Effect of colony-stimulating factor and conventional- or high-dose chemotherapy on FDG uptake in bone marrow

  • Toshiki Kazama
  • Nancy Swanston
  • Donald A. Podoloff
  • Homer A. Macapinlac
Original Article

DOI: 10.1007/s00259-005-1890-0

Cite this article as:
Kazama, T., Swanston, N., Podoloff, D.A. et al. Eur J Nucl Med Mol Imaging (2005) 32: 1406. doi:10.1007/s00259-005-1890-0

Abstract

Purpose

Granulocyte or granulocyte-macrophage colony stimulating factor (CSF), usually used in conjunction with chemotherapy, may interfere with the 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) reading. The purpose of this study is to evaluate the effects of CSF, conventional-or high-dose chemotherapy on bone marrow FDG uptake.

Methods

Two hundred and forty-one FDG PET scans obtained in 163 patients with lymphoma and no pathologically and radiologically proven bone marrow involvement were analyzed. The standardized uptake value (SUV) of each patient’s spine was measured.

Results

Among patients with no recent history of CSF use, the average SUV in 36 patients with no history of chemotherapy was 1.60±0.34, that in 49 patients with a history of conventional-dose chemotherapy was 1.37±0.32, and that in 12 patients with a history of high-dose chemotherapy was 1.26±0.25 (P=0.008 and 0.002, respectively by Mann-Whitney U test). In 80 patients treated with conventional-dose chemotherapy and CSF, the average SUV after discontinuation of CSF was as follows: 0–7 days, 2.37±1.19; 8–14 days: 2.04±0.67; 15–21 days: 1.87±0.52; 22–30 days: 1.59±0.18; 31–90 days: 1.54±0.36. In 45 patients treated with high-dose chemotherapy and CSF, no significant increase in bone marrow uptake was seen in most of them.

Conclusion

Bone marrow FDG uptake may be increased by CSF treatment and may be decreased by chemotherapy. In patients treated with conventional-dose chemotherapy and CSF, increased marrow uptake will return to the pretreatment value approximately 1 month after discontinuation of CSF.

Keywords

18 F‐FDG‐PET Lymphoma Oncology Bone Therapy 

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Toshiki Kazama
    • 1
    • 2
  • Nancy Swanston
    • 1
  • Donald A. Podoloff
    • 1
  • Homer A. Macapinlac
    • 1
  1. 1.Division of Diagnostic ImagingThe University of Texas M.D. Anderson Cancer CenterHoustonUSA
  2. 2.Department of RadiologyChiba University HospitalChibaJapan

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