Optimizing interventions for preventing uptake in the brown adipose tissue in FDG-PET



Brown adipose tissue FDG PET Propranolol Brown fat Diazepam Fentanyl PET-CT 



This work was supported in part by the International Union against Cancer (UICC), Geneva, Switzerland, under the ACSBI fellowship.


  1. 1.
    Hany TF, Gharehpapagh E, Kamel EM, Buck A, Himms-Hagen J, von Schulthess GK. Brown adipose tissue: a factor to consider in symmetrical tracer uptake in the neck and upper chest region. Eur J Nucl Med Mol Imaging 2002;29(10):1393–98.PubMedCrossRefGoogle Scholar
  2. 2.
    Cohade C, Osman M, Pannu HK, Wahl RL. Uptake in supraclavicular area fat (“ USA-Fat”): description on 18F-FDG PET/CT. J Nucl Med 2003;44(2):170–76.PubMedGoogle Scholar
  3. 3.
    Yeung HW, Grewal RK, Gonen M, Schoder H, Larson SM. Patterns of (18)F-FDG uptake in adipose tissue and muscle: a potential source of false-positives for PET. J Nucl Med 2003;44(11):1789–96.PubMedGoogle Scholar
  4. 4.
    Wehrli NE, Bural G, Houseni M, Alkhawaldeh K, Alavi A, Torigian DA. Determination of age-related changes in structure and function of skin, adipose tissue, and skeletal muscle with computed tomography, magnetic resonance imaging, and positron emission tomography. Semin Nucl Med 2007;37(3):195–205.PubMedCrossRefGoogle Scholar
  5. 5.
    Cohade C, Mourtzikos KA, Wahl RL. “USA-Fat”: prevalence is related to ambient outdoor temperature—evaluation with 18F-FDG PET/CT. J Nucl Med 2003;44:1267–70.PubMedGoogle Scholar
  6. 6.
    Kim S, Krynyckyi BR, Machac J, Kim CK. Temporal relation between temperature change and FDG uptake in brown adipose tissue. Eur J Nucl Med Mol Imaging. 2007 Dec 22 (in press).Google Scholar
  7. 7.
    Clarke JR, Brglevska S, Lau EW, Ramdave S, Hicks RJ. Atypical brown fat distribution in young males demonstrated on PET/CT. Clin Nucl Med 2007;32(9):679–82.PubMedCrossRefGoogle Scholar
  8. 8.
    Dobert N, Menzel C, Hamscho N, Wordehoff W, Kranert WT, Grunwald F. Atypical thoracic and supraclavicular FDG-uptake in patients with Hodgkin's and non-Hodgkin's lymphoma. Q J Nucl Med Mol Imaging 2004;48(1):33–8.PubMedGoogle Scholar
  9. 9.
    Lele RD. Fat and muscle component of body mass index (BMI): relation with hyperinsulinemia. J Assoc Phys India 2007;55:203–10.Google Scholar
  10. 10.
    Nedergaard J, Bengtsson T, Cannon B. Unexpected evidence for active brown adipose tissue in adult humans. Am J Physiol Endocrinol Metab 2007;293(2):E444–E52.PubMedCrossRefGoogle Scholar
  11. 11.
    Thackeray JT, Beanlands RS, Dasilva JN. Presence of specific 11C-meta-Hydroxyephedrine retention in heart, lung, pancreas, and brown adipose tissue. J Nucl Med 2007;48(10):1733–40.PubMedCrossRefGoogle Scholar
  12. 12.
    Baba S, Tatsumi M, Ishimori T, Lilien DL, Engles JM, Wahl RL. Effect of nicotine and ephedrine on the accumulation of 18F-FDG in brown adipose tissue. J Nucl Med 2007;48(6):981–86.PubMedCrossRefGoogle Scholar
  13. 13.
    Hadi M, Chen CC, Whatley M, Pacak K, Carrasquillo JA. Brown fat imaging with (18)F-6-fluorodopamine PET/CT, (18)F-FDG PET/CT, and (123)I-MIBG SPECT: a study of patients being evaluated for pheochromocytoma. J Nucl Med 2007;48(7):1077–83.PubMedCrossRefGoogle Scholar
  14. 14.
    Yamaga LY, Thom AF, Wagner J, Baroni RH, Hidal JT, Funari MG. The effect of catecholamines on the glucose uptake in brown adipose tissue demonstrated by (18)F-FDG PET/CT in a patient with adrenal pheochromocytoma. Eur J Nucl Med Mol Imaging. 2007 Oct 2 (in press).Google Scholar
  15. 15.
    Tatsumi M, Engles JM, Ishimori T, Nicely O, Cohade C, Wahl RL. Intense (18)F-FDG uptake in brown fat can be reduced pharmacologically. J Nucl Med 2004;45(7):1189–93.PubMedGoogle Scholar
  16. 16.
    Soderlund V, Larsson SA, Jacobsson H. Reduction of FDG uptake in brown adipose tissue in clinical patients by a single dose of propranolol. Eur J Nucl Med Mol Imaging. 2007;34(7):1018–22.PubMedCrossRefGoogle Scholar
  17. 17.
    Parysow O, Mollerach AM, Jager V, Racioppi S, San Roman J, Gerbaudo VH. Low-dose oral propranolol could reduce brown adipose tissue F-18 FDG uptake in patients undergoing PET scans. Clin Nucl Med 2007;32(5):351–57.PubMedCrossRefGoogle Scholar
  18. 18.
    Gelfand MJ, O, hara SM, Curtwright LA, Maclean JR. Pre-medication to block [(18)F]FDG uptake in the brown adipose tissue of pediatric and adolescent patients. Pediatr Radiol 2005;35(10):984–90.PubMedCrossRefGoogle Scholar
  19. 19.
    Christensen CR, Clark PB, Morton KA. Reversal of hypermetabolic brown adipose tissue in F-18 FDG PET imaging. Clin Nucl Med 2006;31(4):193–6.PubMedCrossRefGoogle Scholar
  20. 20.
    Garcia CA, Van Nostrand D, Atkins F, Acio E, Butler C, Esposito G, et al. Reduction of brown fat 2-deoxy-2-[F-18]fluoro-D-glucose uptake by controlling environmental temperature prior to positron emission tomography scan. Mol Imaging Biol 2006;8(1):24–9.PubMedCrossRefGoogle Scholar
  21. 21.
    Truong MT, Erasmus JJ, Munden RF, Marom EM, Sabloff BS, Gladish GW, et al. Focal FDG uptake in mediastinal brown fat mimicking malignancy: a potential pitfall resolved on PET/CT. AJR Am J Roentgenol 2004;183(4):1127–32.PubMedGoogle Scholar
  22. 22.
    Rousseau C, Bourbouloux E, Campion L, Fleury N, Bridji B, Chatal JF, Campone M, et al. Brown fat in breast cancer patients: analysis of serial (18)F-FDG PET/CT scans. Eur J Nucl Med Mol Imaging. 2006;33(7):785–91.PubMedCrossRefGoogle Scholar
  23. 23.
    Shimizu Y, Satoh S, Yano H, Minokoshi Y, Cushman SW, Shimazu T. Effects of noradrenaline on the cell-surface glucose transporters in cultured brown adipocytes: novel mechanism for selective activation of GLUT1 glucose transporters. Biochem J 1998;330:397–403.PubMedGoogle Scholar
  24. 24.
    Alkhawadeh K, Bural G, El-Haddad G, Houseni M, et al. Quantitative assessment of FDG uptake in brown fat using standardized uptake value and dual time point imaging. J Nucl Med 2006;47(Suppl 1):343P.Google Scholar

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  1. 1.Division of Nuclear MedicineHospital of University of PennsylvaniaPhiladelphiaUSA
  2. 2.Radiation Medicine Centre (BARC)Tata Memorial Hospital AnnexBombayIndia

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