Skeletal Radiology

, Volume 27, Issue 2, pp 103–107 | Cite as

Carotid body paraganglioma metastatic to bone: report of two cases

  • Akira Kawai
  • J. H. Healey
  • Scott C. Wilson
  • Andrew G. Huvos
  • Samuel D. J. Yeh
CASE REPORT

Abstract 

Two patients with carotid body paraganglioma developed bone metastases 3 and 6 years respectively after surgical excision of the primary tumors. Plain radiographs showed ill-defined metastatic lesions. Scintigram using radiolabeled metaiodobenzylguanidine, an analogue of noradrenaline that is taken up by neurosecretary granules, showed an abnormal accumulation in the corresponding metastatic lesion. Histologically, nests of epithelioid cells with clear cytoplasm and pyknotic nuclei and abundant collagen fibers were observed within destroyed trabeculae. Treatment including external radiation and surgery provided pain relief and early local disease control.

Key words Paraganglioma Metastasis bone Iodine-131 metaiodobenzylguanidine Radiation Surgery 

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Copyright information

© International Skeletal Society 1998

Authors and Affiliations

  • Akira Kawai
    • 1
  • J. H. Healey
    • 1
  • Scott C. Wilson
    • 1
  • Andrew G. Huvos
    • 2
  • Samuel D. J. Yeh
    • 3
  1. 1.Department of Surgery, Orthopaedic Surgery Service, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USAUS
  2. 2.Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, USAUS
  3. 3.Department of Radiology, Nuclear Medicine Service, Memorial Sloan-Kettering Cancer Center, New York, USAUS

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