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Skeletal Radiology

, Volume 41, Issue 8, pp 971–980 | Cite as

Diffusion tensor imaging of the median nerve: intra-, inter-reader agreement, and agreement between two software packages

  • Roman Guggenberger
  • Daniel Nanz
  • Gilbert Puippe
  • Kaspar Rufibach
  • Lawrence M. White
  • Marshall S. Sussman
  • Gustav AndreisekEmail author
Scientific Article

Abstract

Objective

To assess intra-, inter-reader agreement, and the agreement between two software packages for magnetic resonance diffusion tensor imaging (DTI) measurements of the median nerve.

Materials and methods

Fifteen healthy volunteers (seven men, eight women; mean age, 31.2 years) underwent DTI of both wrists at 1.5 T. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) of the median nerve were measured by three readers using two commonly used software packages. Measurements were repeated by two readers after 6 weeks. Intraclass correlation coefficients (ICC) and Bland-Altman analysis were used for statistical analysis.

Results

ICCs for intra-reader agreement ranged from 0.87 to 0.99, for inter-reader agreement from 0.62 to 0.83, and between the two software packages from 0.63 to 0.82. Bland-Altman analysis showed no differences for intra- and inter-reader agreement and agreement between software packages.

Conclusion

The intra-, inter-reader, and agreement between software packages for DTI measurements of the median nerve were moderate to substantial suggesting that user- and software-dependent factors contribute little to variance in DTI measurements.

Keywords

Magnetic resonance imaging Diffusion tensor imaging Median nerve Neuropathy Software 

Abbreviations

ADC

Apparent diffusion coefficient

CSA

Cross-sectional area

DTI

Diffusion tensor imaging

FA

Fractional anisotropy

FoV

Field of view

FSE

Fast spin-echo

HA

Hamate bone

ICC

Intra-class correlation coefficient

NEX

Number of excitations

MR

Magnetic resonance

PI

Pisiform bone

RC

Radio-carpal joint

ROI

Region of interest

ssSE EPI

Single-shot spin-echo-based echo planar imaging

TE

Echo time

TR

Relaxation time

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Copyright information

© ISS 2011

Authors and Affiliations

  • Roman Guggenberger
    • 1
  • Daniel Nanz
    • 1
  • Gilbert Puippe
    • 1
  • Kaspar Rufibach
    • 2
  • Lawrence M. White
    • 3
  • Marshall S. Sussman
    • 4
  • Gustav Andreisek
    • 1
    Email author
  1. 1.Musculoskeletal Imaging Research Group, Department of RadiologyUniversity Hospital ZurichZurichSwitzerland
  2. 2.Division of Biostatistics, Institute for Social and Preventive MedicineUniversity of ZurichZurichSwitzerland
  3. 3.Department of Medical Imaging, Mount Sinai Hospital and the University Health NetworkUniversity of TorontoTorontoCanada
  4. 4.Department of Medical ImagingUniversity Health Network, University of TorontoTorontoCanada

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