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Skeletal Radiology

, Volume 41, Issue 2, pp 163–167 | Cite as

Correlation between T2 relaxation time and intervertebral disk degeneration

  • Hiroyuki Takashima
  • Tsuneo TakebayashiEmail author
  • Mitsunori Yoshimoto
  • Yoshinori Terashima
  • Hajime Tsuda
  • Kazunori Ida
  • Toshihiko Yamashita
Scientific Article

Abstract

Objective

Magnetic resonance T2 mapping allows for the quantification of water and proteoglycan content within tissues and can be used to detect early cartilage abnormalities as well as to track the response to therapy. The goal of the present study was to use T2 mapping to quantify intervertebral disk water content according to the Pfirrmann classification.

Materials and methods

This study involved 60 subjects who underwent lumbar magnetic resonance imaging (a total of 300 lumbar disks). The degree of disk degeneration was assessed in the midsagittal section on T2-weighted images according to the Pfirrmann classification (grades I to V). Receiver operating characteristic (ROC) analysis was performed among grades to determine the cut-off values.

Results

In the nucleus pulposus, T2 values tended to decrease with increasing grade, and there was a significant difference in T2 values between each grade from grades I to IV. However, there was no significant difference in T2 values in the anterior or posterior annulus fibrosus. T2 values according to disk degeneration level classification were as follows: grade I (>116.8 ms), grade II (92.7–116.7 ms), grade III (72.1–92.6 ms), grade IV (<72.0 ms).

Conclusion

T2 values decreased with increasing Pfirrmann classification grade in the nucleus pulposus, likely reflecting a decrease in proteoglycan and water content. Thus, T2 value-based measurements of intervertebral disk water content may be useful for future clinical research on degenerative disk diseases.

Keywords

Lumbar disk degeneration T2 relaxation time Classification 

Notes

Acknowledgement

Conflict of interest

The authors declare that there is no conflict of interest.

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Copyright information

© ISS 2011

Authors and Affiliations

  • Hiroyuki Takashima
    • 1
  • Tsuneo Takebayashi
    • 1
    Email author
  • Mitsunori Yoshimoto
    • 1
  • Yoshinori Terashima
    • 1
  • Hajime Tsuda
    • 1
  • Kazunori Ida
    • 1
  • Toshihiko Yamashita
    • 1
  1. 1.Department of Orthopedic Surgery, School of MedicineSapporo Medical UniversitySapporoJapan

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