Advances in research on Cordyceps militaris degeneration
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As a highly valued fungus, Cordyceps militaris has been widely used all over the world. Although the wild resources of C. militaris are limited, the fruiting bodies of C. militaris have been successfully cultivated on a large-scale. However, the high-frequency degeneration of C. militaris during subculture and preservation seriously limits the development of the C. militaris industry. How to solve the degeneration of C. militaris has become an unsolved bottleneck problem throughout the whole Cordyceps industry. The aim of this review is to illustrate the phenotypic changes after the degeneration of C. militaris, focusing on the causes (including environmental factors and genetic variation) of C. militaris degeneration. Moreover, genetic variation is the root cause of the degeneration of C. militaris strains. Measures to prevent the degeneration of C. militaris are also discussed in this review. This paper will increase understanding of the degeneration mechanism of C. militaris, provide a reference for solving the degeneration problem of C. militaris, and lay a foundation for promoting the sustainable development of C. militaris.
KeywordsFilamentous fungi Degeneration mechanism Fruiting body Genetic variation Subculture Cordyceps militaris
This study was funded by the National Natural Science Foundation of China-Henan Joint Fund (grant number U1604234) and the National Natural Science Foundation of China (grant number 31572178).
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
This article does not contain any studies with human participants or animals performed by any of the authors.
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