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Skeletal Radiology

, Volume 40, Issue 11, pp 1391–1397 | Cite as

Gorham–Stout disease: the experience of the Rizzoli Institute and review of the literature

  • Pietro RuggieriEmail author
  • Maurizio Montalti
  • Andrea Angelini
  • Marco Alberghini
  • Mario Mercuri
Review Article

Abstract

Gorham–Stout disease (also known as “disappearing bone disease”) was first described by Jackson in 1838, but was properly defined by Gorham and Stout in a series of 24 patients in 1954–1955. It is a rare disease of unknown etiology (about 200 cases reported in the literature) characterized by spontaneous progressive resorption of bone without malignant proliferation of vascular structures. The diagnosis is one of exclusion and it is based on combined histological, radiological, and clinical features. Benign vascular proliferation with fatty bone marrow and thinning of bony trabeculae is a typical histological feature. Standard radiographs of disappearing bone disease show progressive bony resorption with adjacent soft tissue involvement. Most cases of Gorham–Stout disease resolve spontaneously, but prognosis remains unpredictable. This study reports 13 cases of Gorham–Stout disease treated in our institution from 1968 to 2008. The aim of the work was to review our series and the literature on this rare disease, as well as to evaluate whether or not an optimal treatment can be identified and recommended.

Keywords

Gorham–Stout disease Massive osteolysis Vanishing bone disease Hemangiomatosis MRI 

Notes

Conflict of interest

The authors declare that there is no conflict of interest.

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Copyright information

© ISS 2010

Authors and Affiliations

  • Pietro Ruggieri
    • 1
    Email author
  • Maurizio Montalti
    • 1
  • Andrea Angelini
    • 1
  • Marco Alberghini
    • 2
  • Mario Mercuri
    • 1
  1. 1.Department of OrthopedicsUniversity of Bologna, Istituto Ortopedico RizzoliBolognaItalia
  2. 2.Anatomy and Pathological Histology UnitIstituto Ortopedico RizzoliBolognaItalia

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