Skeletal Radiology

, Volume 41, Issue 6, pp 719–723 | Cite as

Leiomyosarcoma in the humerus with leukocytosis and elevation of serum G-CSF

  • Takeaki Ishii
  • Akio Sakamoto
  • Shuichi Matsuda
  • Yoshihiro Matsumoto
  • Katsumi Harimaya
  • Yusuke Takahashi
  • Yoshinao Oda
  • Yukihide Iwamoto
Case Report

Abstract

Leukocytosis associated with secretion of granulocyte colony-stimulating factor (G-CSF) has been reported in various tumors, primarily poorly differentiated epithelial tumors, but is extremely rare in bone tumors. An 84-year-old woman experienced swelling and pain in the shoulder for 1 month. Leukocytosis and elevated serum G-CSF were observed, but resolved following tumor resection. A diagnosis of leiomyosarcoma of the bone with expression of G-CSF was confirmed immunohistochemically. Histological diagnosis of leiomyosarcoma showed it to be differentiated, which is unusual for G-CSF–secreting tumors.

Keywords

Leiomyosarcoma Bone Granulocyte colony-stimulating factor Leukocytosis 

References

  1. 1.
    Ayabe E, Kaira K, Takahashi T, Murakami H, Tsuya A, Nakamura Y, et al. Thymic squamous cell carcinoma producing granulocyte colony-stimulating factor associated with a high serum level of interleukin 6. Int J Clin Oncol. 2009;14(6):534–6.PubMedCrossRefGoogle Scholar
  2. 2.
    Joshita S, Nakazawa K, Koike S, Kamijo A, Matsubayashi K, Miyabayashi H, et al. A case of granulocyte-colony stimulating factor-producing hepatocellular carcinoma confirmed by immunohistochemistry. J Korean Med Sci. 2010;25(3):476–80.PubMedCrossRefGoogle Scholar
  3. 3.
    Kawaguchi M, Asada Y, Terada T, Takehara A, Munemoto Y, Fujisawa K, et al. Aggressive recurrence of gastric cancer as a granulocyte-colony-stimulating factor-producing tumor. Int J Clin Oncol. 2010;15(2):191–5.PubMedCrossRefGoogle Scholar
  4. 4.
    Mabuchi S, Matsumoto Y, Morii E, Morishige K, Kimura T. The first 2 cases of granulocyte colony-stimulating factor producing adenocarcinoma of the uterine cervix. Int J Gynecol Pathol. 2010;29(5):483–7.PubMedCrossRefGoogle Scholar
  5. 5.
    Sawazaki H, Taki Y, Takeuchi H. Granulocyte colony-stimulating factor (G-CSF) producing bladder cancer subsequently developed from recurrent non-muscle invasive bladder cancer. Int J Urol. 2010;17(8):741–2. PubMedCrossRefGoogle Scholar
  6. 6.
    Takagi Y, Nakamura H, Miwa K, Adachi Y, Fujioka S, Haruki T, et al. A case of G-CSF-producing invasive apical cancer resected following preoperative adjuvant therapy. Thorac Cardiovasc Surg. 2010;58(5):304–6. PubMedCrossRefGoogle Scholar
  7. 7.
    Yamano T, Morii E, Ikeda J, Aozasa K. Granulocyte colony-stimulating factor production and rapid progression of gastric cancer after histological change in the tumor. Jpn J Clin Oncol. 2007;37(10):793–6. PubMedCrossRefGoogle Scholar
  8. 8.
    Sakamoto A, Yamamoto H, Tanaka K, Matsuda S, Harimaya K, Oda Y, et al. Dedifferentiated chondrosarcoma with leukocytosis and elevation of serum G-CSF. A case report. World J Surg Oncol. 2006;4:37.PubMedCrossRefGoogle Scholar
  9. 9.
    Marui T, Yamamoto T, Akisue T, Hitora T, Yoshiya S, Kurosaka M. Granulocyte colony-stimulating factor-producing undifferentiated sarcoma occurring in previously fractured femur. Arch Pathol Lab Med. 2003;127(4):e186–9. PubMedGoogle Scholar
  10. 10.
    Wirbel RJ, Verelst S, Hanselmann R, Remberger K, Kubale R, Mutschler WE. Primary leiomyosarcoma of bone: clinicopathologic, immunohistochemical, and molecular biologic aspects. Ann Surg Oncol. 1998;5(7):635–41.PubMedCrossRefGoogle Scholar
  11. 11.
    Kitajima K, Murakami K, Kaji Y, Sugimura K. Spectrum of FDG PET/CT findings of uterine tumors. AJR Am J Roentgenol. 2010;195(3):737–43.PubMedCrossRefGoogle Scholar
  12. 12.
    Morales-Arias J, Meyers PA, Bolontrade MF, Rodriguez N, Zhou Z, Reddy K, et al. Expression of granulocyte-colony-stimulating factor and its receptor in human Ewing sarcoma cells and patient tumor specimens: potential consequences of granulocyte-colony-stimulating factor administration. Cancer. 2007;110(7):1568–77.PubMedCrossRefGoogle Scholar
  13. 13.
    Thacker JD, Dedhar S, Hogge DE. The effect of GM-CSF and G-CSF on the growth of human osteosarcoma cells in vitro and in vivo. Int J Cancer. 1994;56(2):236–43. PubMedCrossRefGoogle Scholar
  14. 14.
    Munstedt K, Hackethal A, Eskef K, Hrgovic I, Franke FE. Prognostic relevance of granulocyte colony-stimulating factor in ovarian carcinomas. Arch Gynecol Obstet. 2010;282(3):301–5.PubMedCrossRefGoogle Scholar
  15. 15.
    Yabuta M, Takeuchi K, Kitazawa S, Morita H. Leukocytosis as an initial sign of aggressive growth of granulocyte colony-stimulating factor-producing cervical cancer. Int J Gynaecol Obstet. 2010;111(2):181–2. PubMedCrossRefGoogle Scholar
  16. 16.
    Sakamoto A, Matono H, Yoshida T, Tanaka K, Matsuda S, Oda Y, et al. Dedifferentiated liposarcoma with leukocytosis. A case report of G-CSF-producing soft-tissue tumors, possible association with undifferentiated liposarcoma lineage. World J Surg Oncol. 2007;5:131.PubMedCrossRefGoogle Scholar

Copyright information

© ISS 2011

Authors and Affiliations

  • Takeaki Ishii
    • 1
  • Akio Sakamoto
    • 1
  • Shuichi Matsuda
    • 1
  • Yoshihiro Matsumoto
    • 1
  • Katsumi Harimaya
    • 1
  • Yusuke Takahashi
    • 2
  • Yoshinao Oda
    • 2
  • Yukihide Iwamoto
    • 1
  1. 1.Department of Orthopaedic Surgery, Graduate School of Medical SciencesKyushu UniversityFukuokaJapan
  2. 2.Department of Anatomic Pathology, Graduate School of Medical SciencesKyushu UniversityFukuokaJapan

Personalised recommendations