Skeletal Radiology

, Volume 41, Issue 3, pp 357–360 | Cite as

Magnetic resonance imaging appearance of scurvy with gelatinous bone marrow transformation

  • Christopher M. Brennan
  • Kristen A. Atkins
  • Colleen H. Druzgal
  • Cree M. Gaskin
Case Report

Abstract

Scurvy is a lethal but treatable disease that is rare in industrialized countries. Caused by vitamin C deficiency, it is most prevalent in persons of low socioeconomic status and smokers. Low levels of circulating vitamin C result in poor collagen fiber formation that, in turn, leads to demineralized bones, microfractures, and poor healing. Here we report a case of scurvy in a 5-year-old boy with normal radiographs in whom initial concern for leukemia based upon magnetic resonance imaging and clinical presentation led to a bone marrow biopsy revealing gelatinous transformation.

Keywords

Scurvy Vitamin C Malnutrition Magnetic resonance imaging Serous atrophy Gelatinous transformation 

References

  1. 1.
    Brailsford JF. Some radiographic manifestations of early scurvy. Arch Dis Child. 1953;28(138):81–6.PubMedCrossRefGoogle Scholar
  2. 2.
    McCann P. The incidence and value of radiological signs in scurvy. Br J Radiol. 1962;35:683–6.PubMedCrossRefGoogle Scholar
  3. 3.
    Laor T, Jaramillo D. MR imaging insights into skeletal maturation: what is normal? Radiology. 2009;250(1):28–38.PubMedCrossRefGoogle Scholar
  4. 4.
    Hodges RE, Hood J, Canham JE, Sauberlich HE, Baker EM. Clinical manifestations of ascorbic acid deficiency in man. Am J Clin Nutr. 1971;24(4):432–43.PubMedGoogle Scholar
  5. 5.
    Pemberton J. Medical experiments carried out in Sheffield on conscientious objectors to military service during the 1939–45 war. Int J Epidemiol. 2006;35(3):556–8.PubMedCrossRefGoogle Scholar
  6. 6.
    Schleicher RL, Carroll MD, Ford ES, Lacher DA. Serum vitamin C and the prevalence of vitamin C deficiency in the United States: 2003–2004 National Health and Nutrition Examination Survey (NHANES). Am J Clin Nutr. 2009;90(5):1252–63.PubMedCrossRefGoogle Scholar
  7. 7.
    Fain O. Musculoskeletal manifestations of scurvy. Joint Bone Spine. 2005;72(2):124–8.PubMedCrossRefGoogle Scholar
  8. 8.
    Kato K. A critique of the roentgen signs of infantile scurvy with report of thirteen cases. Radiology. 1932;18:15.Google Scholar
  9. 9.
    Choi SW, Park SW, Kwon YS, et al. MR imaging in a child with scurvy: a case report. Korean J Radiol. 2007;8(5):443–7.PubMedCrossRefGoogle Scholar
  10. 10.
    Karthiga S, Dubey S, Garber S, Watts R. Scurvy: MRI appearances. Rheumatology (Oxford). 2008;47(7):1109.CrossRefGoogle Scholar
  11. 11.
    Bohm J. Gelatinous transformation of the bone marrow: the spectrum of underlying diseases. Am J Surg Pathol. 2000;24(1):56–65.PubMedCrossRefGoogle Scholar
  12. 12.
    Kaplan P, Helms C, Dussault R, Anderson M, Major N. Musculoskeletal MRI. 2nd ed. Philadelphia: Saunders; 2001.Google Scholar

Copyright information

© ISS 2012

Authors and Affiliations

  • Christopher M. Brennan
    • 1
  • Kristen A. Atkins
    • 3
  • Colleen H. Druzgal
    • 4
  • Cree M. Gaskin
    • 1
    • 2
  1. 1.Department of Radiology and Medical ImagingUniversity of Virginia Health SystemCharlottesvilleUSA
  2. 2.Department of Orthopaedic SurgeryUniversity of Virginia Health SystemCharlottesvilleUSA
  3. 3.Department of PathologyUniversity of Virginia Health SystemCharlottesvilleUSA
  4. 4.Department of PediatricsUniversity of Virginia Health SystemCharlottesvilleUSA

Personalised recommendations