PET recognition of pulmonary metastases on PET/CT imaging: impact of attenuation-corrected and non-attenuation-corrected PET images

  • Michael J. Reinhardt
  • Nicole Wiethoelter
  • Alexander Matthies
  • Alexius Y. Joe
  • Holger Strunk
  • Ursula Jaeger
  • Hans-Juergen Biersack
Original Article

Abstract

Purpose

The aims of this study were to assess the performance of FDG PET at PET/CT imaging for the detection of pulmonary metastases and to evaluate differences in lesion detectability on attenuation-corrected (AC) and non-attenuation corrected (NAC) PET images.

Methods

The institutional PET/CT database was searched for patients with pulmonary metastases of 3–60 mm in diameter. Ninety-two patients with 438 metastases to the lungs were included in the study. The primary tumours were 33 malignant melanomas, 12 carcinomas of unknown primary, 11 colorectal carcinomas, eight differentiated thyroid carcinomas, seven aggressive non-Hodgkin’s lymphomas, six head and neck cancers, three breast cancers, two prostate cancers and ten others. Lesion detectability was visually compared between PET and CT and between AC and NAC PET images using a five-point scale.

Results

Of the 438 pulmonary metastases, 174 were detected with FDG PET (39.7%), six of them on NAC images only (not significant). Visual scores were higher on NAC images in 41.4% and equal in 54.6% of lesions. The sensitivity of FDG PET increased significantly from 0.405 for metastases of 5–7 mm in diameter to 0.784 for lesions of 8–10 mm and to 0.935 for lesions measuring 11–29 mm in diameter. No metastases smaller than 5 mm in diameter were seen on PET images.

Conclusion

FDG PET/CT is useful for the assessment of pulmonary metastases. The frequency of lesion detection is similar for AC and NAC PET images. A reduced sensitivity of FDG PET has to be considered for lesions smaller than 11 mm in diameter.

Keywords

Positron emission tomography Computed tomography Pulmonary metastases Attenuation correction 

References

  1. 1.
    Rohren EM, Turkington TG, Coleman RE. Clinical applications of PET in oncology. Radiology 2004;231:305–32PubMedGoogle Scholar
  2. 2.
    Wahl RL. To AC or not to AC: that is the question. J Nucl Med 1999;40:2025–8PubMedGoogle Scholar
  3. 3.
    Farquhar TH, Llacer J, Hoh CK, Czernin J, Gambhir SS, Seltzer MA, et al. ROC and localization ROC analyses of lesion detection in whole-body FDG PET: effects of acquisition mode, attenuation correction and reconstruction algorithm. J Nucl Med 1999;40:2043–52PubMedGoogle Scholar
  4. 4.
    Kinahan PE, Townsend DW, Beyer T, Sashin D. Attenuation correction for a combined 3D PET/CT scanner. Med Phys 1998;25:2046–53CrossRefPubMedGoogle Scholar
  5. 5.
    Townsend DW, Beyer T, Blodgett TM. PET/CT scanners: a hardware approach to image fusion. Semin Nucl Med 2003;33:193–204CrossRefPubMedGoogle Scholar
  6. 6.
    Kinahan PE, Hasegawa BH, Beyer T. X-ray-based attenuation correction for positron emission tomography/computed tomography scanners. Semin Nucl Med 2003;33:166–79CrossRefPubMedGoogle Scholar
  7. 7.
    Vansteenkiste JF, Stroobants SG. The role of positron emission tomography with 18F-fluoro-2-deoxy-D-glucose in respiratory oncology. Eur Respir J 2001;17:808–20CrossRefGoogle Scholar
  8. 8.
    Zatz LM, Alvarez RE. An inaccuracy in computed tomography: the energy dependence of CT values. Radiology 1977;124:91–7PubMedGoogle Scholar
  9. 9.
    Beyer T, Antoch G, Blodgett T, Freudenberg LF, Akhurst T, Mueller S. Dual-modality PET/CT imaging: the effect of respiratory motion on combined image quality in clinical oncology. Eur J Nucl Med Mol Imaging 2003;30:588–96PubMedGoogle Scholar
  10. 10.
    Watson CC, Newport D, Casey ME. A single scatter simulation technique for scatter correction in 3D PET. In: Grangeat P, Amans JL, editors. Computational imaging and vision. Dordrecht, The Netherlands: Kluwer Academic Press; 1996. pp 255–68Google Scholar
  11. 11.
    Defrise M, Kinahan PE, Townsend DW, Michel C, Sibomana M, Newport DF. Exact and approximate rebinning algorithms for 3D PET data. IEEE Trans Med Imaging 1997;16:145–58CrossRefPubMedGoogle Scholar
  12. 12.
    Hudson HM, Larkin RS. Accelerated image reconstruction using ordered subsets of projection data. IEEE 1994;13:601–9CrossRefGoogle Scholar
  13. 13.
    Ost D, Fein AM, Feinsilver SH. The solitary pulmonary nodule. N Engl J Med 2003;348:2535–42CrossRefPubMedGoogle Scholar
  14. 14.
    Gould MK, Maclean CC, Kuschner WG, Rydzak CE, Owens DK. Accuracy of positron emission tomography for diagnosis of pulmonary nodules and mass lesions. A meta-analysis. JAMA 2001;285:914–24CrossRefPubMedGoogle Scholar
  15. 15.
    Dewan NA, Shehan CJ, Reeb SD, Gobar LS, Scott WJ, Ryschon K. Likelihood of malignancy in a solitary pulmonary nodule. Chest 1997;112:416–22PubMedGoogle Scholar
  16. 16.
    Nomori H, Watanabe K, Ohtsuka T, Naruke T, Suemasu K, Uno K. Evaluation of F-18 fluorodeoxyglucose (FDG) PET scanning for pulmonary nodules less than 3 cm in diameter with special reference to the CT images. Lung Cancer 2004;45:19–27CrossRefPubMedGoogle Scholar
  17. 17.
    Beyer T, Townsend DW, Brun T, Kinahan PE, Charron M, Roddy R, et al. A combined PET/CT scanner for clinical oncology. J Nucl Med 2000;41:1369–79PubMedGoogle Scholar
  18. 18.
    Bengel FM, Ziegler SI, Avril N, Weber W, Laubenbacher C, Schwaiger M. Whole-body positron emission tomography in clinical oncology: comparison between attenuation-corrected and uncorrected images. Eur J Nucl Med 1997;24:1091–8PubMedGoogle Scholar
  19. 19.
    Imran MB, Kubota K, Yamada S, Fukuda H, Yamada K, Fujiwara T, et al. Lesion-to-background ratio in nonattenuation-corrected whole-body FDG PET images. J Nucl Med 1998;39:1219–23PubMedGoogle Scholar
  20. 20.
    Bleckmann C, Dose J, Bohuslavizki KH, Buchert R, Klutmann S, Mester J, et al. Effect of attenuation correction on lesion detectability in FDG PET of breast cancer. J Nucl Med 1999;40:2021–4PubMedGoogle Scholar
  21. 21.
    Kotzerke J, Guhlmann A, Moog F, Frickhofen N, Reske SN. Role of attenuation correction for fluorine-18 fluorodeoxyglucose positron emission tomography in the primary staging of malignant lymphoma. Eur J Nucl Med 1999;26:31–8CrossRefPubMedGoogle Scholar
  22. 22.
    Skehan SJ, Coates G, Otero C, O’Donovan N, Pelling M, Nahmias C. Visual and semiquantitative analysis of 18F-fluorodeoxyglucose positron emission tomography using a partial-ring tomograph without attenuation correction to differentiate benign and malignant pulmonary nodules. Can Assoc Radiol J 2001;52:259–65PubMedGoogle Scholar
  23. 23.
    Raylman RR, Kison PV, Wahl RL. Capabilities of two- and three-dimensional FDG-PET for detecting small lesions and lymph nodes in the upper torso: a dynamic phantom study. Eur J Nucl Med 1999;26:39–45CrossRefPubMedGoogle Scholar
  24. 24.
    Bai C, Kinahan PE, Brasse D. An analytic study of the effects of attenuation on tumor detection in whole-body PET oncology imaging. J Nucl Med 2003;44:1855–61PubMedGoogle Scholar
  25. 25.
    Erdi YE, Nehmeh SA, Pan T, Pevsner A, Rosenzweig KE, Mageras G, et al. The CT motion quantitation of lung lesions and its impact on PET-measured SUVs. J Nucl Med 2004;45:1287–92PubMedGoogle Scholar
  26. 26.
    Goerres GW, Burger C, Kamel E, Seifert B, Kaim AH, Buck A, et al. Respiration-induced attenuation artifact at PET/CT: technical considerations. Radiology 2003;226:906–10PubMedGoogle Scholar
  27. 27.
    Goerres GW, Kamel E, Seifert B, Burger C, Buck A, Hany TF, et al. Accuracy of image coregistration of pulmonary lesions in patients with non-small cell lung cancer using an integrated PET/CT system. J Nucl Med 2002;43:1469–75PubMedGoogle Scholar
  28. 28.
    Goerres GW, Kamel E, Heidelberg TNH, Schwitter M, Burger C, von Schulthess GK. PET-CT images coregistration in the thorax: influence of respiration. Eur J Nucl Med Mol Imaging 2002;29:351–60CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Michael J. Reinhardt
    • 1
  • Nicole Wiethoelter
    • 1
  • Alexander Matthies
    • 1
  • Alexius Y. Joe
    • 1
  • Holger Strunk
    • 2
  • Ursula Jaeger
    • 2
  • Hans-Juergen Biersack
    • 1
  1. 1.Department of Nuclear MedicineUniversity Hospital BonnBonnGermany
  2. 2.Department of RadiologyUniversity Hospital BonnBonnGermany

Personalised recommendations