Skeletal Radiology

, Volume 38, Issue 3, pp 287–292 | Cite as

Soft-tissue amyloidoma of the extremities: a case report and review of literature

  • Aditya V. MaheshwariEmail author
  • Carlos A. Muro-Cacho
  • Mark J. Kransdorf
  • H. Thomas Temple
Case Report


Amyloidosis is a heterogeneous group of disorders characterized by extracellular deposition of unique protein fibrils. Amyloidosis may be hereditary or acquired, and the deposits may be focal, localized, or systemic in distribution. The least common presentation of an amyloid deposition is as a discrete mass called amyloidoma or amyloid tumor. Although described at various body sites, soft-tissue amyloidoma in an extremity is exceedingly rare. We report such a case of a large amyloidoma in the thigh, which simulated a soft-tissue sarcoma. In spite of attaining a very large size over a course of more than 20 years, the clinical course and the histology of this lesion were benign. Awareness of this entity will allow this rare diagnosis to be considered, prevent confusion with malignant disease, and allow appropriate management and patient reassurance. A review of literature on soft-tissue amyloidomas of extremities is also being presented.


Amyloidoma Soft-tissue amyloidoma Extremity amyloidoma Amyloidosis 



The authors thank Zoraida Moore for her assistance in preparing this manuscript.

Conflict of interest statement


Financial disclosure



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© ISS 2008

Authors and Affiliations

  • Aditya V. Maheshwari
    • 1
    Email author
  • Carlos A. Muro-Cacho
    • 2
  • Mark J. Kransdorf
    • 3
  • H. Thomas Temple
    • 1
  1. 1.Division of Musculoskeletal Oncology, Department of OrthopedicsUniversity of Miami Miller School of MedicineMiamiUSA
  2. 2.Department of PathologyUniversity of Miami Miller School of MedicineMiamiUSA
  3. 3.Department of RadiologyMayo ClinicJacksonvilleUSA

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