Skeletal Radiology

, Volume 42, Issue 6, pp 827–835 | Cite as

Human hand radiography using X-ray differential phase contrast combined with dark-field imaging

  • Thomas ThüringEmail author
  • Roman Guggenberger
  • Hatem Alkadhi
  • Jürg Hodler
  • Magdalena Vich
  • Zhentian Wang
  • Christian David
  • Marco Stampanoni
Technical Report


Established X-ray-based imaging procedures such as conventional radiography and computed tomography (CT) rely on the interaction of photons when passing through tissue, including the Compton scattering and the photoelectric effect, which is influenced by the X-ray energy and the type of matter. The resulting mean attenuation of X-rays can be measured and depicted on images with different gray levels.

X-ray phase contrast imaging (PCI) represents a relatively new imaging technique relying upon the refraction of X-rays. As such, PCI relies on a fundamentally different physical contrast mechanism compared with conventional, absorption-based X-ray imaging. In the energy range of diagnostic imaging (10–120 keV), refraction is the dominant effect over absorption, but more difficult to acquire. Previous studies have demonstrated that PCI can provide considerably higher contrast in soft tissue, giving rise to its application in fields where conventional radiography and CT are...


Phase Contrast Joint Space Subchondral Bone Conventional Radiography Absorption Image 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The authors thank Gordan Mikuljan from Paul Scherrer Institute for the design and manufacturing of various mechanical components. They also thank Prof. Verdun from the Institute of Radiation Physics at the University Hospital center Lausanne for his competent help in dose calculations. Part of this work has been supported by the ERC Grant ERC-2012-StG 310005-PhaseX.

Supplementary material

256_2013_1606_MOESM1_ESM.docx (45 kb)
ESM 1 (DOCX 45 kb)


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Copyright information

© ISS 2013

Authors and Affiliations

  • Thomas Thüring
    • 1
    • 2
    Email author
  • Roman Guggenberger
    • 3
  • Hatem Alkadhi
    • 3
  • Jürg Hodler
    • 3
  • Magdalena Vich
    • 4
  • Zhentian Wang
    • 1
  • Christian David
    • 1
  • Marco Stampanoni
    • 1
    • 2
  1. 1.Paul Scherrer InstitutVilligenSwitzerland
  2. 2.Institute for Biomedical Engineering, Swiss Federal Institute of TechnologyZurichSwitzerland
  3. 3.Institute of Diagnostic and Interventional RadiologyUniversity Hospital ZurichZurichSwitzerland
  4. 4.Institute of AnatomyUniversity ZurichZurichSwitzerland

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