Is 16-frame really superior to 8-frame gated SPECT for the assessment of left ventricular volumes and ejection fraction? Comparison of two simultaneously acquired gated SPECT studies

  • Giulia Montelatici
  • Roberto SciagràEmail author
  • Alessandro Passeri
  • Manjola Dona
  • Alberto Pupi
Original Article



Conflicting data exist about the difference between 8- and 16-frame gated single-photon emission computed tomography (SPECT) left ventricular volumes and ejection fraction (EF); moreover, the influence of framing on detection of stress-induced functional changes is unknown.


In 133 patients, two separate gated SPECT studies, one with 8 and one with 16 frames, were simultaneously acquired during a single gantry orbit using dedicated software. In 33 of 133 patients, two additional studies (with 8 and 16 frames, respectively) were acquired using arrhythmia rejection. Left ventricular EF and volumes were calculated using the QGS software. Stress-induced ischemia was identified on summed perfusion images.


Arrhythmia-rejection did not influence volumes and EF independently of framing rate. Using data without arrhythmia-rejection, there was a significant difference in volumes and EF between 8 and 16 frames both in resting and post-stress gated SPECT. However, the difference was small: 2.6% for resting and 2.8% for post-stress EF. Both using 8 and 16 frames, there were significantly larger volumes and lower EF in patients with than without stress-induced ischemia. A stress-induced decrease >5 EF units was observed in 26 of 133 patients using 8 and in 23 of 133 using 16 frames, respectively, with finding agreement in 19 patients.


Comparing two simultaneously acquired studies, the use of 16 instead of 8 frames has minor and predictable influence on functional data. Furthermore, there are no differences in the detection of stress-induced functional changes. The advantage of 16 over 8 frames in the daily clinical practice appears questionable.


Gated SPECT Left ventricular ejection fraction Left ventricular volumes Stress myocardial perfusion imaging 


Conflict of interest statement

None declared.


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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Giulia Montelatici
    • 1
  • Roberto Sciagrà
    • 1
    Email author
  • Alessandro Passeri
    • 1
  • Manjola Dona
    • 1
  • Alberto Pupi
    • 1
  1. 1.Nuclear Medicine Unit, Department of Clinical PhysiopathologyUniversity of FlorenceFlorenceItaly

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