Applied Microbiology and Biotechnology

, Volume 56, Issue 5–6, pp 676–680 | Cite as

Propionic acid production in an in situ cell retention bioreactor

  •  V. Goswami
  •  A. Srivastava
Original Paper

Abstract.

Continuous fermentations were conducted with in situ cell retention using spin filters (pore size 5 µm and 10 µm) for propionic acid production by Propionibacterium acidipropionici. Continuous fermentation with a 5-µm pore size spin filter resulted in 50% cell retention. Propionic acid productivity was enhanced (0.9 g l–1 h–1) by approximately four-fold compared to conventional batch fermentation (0.25 g l–1 h–1). The in situ cell retention (5-µm pore size spin filter) bioreactor was operated continuously and smoothly for 8 days at a dilution rate of D=0.05 h–1.

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Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  •  V. Goswami
    • 1
  •  A. Srivastava
    • 1
  1. 1.Department of Biochemical Engineering and Biotechnology, Indian Institute of Technology Delhi, Hauz Khas, New Delhi 110016, India

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