Skeletal Radiology

, Volume 41, Issue 3, pp 249–256 | Cite as

Diagnostic accuracy of 18 F-FDG-PET and PET/CT in patients with Ewing sarcoma family tumours: a systematic review and a meta-analysis

  • Giorgio TregliaEmail author
  • Marco Salsano
  • Antonella Stefanelli
  • Maria Vittoria Mattoli
  • Alessandro Giordano
  • Lorenzo Bonomo
Review Article



To systematically review and meta-analyse literature data on the diagnostic performance of fluorine-18-fluorodeoxyglucose (FDG) positron emission tomography (PET) and positron emission tomography/computed tomography (PET/CT) in patients with Ewing sarcoma family tumours (ESFT).

Materials and methods

PubMed/MEDLINE, Embase and Scopus databases were searched for articles that evaluated FDG-PET and PET/CT in patients with ESFT from inception to 31 May 2011. Studies that fulfilled the three following criteria were included in the systematic review: FDG-PET or PET/CT performed in patients with ESFT; articles about the diagnostic accuracy of FDG-PET and PET/CT; sample size of at least 10 patients with ESFT were included. Studies in which there were sufficient data to reassess sensitivity and specificity of FDG-PET or PET/CT in ESFT were included in the meta-analysis, excluding duplicate publications. Finally, pooled sensitivity, pooled specificity and area under the receiver operating characteristic (ROC) curve of FDG-PET or PET/CT in ESFT were calculated.


We found 13 studies comprising a total of 342 patients with ESFT. The main findings of the studies included are presented. The meta-analysis of five selected studies provided these results about FDG-PET and PET/CT in ESFT: pooled sensitivity: 96% (95% confidence interval [CI] 91–99%); pooled specificity: 92% (95% CI 87–96%); area under the ROC curve: 0.97.


With regard to the staging and restaging of patients with ESFT, the sensitivity, specificity and accuracy of FDG-PET and PET/CT are high; the combination of FDG-PET or PET/CT with conventional imaging is a valuable tool for the staging and restaging of ESFT and has a relevant impact on the treatment strategy plan.


Positron emission tomography PET/CT Ewing sarcoma Ewing sarcoma family tumours 


Conflicts of interest

The authors declare that they have no conflict of interest.


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Copyright information

© ISS 2011

Authors and Affiliations

  • Giorgio Treglia
    • 1
    • 3
    Email author
  • Marco Salsano
    • 1
  • Antonella Stefanelli
    • 1
  • Maria Vittoria Mattoli
    • 1
  • Alessandro Giordano
    • 1
  • Lorenzo Bonomo
    • 2
  1. 1.Department of Bioimaging and Radiological SciencesInstitute of Nuclear Medicine, Catholic University of the Sacred HeartRomeItaly
  2. 2.Department of Bioimaging and Radiological SciencesInstitute of Radiology, Catholic University of the Sacred HeartRomeItaly
  3. 3.Department of Bioimaging and Radiological SciencesInstitute of Nuclear Medicine, Positron Emission Tomography Centre, Catholic University of the Sacred HeartRomeItaly

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