Skeletal Radiology

, Volume 38, Issue 3, pp 287–292 | Cite as

Soft-tissue amyloidoma of the extremities: a case report and review of literature

  • Aditya V. Maheshwari
  • Carlos A. Muro-Cacho
  • Mark J. Kransdorf
  • H. Thomas Temple
Case Report

Abstract

Amyloidosis is a heterogeneous group of disorders characterized by extracellular deposition of unique protein fibrils. Amyloidosis may be hereditary or acquired, and the deposits may be focal, localized, or systemic in distribution. The least common presentation of an amyloid deposition is as a discrete mass called amyloidoma or amyloid tumor. Although described at various body sites, soft-tissue amyloidoma in an extremity is exceedingly rare. We report such a case of a large amyloidoma in the thigh, which simulated a soft-tissue sarcoma. In spite of attaining a very large size over a course of more than 20 years, the clinical course and the histology of this lesion were benign. Awareness of this entity will allow this rare diagnosis to be considered, prevent confusion with malignant disease, and allow appropriate management and patient reassurance. A review of literature on soft-tissue amyloidomas of extremities is also being presented.

Keywords

Amyloidoma Soft-tissue amyloidoma Extremity amyloidoma Amyloidosis 

Notes

Acknowledgment

The authors thank Zoraida Moore for her assistance in preparing this manuscript.

Conflict of interest statement

None.

Financial disclosure

None.

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Copyright information

© ISS 2008

Authors and Affiliations

  • Aditya V. Maheshwari
    • 1
  • Carlos A. Muro-Cacho
    • 2
  • Mark J. Kransdorf
    • 3
  • H. Thomas Temple
    • 1
  1. 1.Division of Musculoskeletal Oncology, Department of OrthopedicsUniversity of Miami Miller School of MedicineMiamiUSA
  2. 2.Department of PathologyUniversity of Miami Miller School of MedicineMiamiUSA
  3. 3.Department of RadiologyMayo ClinicJacksonvilleUSA

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