Radioiodine treatment of hyperthyroidism: fixed or calculated doses; intelligent design or science?

  • James C. Sisson
  • Anca M. Avram
  • Domenico Rubello
  • Milton D. Gross
Letter to the Editor

Dear Sir,

All agree that radioiodine therapy will remove hyperthyroidism caused by Graves’ and toxic nodular diseases. However, therapeutic dosing of radioioidine remains controversial. Recent reports have promulgated the virtues of prescribing fixed doses of 131I [1, 2, 3]. Others have delineated the value of calculating doses based on thyroid volume and fractional concentration of the radionuclide [4, 5, 6].

Among those prescribing radioiodine therapies, there has been agreement on two principles. First, following elimination of hyperthyroidism, hypothyroidism is an almost inevitable consequence of radioiodine treatment [7]. Thus, few, if any, therapists now seek to produce euthyroidism. Second, hyperthyroidism impairs health, creates disability, and, occasionally, poses a risk to life; the disorder should be eliminated as soon as possible. A third principle has frequently been neglected in the arguments for one or the other method of therapy: radiation to the patients can have...


Hyperthyroidism Intelligent Design Propylthiouracil Thyroid Volume Antithyroid Drug 
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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • James C. Sisson
    • 1
  • Anca M. Avram
    • 1
  • Domenico Rubello
    • 2
  • Milton D. Gross
    • 1
  1. 1.Division of Nuclear Medicine, Department of RadiologyUniversity of Michigan and Department of Veterans Affairs Health SystemsAnn ArborUSA
  2. 2.Nuclear Medicine ServiceS. Maria della Misercordia HospitalRovigoItaly

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