Skeletal Radiology

, Volume 36, Issue 3, pp 237–247

Osteoblastomatosis of bone. A benign, multifocal osteoblastic lesion, distinct from osteoid osteoma and osteoblastoma, radiologically simulating a vascular tumor

  • Michael Kyriakos
  • Georges Y. El-Khoury
  • Douglas J. McDonald
  • Joseph A. Buckwalter
  • Murali Sundaram
  • Barry DeYoung
  • Michael P. O’Brien
Case Report


Two adult patients are described with multifocal osteolytic lesions radiologically simulating a vascular tumor. One patient had multiple bones involved. Histologically, the individual lesions had the features of the nidus of osteoid osteoma/osteoblastoma. A review of the English language medical literature yielded only one other reported case with similar features. The process is designated as osteoblastomatosis to indicate its bone-forming character, prominent osteoblast proliferation, and multiplicity. The cases are distinguished from multifocal/multicentric osteoid osteoma and osteoblastoma, and from benign and malignant vascular tumors.


Osteoid osteoma Osteoblastoma Hemangioendothelioma Angiomatosis Osteoblastoma-like lesion 


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Copyright information

© ISS 2006

Authors and Affiliations

  • Michael Kyriakos
    • 1
  • Georges Y. El-Khoury
    • 2
  • Douglas J. McDonald
    • 3
  • Joseph A. Buckwalter
    • 4
  • Murali Sundaram
    • 5
  • Barry DeYoung
    • 6
  • Michael P. O’Brien
    • 7
  1. 1.Division of Surgical Pathology, Campus Box 8118Washington University School of MedicineSt. LouisUSA
  2. 2.Department of Radiology, Roy J. and Lucille A. Carver School of MedicineUniversity of IowaIowa CityUSA
  3. 3.Department of Orthopaedic SurgeryWashington University School of MedicineSt. LouisUSA
  4. 4.Department of Orthopaedics, Roy J. and Lucille A. Carver School of MedicineUniversity of IowaIowa CityUSA
  5. 5.Department of RadiologyThe Cleveland Clinic FoundationClevelandUSA
  6. 6.Department of Pathology, Roy J. and Lucille A. Carver School of MedicineUniversity of IowaIowa CityUSA
  7. 7.Department of RadiologyUniversity of Wisconsin HospitalMadisonUSA

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