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The role of 18F-FDG PET in characterising disease activity in Takayasu arteritis

  • Myles Webb
  • Anthony Chambers
  • Adil AL-Nahhas
  • Justin C. Mason
  • Lucy Maudlin
  • Lucy Rahman
  • John Frank
Original Article

Abstract

Takayasu arteritis (TA) is a rare, sporadic and chronic inflammatory arteritis, which predominantly affects the aorta and its branches. Diagnosis can be difficult and there are limitations to the current diagnostic work-up. By detecting areas of active glucose metabolism present in active vasculitis, imaging with fluorine-18 fluorodeoxyglucose positron emission tomography (18F-FDG PET) could potentially have a role in the management of TA. Our aim was to assess this role by reviewing 28 18F-FDG PET scans performed on 18 patients suspected of having TA. All patients had full clinical and laboratory assessment, cross-sectional imaging and angiography, and 16/18 satisfied the American College of Rheumatologists’ criteria for TA. 18F-FDG PET achieved a sensitivity of 92%, a specificity of 100%, and negative and positive predictive values of 85% and 100% respectively in the initial assessment of active vasculitis in TA. We conclude that 18F-FDG PET can be used to diagnose early disease, to detect active disease (even within chronic changes) and to monitor the effectiveness of treatment.

Keywords

18F-FDG PET Takayasu arteritis Angiography MRA Immunosuppression 

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Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • Myles Webb
    • 1
  • Anthony Chambers
    • 1
  • Adil AL-Nahhas
    • 1
  • Justin C. Mason
    • 2
  • Lucy Maudlin
    • 1
  • Lucy Rahman
    • 1
  • John Frank
    • 1
  1. 1.Department of Nuclear MedicineHammersmith HospitalLondonUnited Kingdom
  2. 2.Department of RheumatologyHammersmith HospitalLondonUnited Kingdom

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