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Skeletal Radiology

, Volume 42, Issue 7, pp 993–1000 | Cite as

Technical innovation in dynamic contrast-enhanced magnetic resonance imaging of musculoskeletal tumors: an MR angiographic sequence using a sparse k-space sampling strategy

  • Laura M. FayadEmail author
  • Charles Mugera
  • Theodoros Soldatos
  • Aaron Flammang
  • Filippo del Grande
Technical Report

Abstract

Objective

We demonstrate the clinical use of an MR angiography sequence performed with sparse k-space sampling (MRA), as a method for dynamic contrast-enhanced (DCE)-MRI, and apply it to the assessment of sarcomas for treatment response.

Materials and methods

Three subjects with sarcomas (2 with osteosarcoma, 1 with high-grade soft tissue sarcomas) underwent MRI after neoadjuvant therapy/prior to surgery, with conventional MRI (T1-weighted, fluid-sensitive, static post-contrast T1-weighted sequences) and DCE-MRI (MRA, time resolution = 7–10 s, TR/TE 2.4/0.9 ms, FOV 40 cm2). Images were reviewed by two observers in consensus who recorded image quality (1 = diagnostic, no significant artifacts, 2 = diagnostic, <25 % artifacts, 3 = nondiagnostic) and contrast enhancement characteristics by static MRI (presence/absence of contrast enhancement, percentage of enhancement) and DCE-MRI (presence/absence of arterial enhancement with time–intensity curves). Results were compared with histological response (defined as <5 % viable tumor [soft tissue sarcoma] or <10 % [bone sarcoma] following resection).

Results

Diagnostic quality for all conventional and DCE-MRI sequences was rated as 1. In 2 of the 3 sarcomas, there was good histological response (≤5 % viable tumor); in 1 there was poor response (50 % viable tumor). By static post-contrast T1-weighted sequences, there was enhancement in all sarcomas, regardless of response (up to >75 % with good response, >75 % with poor response). DCE-MRI findings were concordant with histological response (arterial enhancement with poor response, no arterial enhancement with good response).

Conclusion

Unlike conventional DCE-MRI sequences, an MRA sequence with sparse k-space sampling is easily integrated into a routine musculoskeletal tumor MRI protocol, with high diagnostic quality. In this preliminary work, tumor enhancement characteristics by DCE-MRI were used to assess treatment response.

Keywords

Dynamic contrast-enhanced MRI MR angiography Tumor Sarcoma Musculoskeletal 

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Copyright information

© ISS 2013

Authors and Affiliations

  • Laura M. Fayad
    • 1
    Email author
  • Charles Mugera
    • 1
  • Theodoros Soldatos
    • 2
    • 3
  • Aaron Flammang
    • 4
  • Filippo del Grande
    • 1
  1. 1.Russell H. Morgan Department of Radiology and Radiological SciencesJohns Hopkins Medical InstitutionsBaltimoreUSA
  2. 2.Musculoskeletal Imaging SectionJohns Hopkins Medical InstitutionsBaltimoreUSA
  3. 3.Research Unit of Radiology and Medical Imaging, Evgenidion HospitalUniversity of AthensAthensGreece
  4. 4.Center for Applied Medical ImagingSiemens Corporate ResearchBaltimoreUSA

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