Skeletal Radiology

, Volume 41, Issue 4, pp 409–414

Osteosclerotic lesions in patients treated with gefitinib for lung adenocarcinomas: a sign of favorable therapeutic response

  • Yoshiko Yamashita
  • Takatoshi Aoki
  • Takeshi Hanagiri
  • Chiharu Yoshii
  • Hiroshi Mukae
  • Hidetaka Uramoto
  • Yukunori Korogi
Scientific Article



To assess the frequency of osteosclerotic changes on CT that appeared after treatment with gefitinib in patients with lung adenocarcinoma and the relationship between the osteosclerotic changes and the response to the therapy.

Materials and methods

Our study included 41 patients with lung adenocarcinoma who underwent chest CT both before (CTpre) and after (CTpost) starting treatment with gefitinib. The presence or absence of bone metastases was assessed on the CTpre, and the interval bony change after the therapy was classified as lytic, sclerotic, or no changes on the CTpost. The relationship between treatment results of primary lung cancer and interval bony changes was evaluated.


Osteosclerotic lesions were identified in 11 patients (27%) on CTpost; in 6 of 11 patients osteosclerotic lesions newly appeared where the CTpre showed no bone metastasis before the gefitinib therapy. There were significant differences in the therapeutic response of the primary cancers (P < 0.001) and in the survival rate (P < 0.01) in patients with osteosclerotic changes versus those without osteosclerotic changes.


Osteosclerotic changes on CT, observed after gefitinib treatment in patients with lung adenocarcinomas, may be an indicator of a good therapeutic response.


Bone Lung cancer CT Gefitinib Metastasis 


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Copyright information

© ISS 2011

Authors and Affiliations

  • Yoshiko Yamashita
    • 1
  • Takatoshi Aoki
    • 1
  • Takeshi Hanagiri
    • 2
  • Chiharu Yoshii
    • 3
  • Hiroshi Mukae
    • 3
  • Hidetaka Uramoto
    • 2
  • Yukunori Korogi
    • 1
  1. 1.Department of RadiologyUniversity of Occupational and Environmental Health, School of MedicineKitakyushuJapan
  2. 2.Second Department of SurgeryUniversity of Occupational and Environmental Health, School of MedicineKitakyushuJapan
  3. 3.Department of Respiratory DiseaseUniversity of Occupational and Environmental Health, School of MedicineKitakyushuJapan

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