Sarcoma tumor FDG uptake measured by PET and patient outcome: a retrospective analysis

  • Janet F. Eary
  • Finbarr O'Sullivan
  • Yudi Powitan
  • Kingshuk Chandhury
  • Cheryl Vernon
  • James D. Bruckner
  • Ernest U. Conrad
Original Article

Abstract.

In a retrospective analysis of patients with sarcoma who underwent fluorodeoxyglucose positron emission tomography (FDG PET) imaging, tumor maximum FDG uptake was analyzed for ability to predict patient survival and disease-free interval. Two hundred and nine patients with sarcoma were imaged prior to treatment with neoadjuvant chemotherapy or resection. Tumor FDG uptake expressed as maximum standard uptake value (SUVmax) was compared with disease-free and overall survival. A multivariate Cox regression analysis was applied to examine the role of SUVmax in predicting time to death or disease progression, after adjusting for standard clinical prognostic factors. The multivariate analyses showed that the SUVmax information is a statistically significant independent predictor of patient survival. Tumors with larger SUVmax have a significantly poorer prognosis. This retrospective analysis indicates that the sarcoma tumor SUVmax value determined by PET is an independent predictor of survival and disease progression.

Sarcoma FDG PET SUVmax Disease-free interval Survival 

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Copyright information

© Springer-Verlag 2002

Authors and Affiliations

  • Janet F. Eary
    • 1
  • Finbarr O'Sullivan
    • 2
  • Yudi Powitan
    • 2
  • Kingshuk Chandhury
    • 2
  • Cheryl Vernon
    • 1
  • James D. Bruckner
    • 3
  • Ernest U. Conrad
    • 3
  1. 1.University of Washington Medical Center, Division of Nuclear Medicine, Box 356113, Seattle WA 98195-6113, Washington, USAUSA
  2. 2.University College, Department of Statistics, Cork, IrelandIreland
  3. 3.University of Washington Medical Center, Department of Orthopedics, Seattle, Washington, USAUSA

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