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European Journal of Nuclear Medicine

, Volume 28, Issue 12, pp 1776–1780 | Cite as

Accuracy of technetium-99m sestamibi scintimammography and X-ray mammography in premenopausal women with suspected breast cancer

  • Franco Lumachi
  • Guido Ferretti
  • Michele Povolato
  • Maria Marzola
  • Pietro Zucchetta
  • Onelio Geatti
  • Alba A. Brandes
  • Franco Bui
Original Article

Abstract

The aim of this study was to evaluate the usefulness of technetium-99m sestamibi scintimammography (SSM) and combined use of SSM and X-ray mammography (MG) in premenopausal patients with small (≤2 cm) suspicious breast lesions. Eighty-seven premenopausal women (median age 47 years, range 32–52) with breast lesions ranging from 4 to 20 mm in greatest diameter (median 12 mm) and detected by MG, underwent SSM prior to open breast biopsy. A planar camera and single-photon emission tomography (SPET) technique were used in 23 (26.4%) and 64 (73.6%) patients, respectively. At histological examination, 72 (82.8%) breast cancers (pT1a=3, pT1b=27, pT1c=42) and 15 (17.2%) benign masses were found. Sensitivity, specificity, positive predictive value, negative predictive value and accuracy of MG and SSM were 80.6% vs 80.6%, 60.0% vs 93.3% (P<0.05), 90.6% vs 98.3%, 39.1% vs 50.0% and 77.0% vs 82.8%, respectively. MG + SSM together had a sensitivity of 94.4% (P<0.05 vs SSM alone) and an accuracy of 82.8% for the detection of breast cancer. Tumours undetected by both MG and SSM were significantly (P<0.05) smaller than those correctly diagnosed. Patients with false-negative MG were younger (P<0.05) than those with tumours correctly detected, while SSM sensitivity was independent (P=NS) of age. In conclusion, in premenopausal patients with small breast lesions, the sensitivity of SSM and MG is similar (P=NS), whereas the specificity of SSM is significantly higher (P<0.05) than that of MG. Furthermore, the combination of MG and SSM offers significantly improved sensitivity and accuracy in comparison with the individual techniques, suggesting a complementary role of SSM in the detection of breast cancer in younger patients.

Scintimammography Mammography Breast cancer Premenopausal women Diagnosis 

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Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  • Franco Lumachi
    • 1
  • Guido Ferretti
    • 4
  • Michele Povolato
    • 4
  • Maria Marzola
    • 2
  • Pietro Zucchetta
    • 2
  • Onelio Geatti
    • 4
  • Alba A. Brandes
    • 3
  • Franco Bui
    • 2
  1. 1.Endocrine Surgery Unit, Department of Surgical and Gastroenterological Sciences, University of Padua, Medical School, via Giustiniani 2, 35128 PadovaItaly
  2. 2.Nuclear Medicine Service, Department of Diagnostic Medical Sciences, University of Padua, Medical School, 35128 PadovaItaly
  3. 3.Division of Medical Oncology, Azienda Ospedaliera, 35128 PadovaItaly
  4. 4.Nuclear Medicine Service, Ospedali Riuniti, 34100 TriesteItaly

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