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Applied Microbiology and Biotechnology

, Volume 57, Issue 1–2, pp 13–19 | Cite as

Taxol: biosynthesis, molecular genetics, and biotechnological applications

  •  S. Jennewein
  •  R. Croteau
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Abstract.

Over the past decade, Taxol and its closely related structural analogue Taxotere have emerged as very important antitumor agents. Their widespread use in the treatment of a variety of cancer types, their likely approval for the treatment of additional forms of cancer, and their use at earlier stages of intervention will lead to increased demand for these drugs in the future. Because of yield considerations, Taxol and Taxotere are currently derived via semisynthesis from the advanced taxoid 10-deacetylbaccatin III, which must be isolated from yew (Taxus) trees. Thus, efforts are underway to produce Taxol (and other advanced taxoids for use in semisynthesis) by alternate, biotechnological means. This article provides a current overview of research on taxoid biosynthesis and an assessment of bioengineering applications for taxoid production in yew cell culture.

Keywords

Cell Culture Cancer Type Taxus Taxol Molecular Genetic 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  •  S. Jennewein
    • 1
  •  R. Croteau
    • 1
  1. 1.Institute of Biological Chemistry, Washington State Universtity, P.O. Box 646340, Pullman, WA 99164-6340, USA

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