Carbon-11-methionine positron emission tomography imaging of chordoma
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Chordoma is a rare malignant bone tumor that arises from notochord remnants. This is the first trial to investigate the utility of 11C-methionine (MET) positron emission tomography (PET) in the imaging of chordoma before and after carbon-ion radiotherapy (CIRT).
Design and patients
Fifteen patients with chordoma were investigated with MET-PET before and after CIRT and the findings analyzed visually and quantitatively. Tumor MET uptake was evaluated by tumor-to-nontumor ratio (T/N ratio).
In 12 (80%) patients chordoma was clearly visible in the baseline MET-PET study with a mean T/N ratio of 3.3±1.7. The MET uptake decreased significantly to 2.3±1.4 after CIRT (P<0.05). A significant reduction in tumor MET uptake of 24% was observed after CIRT. Fourteen (93%) patients showed no local recurrence after CIRT with a median follow-up time of 20 months.
This study has demonstrated that MET-PET is feasible for imaging of chordoma. MET-PET could provide important tumor metabolic information for the therapeutic monitoring of chordoma after CIRT.
KeywordsChordoma 11C-methionine PET Carbon ion radiotherapy Diagnosis
- 7.Krayenbuhl H, Yasargil MG. Cranial chordomas. Progr Neurol Surg 1975; 6:380–434.Google Scholar
- 22.Minn H, Clavo AC, Grenman R, Wahl RL. In vitro comparison of cell proliferation kinetics and uptake of tritiated fluorodeoxyglucose andl-methionine in squamous-cell carcinoma of the head and neck. J Nucl Med 1‘995; 36:252–258.Google Scholar
- 26.Weiss SW. WHO international histological classification of tumours. Histological typing of soft tissue tumours, 2nd edn. Berlin Heidelberg New York: Springer, 1994.Google Scholar
- 27.Langstrom B, Antoni G, Gullberg P, et al. Synthesis ofl-and d-[methy-11C]methionine. J Nucl Med 1987; 19:1037–1040.Google Scholar
- 29.Munzenrider JE, Liebsch NJ. Proton therapy for tumors of the skull base. Strahlenther Onkol 1999;175(Suppl 2):57–63.Google Scholar