Skeletal Radiology

, Volume 45, Issue 10, pp 1375–1384 | Cite as

Comparison of MRI and PET-CT in detecting the loco-regional recurrence of soft tissue sarcomas during surveillance

  • Sun-Young Park
  • Hye Won ChungEmail author
  • Sun Young Chae
  • Jong-Seok Lee
Scientific Article



To investigate the diagnostic performance of MRI and PET-CT for the detection of loco-regional recurrences after soft tissue sarcoma (STS) excision.

Materials and Methods

From Dec 2003 to Aug 2014, 394 patients with STSs, who were included in the electronic patient registry for initial or repeated surgery at our hospital, were retrospectively reviewed. We identified 152 patients who underwent regular postoperative follow-ups with both MRI and PET-CT, obtained within a 3 month period of each other. We analyzed differences in the performance of MRI and PET-CT for the diagnosis of loco-regional recurrences using McNemar’s test. The receiver-operating characteristic curves and calculations of the area under the curve were used.


Twenty patients were found to have a loco-regional recurrence after tumor excision. For MRI and PET-CT, the sensitivities were 90.0 and 95.0 %, and the specificities 97.7 and 95.5 %, respectively, with positive predictive values of 85.7 and 76.0 % and negative predictive values of 98.5 and 99.2 %, respectively. No significant difference was detected between the sensitivities of MRI and PET-CT (p = 0.125). The area under the receiver-operating characteristic curve for PET-CT (0.952) was not significantly greater than that for MRI (0.939; p = 0.6).


MRI of the area of interest is recommended for evaluation of tumor recurrence after surgical excision of STS. PET-CT was shown to be effective for detection of STS recurrence, and comparable to MRI. However, if PET-CT or MRI findings are inconclusive, the other modality may be helpful in differentiating tumor recurrence from post-therapeutic tissue change.


Soft tissue sarcoma Recurrence Paired comparison Magnetic resonance imaging Positron emission tomography 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© ISS 2016

Authors and Affiliations

  • Sun-Young Park
    • 1
    • 2
  • Hye Won Chung
    • 1
    Email author
  • Sun Young Chae
    • 3
  • Jong-Seok Lee
    • 4
  1. 1.Department of Radiology and Research Institute of RadiologyUniversity of Ulsan College of Medicine, Asan Medical CenterSeoulSouth Korea
  2. 2.Department of RadiologyHallym University Sacred Heart HospitalAnyang-siRepublic of Korea
  3. 3.Department of Nuclear MedicineUniversity of Ulsan College of Medicine, Asan Medical CenterSeoulSouth Korea
  4. 4.Department of Orthopedic SurgeryUniversity of Ulsan College of Medicine, Asan Medical CenterSeoulSouth Korea

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