Applied Microbiology and Biotechnology

, Volume 56, Issue 3, pp 289–295

Biotechnological production of itaconic acid

  •  Th. Willke
  •  K.-D. Vorlop

DOI: 10.1007/s002530100685

Cite this article as:
Willke, T. & Vorlop, KD. Appl Microbiol Biotechnol (2001) 56: 289. doi:10.1007/s002530100685


Itaconic acid (IA) is an unsaturated dicarbonic organic acid. It can easily be incorporated into polymers and may serve as a substitute for petrochemical-based acrylic or methacrylic acid. It is used at 1–5% as a comonomer in resins and also in the manufacture of synthetic fibres, in coatings, adhesives, thickeners and binders. The favoured production process is fermentation of carbohydrates by fungi, with a current market volume of about 15,000 t/a. Due to the high price of about US$4/kg, the use of IA is restricted. At present, the production rates do not exceed 1 g l–1 h–1, accompanied by product concentrations of about 80 g l–1. New biotechnology approaches, such as immobilisation techniques, screening programmes and genetic engineering, could lead to higher productivity. Also, the use of alternative substrates may reduce costs and thus open the market for new and increased applications.

Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  •  Th. Willke
    • 1
  •  K.-D. Vorlop
    • 1
  1. 1.Federal Agricultural Research Centre, Institute of Technology and Biosystems Engineering, Bundesallee 50, 38116 Braunschweig, Germany

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