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Does diabetes affect [18F]FDG standardised uptake values in lung cancer?

  • Miguel Gorenberg
  • William A. Hallett
  • Michael J. O'Doherty
Original Article

Abstract.

The correlation of hyperglycaemia with decreased 2-[18F]fluoro-2-deoxy-D-glucose (FDG) uptake by tumours in positron emission tomography (PET) imaging has been clearly established. The available data are mainly based on non-diabetic (non-DM) patients exposed to acute hyperglycaemia after glucose infusion, and little is known about the effect of diabetes mellitus (DM) on FDG uptake by tumours. In this retrospective study we performed a comparison of the tumour uptake in 40 DM patients with the tumour uptake in 145 non-DM patients, all with primary lung malignancies. Peak standardised uptake values (SUVs) without glucose correction were calculated for the lung lesions. Mean (±standard deviation) blood glucose concentrations were 6.58±2.46 mmol/l in the DM patients and 4.39±0.89 mmol/l in the non-DM patients. There was no significant difference between tumour SUVs in DM patients (79 lesions), 5.86±3.97, and those in non-DM patients (234 lesions), 6.47±4.61. There was no significant difference between tumour SUVs in DM patients with blood glucose <7 mmol/l (n=28, 64 lesions), 5.91±3.98, and those in DM patients with blood glucose >7 mmol/l (n=12, 15 lesions), 5.68±4.09. There was also no significant difference between myocardial SUVs in the DM patients (n=40), 3.28±2.75, and in a similar group of non-DM patients (n=42), 3.30±2.24. We conclude that FDG uptake in lung tumours is not significantly influenced by blood glucose levels in diabetic patients whose blood glucose levels are reasonably well controlled.

Positron emission tomography 2-[18F]fluoro-2-deoxy-D-glucose Lung cancer Diabetes Standardised uptake value 

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Copyright information

© Springer-Verlag 2002

Authors and Affiliations

  • Miguel Gorenberg
    • 1
  • William A. Hallett
    • 2
  • Michael J. O'Doherty
    • 2
  1. 1.Department of Nuclear Medicine, Rebecca Sieff Government Hospital, SafedIsrael
  2. 2.The Clinical PET Centre, Guy's, King's and St Thomas' School of Medicine, St Thomas' Hospital, Lambeth Palace Road, London SE1 7EHUK

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