Skeletal Radiology

, Volume 32, Issue 12, pp 724–727 | Cite as

Subungual melanoma with osteocartilaginous differentiation

  • H. Giele
  • K. Hollowood
  • C. L. M. H. Gibbons
  • D. J. Wilson
  • N. A. Athanasou
Case Report


Osteocartilaginous metaplasia is known to occur rarely in melanomas, particularly in subungual melanomas. We present a case of a calcified subungual soft tissue tumour in which biopsy of the lesion showed malignant round and spindle-shaped tumour cells, many of which were associated with the formation of cartilage and osteoid-like material. Subsequent resection showed clear histological evidence of a subungual melanoma. Tumour cells expressed S100, melan-A and neurone-specific enolase but were negative for HMB45. Diagnostic radiological and histological features and the nature of the osteocartilaginous differentiation within this lesion is discussed.


Melanoma Subungual Bone and cartilage differentiation 



The authors thank Dr. Alan Darby for help in diagnosing this lesion.


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Copyright information

© ISS 2003

Authors and Affiliations

  • H. Giele
    • 3
  • K. Hollowood
    • 3
  • C. L. M. H. Gibbons
    • 3
  • D. J. Wilson
    • 2
  • N. A. Athanasou
    • 1
  1. 1.Department of Pathology, University of OxfordNuffield Department of Orthopaedic Surgery, Nuffield Orthopaedic CentreOxfordUK
  2. 2.Department of Radiology, University of OxfordNuffield Orthopaedic CentreOxfordUK
  3. 3.Nuffield Department of Orthopaedic Surgery, University of OxfordNuffield Orthopaedic CentreOxfordUK

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