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Skeletal Radiology

, Volume 35, Issue 4, pp 233–239 | Cite as

Synovial sarcoma with radiological appearances of primitive neuroectodermal tumour/Ewing sarcoma: differentiation by molecular genetic studies

  • P. O’Donnell
  • T. C. Diss
  • J. Whelan
  • A. M. Flanagan
Case Report

Abstract

Synovial sarcoma (SS) arises in soft tissues but may invade adjacent bone. We describe a case of SS presenting as aggressive lysis of the proximal ulna, the imaging of which suggested a primary bone lesion. Needle biopsy showed a ‘small round blue cell tumour’, and a primitive neuroectodermal tumour (PNET)/Ewing sarcoma was suggested on the basis of the imaging appearances. The definitive diagnosis of synovial sarcoma was made following molecular genetic studies, which demonstrated a fusion product incorporating the genes SYT and SSX1. The importance of correct diagnosis to guide appropriate management, and, therefore, the necessity for molecular genetic studies, is discussed.

Keywords

Synovial sarcoma Ulna Ewing sarcoma Molecular genetics 

Notes

Acknowledgements

The molecular genetic analysis was funded by Cancer Research UK.

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Copyright information

© ISS 2005

Authors and Affiliations

  • P. O’Donnell
    • 1
  • T. C. Diss
    • 2
  • J. Whelan
    • 3
  • A. M. Flanagan
    • 2
    • 4
    • 5
  1. 1.Department of RadiologyRoyal National Orthopaedic Hospital NHS TrustStanmoreUK
  2. 2.Department of HistopathologyUniversity College HospitalLondonUK
  3. 3.Meyerstein Institute of OncologyUniversity College HospitalLondonUK
  4. 4.Department of HistopathologyRoyal National Orthopaedic HospitalStanmoreUK
  5. 5.Institute of OrthopaedicsUniversity CollegeLondonUK

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