Skeletal Radiology

, Volume 37, Issue 5, pp 465–467

Hyperplastic callus formation in osteogenesis imperfecta type V: follow-up of three generations over ten years

  • Moira S. Cheung
  • E. Michel Azouz
  • Francis H. Glorieux
  • Frank Rauch
Case Report


Hyperplastic callus (HPC) formation is a prominent feature of osteogenesis imperfecta (OI) type V; however, little is known about its long-term outcome. In this case report we describe the occurrence, appearance and course of a femoral HPC in a patient with OI type V during 10 years of follow-up. Radiographs of HPC in this child were compared and contrasted with HPC formation in the femur of his father and paternal grandfather, who also were affected with OI type V. This case report makes it clear that HPC can lead to significant morbidity, not only in the acute phase but also long term as a result of residual alteration in bone architecture.


Fractures Genetic disorder Hyperplastic callus Osteogenesis imperfecta Radiographs 


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Copyright information

© ISS 2008

Authors and Affiliations

  • Moira S. Cheung
    • 1
  • E. Michel Azouz
    • 1
  • Francis H. Glorieux
    • 1
  • Frank Rauch
    • 1
    • 2
  1. 1.Genetics UnitShriners Hospital for Children and McGill UniversityMontrealCanada
  2. 2.Genetics UnitShriners Hospital for ChildrenMontrealCanada

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