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Measurement of the internal dose to families of outpatients treated with 131I for hyperthyroidism

  • S. F. BarringtonEmail author
  • P. Anderson
  • A. G. Kettle
  • R. Gadd
  • W. H. Thomson
  • S. Batchelor
  • P. J. Mountford
  • L. K. Harding
  • M. J. O’Doherty
Original Article

Abstract

Objective

The aim of this study was to measure the internal dose received by family members from ingestion of radioactive contamination after outpatient therapy.

Materials and methods

Advice was given to minimise transfer of radioiodine. Home visits were made approximately 2, 7 and 21 days after treatment to measure radioactivity in the thyroids of family members. A decay correction was applied to radioactivity detected assuming ingestion had occurred at the earlier contact time, either the day of treatment or the previous home visit. An effective half-life of 6 or 7 days was used depending on age. Thyroid activity was summed if activity was found at more than one visit in excess of the amount attributable to radioactive decay. Effective dose (ED) was calculated using ICRP72.

Results and discussion

Fifty-three adults and 92 children, median age 12 (range 4–17) years participated. Median administered activity was 576 (range 329–690) MBq 131I. Thyroid activity ranged from 0 to 5.4 kBq in the adults with activity detected in 17. Maximum adult ED was 0.4 mSv. Thyroid activity ranged from 0 to 11.8 kBq in the children with activity detected in 26. The two highest values of 5.0 and 11.8 kBq occurred in children aged 5 and 14 years from different families. Eighty-five children had no activity or <1 kBq detected. ED was <0.2 mSv in 86 out of 92 children (93%). Previous published data showed 93% of children received an ED ≤0.8 mSv from external irradiation.

Conclusion

With advice, families of outpatients receiving radioiodine should be able to comply with statutory dose limits and constraints.

Keywords

Radiation dose Radiation protection Iodine radioisotopes Thyroid gland Hyperthyroidism therapy 

Notes

Acknowledgements

This work was kindly supported by the Health and Safety Executive (HSE), UK and the Department of Health, UK. Ethical approval for the study was granted by a UK multicentre research ethics committee, and the research was carried out in accordance with UK regulations.

Conflict of interest statement

None of the authors have any potential conflict of interest to declare regarding the submission of this manuscript. The authors have had full control of all data and are happy for the journal to review original data on request.

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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • S. F. Barrington
    • 1
    Email author
  • P. Anderson
    • 2
  • A. G. Kettle
    • 3
  • R. Gadd
    • 4
  • W. H. Thomson
    • 5
  • S. Batchelor
    • 6
  • P. J. Mountford
    • 4
  • L. K. Harding
    • 5
  • M. J. O’Doherty
    • 1
  1. 1.PET Imaging CentreSt. Thomas’ HospitalLondonUK
  2. 2.Department of Nuclear MedicineQueen Elizabeth HospitalBirminghamUK
  3. 3.Department of Nuclear MedicineKent and Canterbury Hospital, East Kent Hospitals NHS TrustCanterburyUK
  4. 4.Directorate of Medical Physics and Clinical TechnologyUniversity Hospital of North StaffordshireStoke-on-TrentUK
  5. 5.Department of Physics and Nuclear MedicineCity HospitalBirminghamUK
  6. 6.Department of Medical PhysicsGuy’s and St Thomas’ HospitalLondonUK

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