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Applied Microbiology and Biotechnology

, Volume 104, Issue 3, pp 907–914 | Cite as

Specific heavy metal/metalloid sensors: current state and perspectives

  • Hyojin Kim
  • Geupil Jang
  • Youngdae YoonEmail author
Mini-Review
  • 74 Downloads

Abstract

Heavy metal(loid)s play pivotal roles in regulating physiological and developmental aspects in living organisms depending on their concentration. For example, a trace amount of heavy metal(loid)s is essential for living organisms, but heavy metal(loid)s in high concentrations negatively affect their physiology and development. Because of rapid industrial developments, heavy metal(loid)s have been accumulating in environmental systems, thereby becoming a threat to human health and the earth’s ecosystem. Thus, the development of tools to quantify and monitor heavy metal(loid)s in environmental systems has become essential. Typically, risk has been determined through instrument-based analysis, regardless of the shortcomings regarding expense and duration. Nowadays, the need for alternative tools, besides instrumental analysis, to detect heavy metals has prompted the development of new techniques, and many different methods have been reported from various research areas, including new techniques based on electrochemistry and biological systems. Nonetheless, it seems that the gap between laboratory and fieldwork is still greater than it should be when it comes to applying these systems. In this mini-review, we discuss the current status of heavy metals/metalloid detection techniques, with an emphasis on biosensors. Moreover, we discuss the advantages and disadvantages as well as the mechanisms behind newly developed sensors and make suggestions to improve applicability and to develop new objective targeting sensors. Although many different types of metal(loid) sensors are available, we focused on metal sensors based on biological systems. Additionally, we suggest potent approaches to developing new biosensor systems based on current metal sensor mechanisms.

Keywords

Heavy metal sensors Chemosensors Electrochemical-based sensors Bacterial cell-based sensors Metalloregulators Split-protein systems 

Notes

Funding information

This study was supported by the Basic Science Research Program of the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT, and Future Planning (NRF-2017R1E1A1A01073894 to Y. Y.).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethics statement

This article does not contain any studies with human participants or animals performed by any of the authors.

References

  1. Acha V, Andrews T, Huang Q, Sardar DK, Hornsby PJ (2010) Tissue-based biosensors recognition receptors in biosensors. Springer, Germany, pp 365–381Google Scholar
  2. Bansod B, Kumar T, Thakur R, Rana S, Singh I (2017) A review on various electrochemical techniques for heavy metal ions detection with different sensing platforms. Biosens Bioelectron 94:443–455PubMedGoogle Scholar
  3. Belkin S (2003) Microbial whole-cell sensing systems of environmental pollutants. Curr Opin Microbiol 6(3):206–212PubMedGoogle Scholar
  4. Brown NL, Stoyanov JV, Kidd SP, Hobman JL (2003) The MerR family of transcriptional regulators. FEMS Microbiol Rev 27(2-3):145–163PubMedGoogle Scholar
  5. Brutesco C, Prévéral S, Escoffier C, Descamps EC, Prudent E, Cayron J, Dumas L, Ricquebourg M, Adryanczyk-Perrier G, de Groot A (2017) Bacterial host and reporter gene optimization for genetically encoded whole cell biosensors. Environ Sci Pollut Res 24(1):52–65Google Scholar
  6. Cabantous S, Nguyen HB, Pedelacq J-D, Koraïchi F, Chaudhary A, Ganguly K, Lockard MA, Favre G, Terwilliger TC, Waldo GS (2013) A new protein-protein interaction sensor based on tripartite split-GFP association. Sci Rep 3:2854PubMedPubMedCentralGoogle Scholar
  7. Carlson ED, Gan R, Hodgman CE, Jewett MC (2012) Cell-free protein synthesis: applications come of age. Biotechnol Adv 30(5):1185–1194PubMedGoogle Scholar
  8. Chen P, Greenberg B, Taghavi S, Romano C, van der Lelie D, He C (2005) An exceptionally selective lead (II)-regulatory protein from ralstonia metallidurans: development of a fluorescent lead (II) Probe. Angew Chem Int Ed 44(18):2715–2719Google Scholar
  9. Chen P, He C (2004) A general strategy to convert the MerR family proteins into highly sensitive and selective fluorescent biosensors for metal ions. J Am Chem Soc 126(3):728–729PubMedGoogle Scholar
  10. Choi M, Kim M, Lee KD, Han K-N, Yoon I-A, Chung H-J, Yoon J (2001) A new reverse PET chemosensor and its chelatoselective aromatic cadmiation. Org Lett 3(22):3455–3457PubMedGoogle Scholar
  11. Chow E, Gooding JJ (2006) Peptide modified electrodes as electrochemical metal ion sensors. Electroanalysis 18(15):1437–1448Google Scholar
  12. Degani Y, Heller A (1987) Direct electrical communication between chemically modified enzymes and metal electrodes. I. Electron transfer from glucose oxidase to metal electrodes via electron relays, bound covalently to the enzyme. J Phys Chem 91(6):1285–1289Google Scholar
  13. Dujols V, Ford F, Czarnik AW (1997) A long-wavelength fluorescent chemodosimeter selective for Cu (II) ion in water. J Am Chem Soc 119(31):7386–7387Google Scholar
  14. Fabbrizzi L, Licchelli M, Pallavicini P, Perotti A, Taglietti A, Sacchi D (1996) Fluorescent sensors for transition metals based on electron-transfer and energy-transfer mechanisms. Chem Eur J 2(1):75–82Google Scholar
  15. Fernandez-López R, Ruiz R, de la Cruz F, Moncalián G (2015) Transcription factor-based biosensors enlightened by the analyte. Front Microbiol 6:648PubMedPubMedCentralGoogle Scholar
  16. Gumpu MB, Sethuraman S, Krishnan UM, Rayappan JBB (2015) A review on detection of heavy metal ions in water–an electrochemical approach. Sens Actuators B-Chem 213:515–533Google Scholar
  17. Hao S, Li J, Li Y, Zhang Y, Hu G (2016) Facile synthesis of a 3D MnO 2 nanowire/Ni foam electrode for the electrochemical detection of Cu (ii). Anal Methods 8(24):4919–4925Google Scholar
  18. Harkins M, Porter AJR, Paton GI (2004) The role of host organism, transcriptional switches and reporter mechanisms in the performance of Hg-induced biosensors. J Appl Microbiol 97(6):1192–1200PubMedGoogle Scholar
  19. Harms H, Wells MC, van der Meer JR (2006) Whole-cell living biosensors—are they ready for environmental application? Appl Microbiol Biotechnol 70(3):273–280PubMedGoogle Scholar
  20. He W, Yuan S, Zhong W-H, Siddikee MA, Dai C-C (2016) Application of genetically engineered microbial whole-cell biosensors for combined chemosensing. Appl Microbiol Biotechnol 100(3):1109–1119PubMedGoogle Scholar
  21. Heldwein EEZ, Brennan RG (2001) Crystal structure of the transcription activator BmrR bound to DNA and a drug. Nature 409(6818):378–382PubMedGoogle Scholar
  22. Islam SK, Vijayaraghavan R, Zhang M, Ripp S, Caylor SD, Weathers B, Moser S, Terry S, Blalock BJ, Sayler GS (2007) Integrated circuit biosensors using living whole-cell bioreporters. IEEE Transactions on Circuits and Systems I: Reg Papers 54(1):89–98Google Scholar
  23. Ivask A, Green T, Polyak B, Mor A, Kahru A, Virta M, Marks R (2007) Fibre-optic bacterial biosensors and their application for the analysis of bioavailable Hg and As in soils and sediments from Aznalcollar mining area in Spain. Biosens Bioelectron 22(7):1396–1402PubMedGoogle Scholar
  24. Järup L (2003) Hazards of heavy metal contamination. Br Med Bull 68(1):167–182PubMedGoogle Scholar
  25. Jeong Y, Yoon J (2012) Recent progress on fluorescent chemosensors for metal ions. Inorg Chim Acta 381:2–14Google Scholar
  26. Kang Y, Lee W, Jang G, Kim B-G, Yoon Y (2018a) Modulating the sensing properties of Escherichia coli-based bioreporters for cadmium and mercury. Appl Microbiol Biotechnol 102(11):4863–4872PubMedGoogle Scholar
  27. Kang Y, Lee W, Kim S, Jang G, Kim B-G, Yoon Y (2018b) Enhancing the copper-sensing capability of Escherichia coli-based whole-cell bioreporters by genetic engineering. Appl Microbiol Biotechnol 102(3):1513–1521PubMedGoogle Scholar
  28. Katzen F, Chang G, Kudlicki W (2005) The past, present and future of cell-free protein synthesis. Trends Biotechnol 23(3):150–156PubMedGoogle Scholar
  29. Keefe MH, Benkstein KD, Hupp JT (2000) Luminescent sensor molecules based on coordinated metals: a review of recent developments. Coord Chem Rev 205(1):201–228Google Scholar
  30. Kim H, Lee W, Yoon Y (2019) Heavy metal (loid) biosensor based on split-enhanced green fluorescent protein: development and characterization. Appl Microbiol Biotechnol 103(15):6345–6352PubMedGoogle Scholar
  31. Krämer R (1998) Fluorescent chemosensors for Cu2+ ions: fast, selective, and highly sensitive. Angew Chem Int Ed 37(6):772–773Google Scholar
  32. Kwon JY, Jang YJ, Lee YJ, Kim KM, Seo MS, Nam W, Yoon J (2005) A highly selective fluorescent chemosensor for Pb2+. J Am Chem Soc 127(28):10107–10111PubMedGoogle Scholar
  33. Lee W, Kim H, Kang Y, Lee Y, Yoon Y (2019) A biosensor platform for metal detection based on enhanced green fluorescent protein. Sensors 19(8):1846Google Scholar
  34. Liao VH-C, Chien M-T, Tseng Y-Y, Ou K-L (2006) Assessment of heavy metal bioavailability in contaminated sediments and soils using green fluorescent protein-based bacterial biosensors. Environ Pollut 142(1):17–23PubMedGoogle Scholar
  35. Mahr R, Frunzke J (2016) Transcription factor-based biosensors in biotechnology: current state and future prospects. Appl Microbiol Biotechnol 100(1):79–90PubMedGoogle Scholar
  36. Martin S, Griswold W (2009) Human health effects of heavy metals. Environ Sci Technol briefs for citizens 15:1–6Google Scholar
  37. Nie Z, Nijhuis CA, Gong J, Chen X, Kumachev A, Martinez AW, Narovlyansky M, Whitesides GM (2010) Electrochemical sensing in paper-based microfluidic devices. Lab Chip 10(4):477–483PubMedGoogle Scholar
  38. Paulmurugan R, Gambhir S (2003) Monitoring protein− protein interactions using split synthetic renilla luciferase protein-fragment-assisted complementation. Anal Chem 75(7):1584–1589PubMedPubMedCentralGoogle Scholar
  39. Pennella MA, Shokes JE, Cosper NJ, Scott RA, Giedroc DP (2003) Structural elements of metal selectivity in metal sensor proteins. Proc Natl Acad Sci 100(7):3713–3718PubMedGoogle Scholar
  40. Reay RJ, Flannery AF, Storment CW, Kounaves SP, Kovacs GT (1996) Microfabricated electrochemical analysis system for heavy metal detection. Sens Actuator B-Chem 34(1-3):450–455Google Scholar
  41. Riman D, Jirovsky D, Hrbac J, Prodromidis MI (2015) Green and facile electrode modification by spark discharge: Bismuth oxide-screen printed electrodes for the screening of ultra-trace Cd (II) and Pb (II). Electrochem Commun 50:20–23Google Scholar
  42. Robbens J, Dardenne F, Devriese L, De Coen W, Blust R (2010) Escherichia coli as a bioreporter in ecotoxicology. Appl Microbiol Biotechnol 88(5):1007–1025PubMedGoogle Scholar
  43. Ruger P, Ambrosius D, Schmidt B, Sluka P, Guder H-J, Kopetzki E (1998) Electrochemical sensor containing an enzyme linked to binding molecules bound to a noble metal surface. Google PatentsGoogle Scholar
  44. Shekhawat SS, Ghosh I (2011) Split-protein systems: beyond binary protein–protein interactions. Curr Opin Chem Biol 15(6):789–797PubMedPubMedCentralGoogle Scholar
  45. Shemer B, Belkin S (2019) Microbial biosensors for the detection of organic pollutants. Handbook Cell Biosen:1–24Google Scholar
  46. Sugunan A, Thanachayanont C, Dutta J, Hilborn J (2005) Heavy-metal ion sensors using chitosan-capped gold nanoparticles. Sci Technol Adv Mater 6(3-4):335Google Scholar
  47. Sun Y, Zhao X, Zhang D, Ding A, Chen C, Huang WE, Zhang H (2017) New naphthalene whole-cell bioreporter for measuring and assessing naphthalene in polycyclic aromatic hydrocarbons contaminated site. Chemosphere 186:510–518PubMedGoogle Scholar
  48. Thevenot DR, Toth K, Durst RA, Wilson GS (1999) Electrochemical biosensors: recommended definitions and classification. Pure Appl Chem 71(12):2333–2348Google Scholar
  49. Waheed A, Mansha M, Ullah N (2018) Nanomaterials-based electrochemical detection of heavy metals in water: current status, challenges and future direction. TRAC Trend Anal Chem 105:37–51Google Scholar
  50. Waldron KJ, Rutherford JC, Ford D, Robinson NJ (2009) Metalloproteins and metal sensing. Nature 460(7257):823–830PubMedGoogle Scholar
  51. Wang J, Larson D, Foster N, Armalis S, Lu J, Rongrong X, Olsen K, Zirino A (1995) Remote electrochemical sensor for trace metal contaminants. Anal Chem 67(8):1481–1485Google Scholar
  52. Wing Fen Y, Mahmood Mat Yunus W (2013) Surface plasmon resonance spectroscopy as an alternative for sensing heavy metal ions: a review. Sens Rev 33(4):305–314Google Scholar
  53. Winkler JD, Bowen CM, Michelet V (1998) Photodynamic fluorescent metal ion sensors with parts per billion sensitivity. J Am Chem Soc 120(13):3237–3242Google Scholar
  54. Wu J, Liu W, Ge J, Zhang H, Wang P (2011) New sensing mechanisms for design of fluorescent chemosensors emerging in recent years. Chem Soc Rev 40(7):3483–3495PubMedGoogle Scholar
  55. Xu Z, Kim G-H, Han SJ, Jou MJ, Lee C, Shin I, Yoon J (2009) An NBD-based colorimetric and fluorescent chemosensor for Zn2+ and its use for detection of intracellular zinc ions. Tetrahedron 65(11):2307–2312Google Scholar
  56. Xu Z, Yoon J, Spring DR (2010) Fluorescent chemosensors for Zn2+. Chem Soc Rev 39(6):1996–2006PubMedGoogle Scholar
  57. Yoon Y, Kang Y, Lee W, Oh K-C, Jang G, Kim B-G (2018) Modulating the properties of metal-sensing whole-cell bioreporters by interfering with Escherichia coli metal homeostasis. J Microbiol Biotechnol 28(2):323–329PubMedGoogle Scholar
  58. Yoon Y, Kim S, Chae Y, Kang Y, Lee Y, Jeong S-W, An Y-J (2016) Use of tunable whole-cell bioreporters to assess bioavailable cadmium and remediation performance in soils. PLoS One 11(5):e0154506PubMedPubMedCentralGoogle Scholar
  59. Zeng S, Yong K-T, Roy I, Dinh X-Q, Yu X, Luan F (2011) A review on functionalized gold nanoparticles for biosensing applications. Plasmonics 6(3):491Google Scholar
  60. Zhang X-B, Kong R-M, Lu Y (2011) Metal ion sensors based on DNAzymes and related DNA molecules. Annu Rev Anal Chem 4:105–128Google Scholar
  61. Zhao Q, Gan Z, Zhuang Q (2002) Electrochemical sensors based on carbon nanotubes. Electroanal 14(23):1609–1613Google Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Environmental Health ScienceKonkuk UniversitySeoulRepublic of Korea
  2. 2.School of Biological Sciences and TechnologyChonnam National UniversityGwangjuRepublic of Korea

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