Thyroid scintigraphy in detecting dual ectopic thyroid: A review

  • Ashwani Sood
  • Vikas Sood
  • Dev Raj Sharma
  • Rajeev K Seam
  • Rakesh Kumar
Letter to the Editor

Dear Sir,

The thyroid gland is the first endocrine gland to develop during embryogenesis on approximately 24th day of gestation. The developing thyroid is anatomically related to the developing heart, and it is pulled caudally to its definitive location in the anterior neck with the descent of heart. The thyroid completes its descent on reaching anterior to the trachea in the lower neck in the seventh gestational week. The development defects or aberrant migration of the thyroid descent will lead to ectopy of the thyroid. The Foxe 1 mutation is also shown to be associated with molecular pathology of ectopic thyroid in mouse models; however, till date, no known gene for human ectopic thyroid has been demonstrated [1]. An ectopic thyroid gland may occur anywhere along the path of initial descent of the thyroid. The most commonly found ectopic thyroid tissue is at the base of the tongue, i.e. lingual thyroid, which accounts for 90% of the reported cases. Other rare sites for ectopic...


Anterior Neck Ectopic Thyroid Euthyroid Status Thyroglossal Duct Cyst Thyroid Scintigraphy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    De Felice M, Di Lauro R. Thyroid development and its disorders: genetics and molecular mechanisms. Endocr Rev 2004;25:722-46.CrossRefPubMedGoogle Scholar
  2. 2.
    Pintar JE, Allerand CDT. Normal development of the hypothalamic-pituitary-thyroid axis. In: Braverman LE, Utigar RD, editors. Werner and Ingbar’s The Thyroid. 6th ed. Philadelphia: Lippincott; 1991. p. 11-4.Google Scholar
  3. 3.
    Long RT, Evans AM, Beggs JH. Surgical management of ectopic thyroid: report of a case with simultaneous lingual and subhyoid ectopic thyroid. Ann Surg 1964;160:824-7.CrossRefPubMedPubMedCentralGoogle Scholar
  4. 4.
    Kuehn PG, Newell RC, Reed JF. Exophthalmos in a woman with lingual sublingual and lateral lobe thyroid glands. N Engl J Med 1966;274:652-4.CrossRefPubMedGoogle Scholar
  5. 5.
    Alexandre J, Allen MW. Coexistent nontoxic lingual and median cervical ectopic thyroid: Surgical management. JAMA 1966;195:133-5.CrossRefPubMedGoogle Scholar
  6. 6.
    Ghanem N, Bley T, Altehoefer C, et al. Ectopic thyroid gland in the porta hepatis and lingua. Thyroid 2003;13:503-7.CrossRefPubMedGoogle Scholar
  7. 7.
    Hung W, Randolph JG, Sabatini D, et al. Lingual and sublingual thyroid glands in euthyroid children. Pediatrics 1966;38:647-51.PubMedGoogle Scholar
  8. 8.
    Rosen RB, Walfish PG. The subhyoid ectopic median thyroid. Can Med Assoc J. 1967;96:544-9.PubMedPubMedCentralGoogle Scholar
  9. 9.
    Meyerowitz BR, Buchholz RB. Midline cervical ectopic thyroid tissue. Surgery 1969;65:358-62.PubMedGoogle Scholar
  10. 10.
    Misaki T, Koh T, Shimbo S, et al. Dual-site thyroid ectopy in a mother and son. Thyroid 1992;2:325-7.CrossRefPubMedGoogle Scholar
  11. 11.
    Bhatnagar A, Sahu M, Ravishankar L, et al. Scintiscan demonstration of double thyroid. Clin Nucl Med 1997;22:270-1.CrossRefPubMedGoogle Scholar
  12. 12.
    Hazarika P, Siddiqui SA, Pujary K, et al. Dual ectopic thyroid: a report of two cases. J Laryngol Otol 1998;112:393-5.CrossRefPubMedGoogle Scholar
  13. 13.
    Kumar R, Khullar S, Gupta R, et al. Dual thyroid ectopy: case report and review of the literature. Clin Nucl Med 2000;25:253-4.CrossRefPubMedGoogle Scholar
  14. 14.
    Hod N, Mindlin L, Copenpour M, et al. Double ectopic thyroid. Pediatr Radiol 2002;32:859-61.CrossRefPubMedGoogle Scholar
  15. 15.
    Baik SH, Choi JH, Lee H. Dual ectpoic thyroid. Eur Arch Otorhinolaryngol 2002;259:105-7.CrossRefPubMedGoogle Scholar
  16. 16.
    Ulug T, Ulubil SA, Alagol F. Dual ectopic thyroid: report of a case. J Laryngol Otol 2003;117:574-6.CrossRefPubMedGoogle Scholar
  17. 17.
    Al-Akeely MH. Dual thyroid ectopia. Saudi Med J 2003;24:1021-3.PubMedGoogle Scholar
  18. 18.
    Kisakol G, Gonen S, Kaya A, et al. Dual ectopic thyroid gland with Graves’ disease and unilateral ophthalmopathy: a case report & review of literature. J Endocrinol Invest 2004;27:874-7.CrossRefPubMedGoogle Scholar
  19. 19.
    Bayat MR, Vawda F, Campbell H. Dual ectopic thyroid. Clin Radiol 2005;60:821-5.CrossRefPubMedGoogle Scholar
  20. 20.
    Basu S, Nair N. Dual Ectopic Thyroid. Indian Pediatr 2006;43:741. (Aug).PubMedGoogle Scholar
  21. 21.
    Chawla M, Kumar R, Malhotra A. Dual ectopic thyroid: case series and review of the literature. Clin Nucl Med 2007;32:1-5.CrossRefPubMedGoogle Scholar
  22. 22.
    Huang TS, Chen HY. Dual thyroid ectopia with a normally located pretracheal, thyroid gland: case report and review of literature. Head Neck 2007;29:885-8.CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Ashwani Sood
    • 1
  • Vikas Sood
    • 1
  • Dev Raj Sharma
    • 2
  • Rajeev K Seam
    • 1
  • Rakesh Kumar
    • 3
  1. 1.Nuclear Medicine Center, Department of Radiation TherapyIndira Gandhi Medical CollegeShimlaIndia
  2. 2.Department of ENTIndira Gandhi Medical CollegeShimlaIndia
  3. 3.Department of Nuclear MedicineAll India Institute of Medical SciencesNew DelhiIndia

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