Correlation of semiquantitative vs quantitative MRI meniscus measures in osteoarthritic knees: results from the Osteoarthritis Initiative
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Meniscus damage is associated with meniscus extrusion and with an increased risk of incident knee osteoarthritis [1, 2, 3]. Meniscus extrusion is associated with fast structural progression of knee osteoarthritis, potentially because of a peripheral shift of the meniscus and a greater exposure of tibial cartilage, causing less mechanical protection by the meniscus [4, 5].
In the above studies, meniscus extrusion was graded on MR images using semiquantitative (SQ) scoring systems, such as the Boston Leds Osteoarthritis Knee Score (BLOKS) or, the Magnetic resonance imaging Osteoarthritis Knee Score (MOAKS) [6, 7]. Recently, we proposed quantitative technology for measuring meniscus size and position, specifically meniscus extrusion (qEx) . We showed that quantitative measures of meniscus size and position display satisfactory inter- and intra-observer reproducibility, discriminate between knees with different radiographic disease stages between bilateral knees discordant...
KeywordsTibial Plateau Joint Space Narrowing Medial Meniscus Medial Tibial Plateau Tibial Cartilage
The study and image acquisition was funded by the Osteoarthritis Initiative, a public–private partnership comprising five contracts: N01-AR-2-2258; N01-AR-2-2259; N01-AR-2-2260; N01-AR-2-2261; N01-AR-2-2262. Image analysis was funded by the Paracelsus Medical University Research Fund (PMU FFF R-12702/036/BLO).
Conflict of interest
K. Bloecker: none; W. Wirth: part-time employee and co-owner of Chondrometrics GmbH, Ainring, Germany, a company providing an image analysis service to other researchers and the pharmaceutical industry; D.J. Hunter: none; A. Guermazi is President and co-owner of the Boston Core Imaging Lab (BICL), a company providing MRI reading services to academic researchers and to industry, and he provides consulting services to Genzyme; K. Kwoh has provided consulting services for Novartis and has received research support from Astra-Zeneca; H. Resch: none; F. Eckstein: part-time employee and co-owner of Chondrometrics GmbH, Ainring, Germany, a company providing an image analysis service to other researchers and the pharmaceutical industry, and he provides consulting services for Merck Serono and Abbvie.
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