Skeletal Radiology

, Volume 36, Issue 2, pp 95–104 | Cite as

Langerhans cell histiocytosis

  • Kevin Bradford Hoover
  • Daniel I. Rosenthal
  • Henry Mankin
Review Article

Abstract

Langerhans cell histiocytosis (LCH) is a complex disease entity comprised of three distinct clinical syndromes that demonstrate indistinguishable histology. These syndromes are: eosinophilic granuloma, which is predominantly osseous or pulmonary; Hand-Schûller-Christian’s disease, which involves multiple organ systems and, most typically, the skull base; and Letterer-Siwe’s disease, the most severe disease manifestation, which typically involves the abdominal viscera. This article reviews our current understanding of Langerhans cell histiocytosis by discussing the history, histology, etiology, and treatment of the disease. It focuses on the radiographic findings and imaging modalities that are the most useful in disease diagnosis and management.

Keywords

Langerhans cell histiocytosis Hand-Schûller-Christian’s disease Letterer-Siwe’s disease Eosinophilic granuloma Radiography MRI 

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Copyright information

© ISS 2006

Authors and Affiliations

  • Kevin Bradford Hoover
    • 1
  • Daniel I. Rosenthal
    • 2
  • Henry Mankin
    • 3
  1. 1.Musculoskeletal RadiologyMassachusetts General HospitalBostonUSA
  2. 2.Massachusetts General HospitalHarvard Medical SchoolBostonUSA
  3. 3.OrthopedicsMassachusetts General HospitalBostonUSA

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