autoimmune thyroiditis and hypothyroidism in S patients; thyroid function and ultrasonography should be performed in the presence of 67Ga thyroid uptake.

Keywords

67Ga-citrate scintigraphy Sarcoidosis Autoimmune thyroiditis Hypothyroidism Thyroid cancer 

Notes

Conflict of interest

The authors declare no conflict of interest.

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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Alessandro Antonelli
    • 1
  • Piera Fazzi
    • 2
  • Poupak Fallahi
    • 1
  • Silvia Martina Ferrari
    • 1
  • Mariano Grosso
    • 3
  • Giuseppe Boni
    • 3
  • Ele Ferrannini
    • 1
  • Giuliano Mariani
    • 3
  1. 1.Metabolism Unit, Department of Internal MedicineUniversity of Pisa and CNR Institute of Clinical PhysiologyPisaItaly
  2. 2.Respiratory Pathophysiology Section, Cardiac and Thoracic DepartmentUniversity of PisaPisaItaly
  3. 3.Regional Center of Nuclear Medicine, Medical SchoolUniversity of PisaPisaItaly

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