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Complementary alternative medicine and nuclear medicine

  • Ursula Werneke
  • V. Ralph McCreadyEmail author
Occasional Survery
  • 79 Downloads

Abstract

Complementary alternative medicines (CAMs), including food supplements, are taken widely by patients, especially those with cancer. Others take CAMs hoping to improve fitness or prevent disease. Physicians (and patients) may not be aware of the potential side-effects and interactions of CAMs with conventional treatment. Likewise, their known physiological effects could interfere with radiopharmaceutical kinetics, producing abnormal treatment responses and diagnostic results. Nuclear medicine physicians are encouraged to question patients on their intake of CAMs when taking their history prior to radionuclide therapy or diagnosis. The potential effect of CAMs should be considered when unexpected therapeutic or diagnostic results are found.

Keywords

Alternative Complementary Therapy Diagnosis Interaction 

Notes

Acknowledgements

We are grateful to Adrian Hall and Rob Williams for their comments and suggestions.

References

  1. 1.
    Werneke U, Earl J, Seydel C, Horn O, Crichton P, Fannon D: Potential health risks of complementary alternative medicines in cancer patients. Br J Cancer. In press.Google Scholar
  2. 2.
    Ernst E. Herbal medicines put into context. BMJ 2003; 327:881–882.CrossRefPubMedGoogle Scholar
  3. 3.
    Fugh-Berman A. Herb-drug interactions. Lancet 2000; 355:134–138.PubMedGoogle Scholar
  4. 4.
    Izzo AA, Ernst E. Interactions between herbal medicines and prescribed drugs: a systematic review. Drugs 2001; 61:2163–2175.PubMedGoogle Scholar
  5. 5.
    Food Standards Agency: Expert Group on Vitamins and Minerals. Safe upper levels for vitamins and minerals. 2003. www.foodstandards.gov.uk.Google Scholar
  6. 6.
    Natural lithium. 2003. http://www.findserenitynow.comGoogle Scholar
  7. 7.
    Lazarus JH. The effects of lithium therapy on thyroid and thyrotropin-releasing hormone. Thyroid 1998; 8:909–913.PubMedGoogle Scholar
  8. 8.
    Bal CS, Kumar A, Pandey RM. A randomized controlled trial to evaluate the adjuvant effect of lithium on radioiodine treatment of hyperthyroidism. Thyroid 2002; 12:399–405.CrossRefPubMedGoogle Scholar
  9. 9.
    Caykoylu A, Capoglu I, Unuvar N, Erdem F, Cetinkaya R. Thyroid abnormalities in lithium-treated patients with bipolar affective disorder. J Int Med Res 2002; 30:80–84.PubMedGoogle Scholar
  10. 10.
    Clark LC, Combs GF Jr, Turnbull BW, et al. Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group. JAMA 1996; 276:1957–1963.PubMedGoogle Scholar
  11. 11.
    Clark LC, Dalkin B, Krongrad A, et al. Decreased incidence of prostate cancer with selenium supplementation: results of a double-blind cancer prevention trial. Br J Urol 1998; 81:730–734.CrossRefPubMedGoogle Scholar
  12. 12.
    Rayman MP. The importance of selenium to human health. Lancet 2000; 356:233–241.PubMedGoogle Scholar
  13. 13.
    Fu Y, Matta SG, Sharp BM. Local alpha-bungarotoxin-sensitive nicotinic receptors modulate hippocampal norepinephrine release by systemic nicotine. J Pharmacol Exp Ther 1999; 289:133–139.PubMedGoogle Scholar
  14. 14.
    Gallardo KA, Leslie FM. Nicotine-stimulated release of [3H]norepinephrine from fetal rat locus coeruleus cells in culture. J Neurochem 1998; 70:663–670.PubMedGoogle Scholar
  15. 15.
    Rao TS, Correa LD, Lloyd GK. Effects of lobeline and dimethylphenylpiperazinium iodide (DMPP) on N-methyl-d-aspartate (NMDA)-evoked acetylcholine release in vitro: evidence for a lack of involvement of classical neuronal nicotinic acetylcholine receptors. Neuropharmacology 1997; 36:39–50.CrossRefPubMedGoogle Scholar
  16. 16.
    White HL, Scates PW, Cooper BR. Extracts of ginkgo biloba leaves inhibit monoamine oxidase. Life Sci 1996; 58:1315–1321.PubMedGoogle Scholar
  17. 17.
    Markstein R. Hydergine: interaction with the neurotransmitter systems in the central nervous system. J Pharmacol 1985; 16 Suppl 3:1–17.Google Scholar
  18. 18.
    Itoh T, Zang YF, Murai S, Saito H. Effects of Panax ginseng root on the vertical and horizontal motor activities and on brain monoamine-related substances in mice. Planta Med 1989; 55:429–433.PubMedGoogle Scholar
  19. 19.
    Zhang Y, Saito H, Nishiyama N, Abe K. Effects of DX-9386, a traditional Chinese medicinal prescription, on long-term potentiation in the dentate gyrus in rats. Biol Pharm Bull 1994; 17:1337–1340.PubMedGoogle Scholar
  20. 20.
    Whiskey E, Werneke U, Taylor D. A systematic review and meta-analysis of Hypericum perforatum in depression: a comprehensive clinical review. Int Clin Psychopharmacol 2001; 16:239–252.CrossRefPubMedGoogle Scholar
  21. 21.
    Taylor JE. Neuromediator binding to receptors in the rat brain. The effect of chronic administration of Ginkgo biloba extract [in French]. Presse Med 1986; 15:1491–1493.PubMedGoogle Scholar
  22. 22.
    Lewis R, Wake G, Court G, et al. Non-ginsenoside nicotinic activity in ginseng species. Phytother Res 1999; 13:59–64.CrossRefPubMedGoogle Scholar
  23. 23.
    Amenta F, Cavallotti C, Franch F, Ricci A. Muscarinic cholinergic receptors in the hippocampus of the aged rat: effects of long-term hydergine administration. Arch Int Pharmacodyn Ther 1989; 297:225–234.PubMedGoogle Scholar
  24. 24.
    Naito T, Itoh H, Nagano T, Takeyama M. Effects of Ninjin-to on levels of brain-gut peptides (motilin, vasoactive intestinal peptide, gastrin, and somatostatin) in human plasma. Biol Pharm Bull 2001; 24:194–196.CrossRefPubMedGoogle Scholar
  25. 25.
    Naito T, Itoh H, Yasunaga F, Takeyama M. Rikkunshi-to raises levels of somatostatin and gastrin in human plasma. Biol Pharm Bull 2001; 24:841–843.CrossRefPubMedGoogle Scholar
  26. 26.
    Naito T, Itoh H, Yasunaga F, Takeyama M. Hange-shashin-to raises levels of somatostatin, motilin, and gastrin in the plasma of healthy subjects. Biol Pharm Bull 2002; 25:327–331.CrossRefPubMedGoogle Scholar
  27. 27.
    Mori K, Kondo T, Kamiyama Y, Kano Y, Tominaga K. Preventive effect of Kampo medicine (Hangeshashin-to) against irinotecan-induced diarrhea in advanced non-small-cell lung cancer. Cancer Chemother Pharmacol 2003; 51:403–406.PubMedGoogle Scholar
  28. 28.
    You SY, Wu XZ, Liu ML. Effects of dachengqi decoction on gut hormones and intestinal movement after cholecystectomy [in Chinese]. Zhongguo Zhong Xi Yi Jie He Za Zhi 1994; 14:522–524.PubMedGoogle Scholar
  29. 29.
    Gong Z, Yuan Y, Lou K, Tu S, Zhai Z, Xu J. Mechanisms of Chinese herb emodin and somatostatin analogs on pancreatic regeneration in acute pancreatitis in rats. Pancreas 2002; 25:154–160.CrossRefPubMedGoogle Scholar
  30. 30.
    Ren P, Huang X, Zhang L. Effect of sijunzi decoction on gastric emptying rate in rat model of spleen deficiency syndrome [in Chinese]. Zhongguo Zhong Xi Yi Jie He Za Zhi 2000; 20:596–598.PubMedGoogle Scholar
  31. 31.
    Blake GM, Lewington VJ, Zivanovic MA, Ackery DM. Glomerular filtration rate and the kinetics of123I-metaiodobenzylguanidine. Eur J Nucl Med 1989; 15:618–623.PubMedGoogle Scholar
  32. 32.
    Mouser JF, Hak EB, Helms RA, Christensen ML, Storm MC. Chromium and zinc concentrations in pediatric patients receiving long-term parenteral nutrition. Am J Health Syst Pharm 1999; 56:1950–1956.PubMedGoogle Scholar
  33. 33.
    Bendz H, Aurell M, Lanke J. A historical cohort study of kidney damage in long-term lithium patients: continued surveillance needed. Eur Psychiatry 2001; 16:199–206.CrossRefPubMedGoogle Scholar
  34. 34.
    Newall CA, Anderson LA, Philpson JD. Herbal medicine: a guide for healthcare professionals. London: The Pharmaceutical, 1996.Google Scholar
  35. 35.
    Watanabe G, Tomiyama H, Doba N. Effects of oral administration ofl-arginine on renal function in patients with heart failure. J Hypertens 2000; 18:229–234.CrossRefPubMedGoogle Scholar
  36. 36.
    Robbers JE, Tyler VE. Tyler’s herbs of choice: the therapeutic use of phytomedicinals. New York: The Haworth Herbal Press, 1999.Google Scholar
  37. 37.
    Levine M, Rumsey SC, Daruwala R, Park JB, Wang Y. Criteria and recommendations for vitamin C intake. JAMA 1999; 281:1415–1423.CrossRefPubMedGoogle Scholar
  38. 38.
    Lehmann-Willenbrock E, Riedel HH. Clinical and endocrinologic studies of the treatment of ovarian insufficiency manifestations following hysterectomy with intact adnexa [in German]. Zentralbl Gynakol 1988; 110:611–618.PubMedGoogle Scholar
  39. 39.
    Komesaroff PA, Black CV, Cable V, Sudhir K. Effects of wild yam extract on menopausal symptoms, lipids and sex hormones in healthy menopausal women. Climacteric 2001; 4:144–150.PubMedGoogle Scholar
  40. 40.
    Pino AM, Valladares LE, Palma MA, Mancilla AM, Yanez M, Albala C. Dietary isoflavones affect sex hormone-binding globulin levels in postmenopausal women. J Clin Endocrinol Metab 2000; 85:2797–2800.PubMedGoogle Scholar
  41. 41.
    Hiller KO, Zetler G. Neuropharmacological studies on ethanol extracts of Valeriana officialis L.: behavioural and anticonvulsant properties. Phytother Res 1996; 10:224–230.CrossRefGoogle Scholar
  42. 42.
    Jussofie A, Schmiz A, Hiemke C. Kavapyrone enriched extract from Piper methysticum as modulator of the GABA binding site in different regions of rat brain. Psychopharmacology (Berl) 1994; 116:469–474.Google Scholar
  43. 43.
    Brauer RB, Stangl M, Stewart JR, Pfab R, Becker K. Acute liver failure after administration of herbal tranquilizer kava-kava (Piper methysticum). J Clin Psychiatry 2003; 64:216–218.PubMedGoogle Scholar
  44. 44.
    Escher M, Desmeules J, Giostra E, Mentha G. Hepatitis associated with Kava, a herbal remedy for anxiety. BMJ 2001; 322:139.CrossRefPubMedGoogle Scholar
  45. 45.
    Humberston CL, Akhtar J, Krenzelok EP. Acute hepatitis induced by kava kava. J Toxicol Clin Toxicol 2003; 41:109–113.CrossRefPubMedGoogle Scholar
  46. 46.
    Russmann S, Lauterburg BH, Helbling A. Kava hepatotoxicity. Ann Intern Med 2001; 135:68–69.PubMedGoogle Scholar
  47. 47.
    Zheng XM, Williams RC. Serum caffeine levels after 24-hour abstention: clinical implications on dipyridamole (201)Tl myocardial perfusion imaging. J Nucl Med Technol 2002; 30:123–127.PubMedGoogle Scholar
  48. 48.
    Hay AJ, Hamburger M, Hostettmann K, Hoult JR. Toxic inhibition of smooth muscle contractility by plant-derived sesquiterpenes caused by their chemically reactive alpha-methylenebutyrolactone functions. Br J Pharmacol 1994; 112:9–12.PubMedGoogle Scholar
  49. 49.
    Kivisto KT, Kroemer HK, Eichelbaum M. The role of human cytochrome P450 enzymes in the metabolism of anticancer agents: implications for drug interactions. Br J Clin Pharmacol 1995; 40:523–530.PubMedGoogle Scholar
  50. 50.
    Wang W, Sonders MS, Ukairo OT, Scott H, Kloetzel MK, Surratt CK. Dissociation of high-affinity cocaine analog binding and dopamine uptake inhibition at the dopamine transporter. Mol Pharmacol 2003; 64:430–439.CrossRefPubMedGoogle Scholar
  51. 51.
    Szumlinski KK, Maisonneuve IM, Glick SD. The potential anti-addictive agent, 18-methoxycoronaridine, blocks the sensitized locomotor and dopamine responses produced by repeated morphine treatment. Brain Res 2000; 864:13–23.CrossRefPubMedGoogle Scholar
  52. 52.
    Glick SD, Kuehne ME, Raucci J, et al. Effects of iboga alkaloids on morphine and cocaine self-administration in rats: relationship to tremorigenic effects and to effects on dopamine release in nucleus accumbens and striatum. Brain Res 1994; 657:14–22.CrossRefPubMedGoogle Scholar
  53. 53.
    Waumans D, Bruneel N, Tytgat J. Anise oil as para-methoxyamphetamine (PMA) precursor. Forensic Sci Int 2003; 133:159–170.CrossRefPubMedGoogle Scholar
  54. 54.
    Reading SA. Chromium picolinate. J Fla Med Assoc 1996; 83:29–31.PubMedGoogle Scholar
  55. 55.
    Tunnicliff G. Sites of action of gamma-hydroxybutyrate (GHB)—a neuroactive drug with abuse potential. J Toxicol Clin Toxicol 1997; 35:581–590.PubMedGoogle Scholar
  56. 56.
    Tunnicliff G. Significance of gamma-hydroxybutyric acid in the brain. Gen Pharmacol 1992; 23:1027–1034.CrossRefPubMedGoogle Scholar
  57. 57.
    Maitre M. The gamma-hydroxybutyrate signalling system in brain: organization and functional implications. Prog Neurobiol 1997; 51:337–361.CrossRefPubMedGoogle Scholar
  58. 58.
    Muller WE, Singer A, Wonnemann M, Hafner U, Rolli M, Schafer C. Hyperforin represents the neurotransmitter reuptake inhibiting constituent of hypericum extract. Pharmacopsychiatry 1998; 31 Suppl 1:16–21.Google Scholar
  59. 59.
    Jensen AG, Hansen SH, Nielsen EO. Adhyperforin as a contributor to the effect of Hypericum perforatum L. in biochemical models of antidepressant activity. Life Sci 2001; 68:1593–1605.PubMedGoogle Scholar
  60. 60.
    Bom HS, Lim SC, Kim YC, Song HC, Min JJ, Jeong HJ et al. Dipyridamole modulated Tc-99m sestamibi lung SPECT in small cell lung cancer. Clin Nucl Med 1999; 24:97–101.CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  1. 1.Institute of PsychiatryKing’s CollegeLondonUK
  2. 2.Royal Marsden HospitalSuttonUK

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