Skeletal Radiology

, Volume 42, Issue 3, pp 363–370 | Cite as

Three-dimensional topographical variation of femoral cartilage T2 in healthy volunteer knees

  • Toshiyuki Shiomi
  • Takashi NishiiEmail author
  • Ken Nakata
  • Satoru Tamura
  • Hisashi Tanaka
  • Youichi Yamazaki
  • Kenya Murase
  • Hideki Yoshikawa
  • Nobuhiko Sugano
Scientific Article



Quantitative knee cartilage T2 assessment on limited two-dimensional midsagittal or midcoronal planes may be insufficient to assess variations in normal cartilage composition. The purpose of this work was to reveal characteristic 3D distribution of T2 values in femoral cartilage in healthy volunteer knees.

Materials and methods

Sixteen volunteers were enrolled in this study. One knee joint in each volunteer was imaged using a 3D fast image employing steady-state acquisition cycled phases (FIESTA-C) sequence for modeling distal femoral morphology, as well as a sagittal T2 mapping of cartilage. 3D distribution of cartilage T2 values was generated for the femoral condyles. At each medial and lateral condyle, four regions of interest (ROI) were manually defined based on the cartilage covered by the 3D surface model of the medial and lateral menisci.


The 3D maps showed a relatively inhomogeneous distribution of cartilage T2 on the medial and lateral condyles. Cartilage T2 values in the internal half of the weight-bearing zone were significantly higher than those in all other zones on both lateral and medial condyles.


Analysis of 3D distribution of femoral cartilage T2 may be valuable in determining the site-specific normal range of cartilage T2 in the healthy knee joint.


MRI Cartilage T2 Three dimension Topographical variation Knee joint 



This work was supported in part by Health and Labour Science Research Grants of Comprehensive Research on Aging and Health, and Grant-in-Aid for Scientific Research of the Ministry of Education, Science and Culture (22390290) in Japan. The authors declare that they have no conflicts of interest.


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Copyright information

© ISS 2012

Authors and Affiliations

  • Toshiyuki Shiomi
    • 1
  • Takashi Nishii
    • 1
    • 2
    Email author
  • Ken Nakata
    • 1
  • Satoru Tamura
    • 2
  • Hisashi Tanaka
    • 3
  • Youichi Yamazaki
    • 4
  • Kenya Murase
    • 4
  • Hideki Yoshikawa
    • 1
  • Nobuhiko Sugano
    • 1
    • 2
  1. 1.Department of Orthopaedic SurgeryOsaka University Medical SchoolSuitaJapan
  2. 2.Department of Orthopaedic Medical EngineeringOsaka University Medical SchoolSuitaJapan
  3. 3.Department of RadiologyOsaka University Medical SchoolSuitaJapan
  4. 4.Department of Medical Physics and EngineeringOsaka University Medical SchoolSuitaJapan

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