Applied Microbiology and Biotechnology

, Volume 103, Issue 19, pp 7843–7867 | Cite as

Diversity of potentially exploitable pharmacological activities of the highly prized edible medicinal fungus Antrodia camphorata

  • Caicheng Wang
  • Weiwei Zhang
  • Jack Ho Wong
  • Tzibun Ng
  • Xiujuan YeEmail author


Antrodia camphorata, also known as A. cinnamomea, is a precious medicinal basidiomycete fungus endemic to Taiwan. This article summarizes the recent advances in research on the multifarious pharmacological effects of A. camphorata. The mushroom exhibits anticancer activity toward a large variety of cancers including breast, cervical, ovarian, prostate, bladder, colorectal, pancreatic, liver, and lung cancers; melanoma; leukemia; lymphoma; neuroblastoma; and glioblastoma. Other activities encompass antiinflammatory, antiatopic dermatitis, anticachexia, immunoregulatory, antiobesity, antidiabetic, antihyperlipidemic, antiatherosclerotic, antihypertensive, antiplatelet, antioxidative, antiphotodamaging, hepatoprotective, renoprotective, neuroprotective, testis protecting, antiasthmatic, osteogenic, osteoprotective, antiviral, antibacterial, and wound healing activities. This review aims to provide a reference for further development and utilization of this highly prized mushroom.


Antrodia camphorata Anticancer Antiinflammatory Antileukemia Hepatoprotective Neuroprotective 



This work was supported by the University-Industry Cooperation Project of Fujian Science and Technology Department (2018N5005). We also gratefully acknowledge the award of HMRF research grant (no. 12131221) from Food and Health Bureau, the Government of Hong Kong Special Administrative Region, and a grant from National Natural Science Foundation of China (no. 81471927).

Compliance with ethical standards

Conflict of interest

The authors declare that there is no conflict of interest.

Ethical statement

This work does not contain any studies with human participants or animals performed by any of the authors.


  1. Ahmad MF (2018) Ganoderma lucidum: persuasive biologically active constituents and their health endorsement. Biomed Pharmacother 107:507–519. Google Scholar
  2. Amin ZA, Ali HM, Alshawsh MA, Darvish PH, Abdulla MA (2015) Application of Antrodia camphorata promotes rat’s wound healing in vivo and facilitates fibroblast cell proliferation in vitro. Evid-Based Compl Alt 2015:317693
  3. Ao ZH, Xu ZH, Lu ZM, Xu HY, Zhang XM, Dou WF (2009) Niuchangchih (Antrodia camphorata) and its potential in treating liver diseases. J Ethnopharmacol 121(2):194–212. Google Scholar
  4. Bamodu OA, Yang CK, Cheng WH, Tzeng DTW, Kuo KT, Huang CC, Deng L, Hsiao M, Lee WH, Yeh CT (2018) 4-Acetyl-antroquinonol B suppresses SOD2-enhanced cancer stem cell-like phenotypes and chemoresistance of colorectal cancer cells by inducing hsa-miR-324 re-expression. Cancers 10(8).
  5. Buccini M, Punch KA, Kaskow B, Flematti GR, Skelton BW, Abraham LJ, Piggott MJ (2014) Ethynylbenzenoid metabolites of Antrodia camphorata: synthesis and inhibition of TNF expression. Org Biomol Chem 12(7):1100–1113. Google Scholar
  6. Chang JM, Lee YR, Hung LM, Liu SY, Kuo MT, Wen WC, Chen P (2011) An extract of Antrodia camphorata mycelia attenuates the progression of nephritis in systemic lupus erythematosus-prone NZB/W F1mice. Evid-Based Compl Alt:1–7.
  7. Chang JB, Wu MF, Lu HF, Chou J, Au MK, Liao NC, Chang CH, Huang YP, Wu CT, Chung JG (2013) Toxicological evaluation of Antrodia cinnamomea in BALB/c mice. In Vivo 27(6):739–745Google Scholar
  8. Chang TC, Yeh CT, Adebayo BOW, Lin YC, Deng L, Rao YK, Huang CC, Lee WH, Wu ATH, Hsiao M, Wu CH, Wang LS, Tzeng YM (2015a) 4-Acetylantroquinonol B inhibits colorectal cancer tumorigenesis and suppresses cancer stem-like phenotype. Toxicol Appl Pharm 288(2):258–268. Google Scholar
  9. Chang WH, Chen MC, Cheng IH (2015b) Antroquinonol lowers brain amyloid-beta levels and improves spatial learning and memory in a transgenic mouse model of Alzheimer’s disease. Sci Rep 5:15067. Google Scholar
  10. Chang Y, Zhang M, Jiang Y, Liu Y, Luo H, Hao C, Zeng P, Zhang L (2017a) Preclinical and clinical studies of Coriolus versicolor polysaccharopeptide as an immunotherapeutic in China. Discov Med 23(127):207–219Google Scholar
  11. Chang YY, Liu YC, Kuo YH, Lin YL, Wu YHS, Chen JW, Chen YC (2017b) Effects of antrosterol from Antrodia camphorata submerged whole broth on lipid homeostasis, antioxidation, alcohol clearance, and anti-inflammation in livers of chronic-alcohol fed mice. J Ethnopharmacol 202:200–207. Google Scholar
  12. Chang CJ, Lu CC, Lin CS, Martel J, Ko YF, Ojcius DM, Wu TR, Tsai YH, Yeh TS, Lu JJ, Lai HC, Young JD (2018) Antrodia cinnamomea reduces obesity and modulates the gut microbiota in high-fat diet-fed mice. Int J Obesity 42(2):231–243. Google Scholar
  13. Chen YC, Liu YL, Li FY, Chang CL, Wang SY, Lee KY, Li SL, Chen YP, Jinn TR, Tzen JT (2011) Antcin A, a steroid-like compound from Antrodia camphorata, exerts anti-inflammatory effect via mimicking glucocorticoids. Acta Pharmacol Sin 32(7):904–911. Google Scholar
  14. Chen YY, Liu FC, Wu TS, Sheu MJ (2015) Antrodia cinnamomea inhibits migration in human hepatocellular carcinoma cells: the role of ERp57 and PGK-1. Am J Chin Med 43(8):1671–1696. Google Scholar
  15. Chen JR, Ko J, Yeh WJ, Huang WC, Yang HY (2018a) Renoprotective effects of antroquinonol in rats with N (omega)-nitro-l-arginine methyl ester-induced hypertension. Nutrients 10(10).
  16. Chen MC, Hsu WL, Chou TC (2018b) Anti-cachectic effect of Antrodia cinnamomea extract in lung tumor-bearing mice under chemotherapy. Oncotarget 9(28):19584–19596. Google Scholar
  17. Chen PC, Chen CC, Ker YB, Chang CH, Chyau CC, Hu ML (2018c) Anti-metastatic effects of antrodan with and without cisplatin on Lewis lung carcinomas in a mouse xenograft model. Int J Mol Sci 19(6).
  18. Chen SN, Chang CS, Chen S, Soni M (2018d) Subchronic toxicity and genotoxicity studies of Antrodia mushroom beta-glucan preparation. Regul Toxicol Pharmacol 92:429–438. Google Scholar
  19. Chen SY, Lee YR, Hsieh MC, Omar HA, Teng YN, Lin CY, Hung JH (2018e) Enhancing the anticancer activity of Antrodia cinnamomea in hepatocellular carcinoma cells via cocultivation with ginger: the impact on cancer cell survival pathways. Front Pharmacol 9:780
  20. Chen YF, Chang CH, Huang ZN, Su YC, Chang SJ, Jan JS (2018f) The JAK inhibitor antcin H exhibits direct anticancer activity while enhancing chemotherapy against LMP1-expressed lymphoma. Leukemia & lymphoma:1–11.
  21. Chen YY, Lo CP, Lin CC, Hsieh YH (2018g) Effects of Taiwanofungus camphoratus on non-specific and specific immune activities in mice. Mycology 9(2):129–135. Google Scholar
  22. Chen JH, Wu ATH, Tzeng DTW, Huang CC, Tzeng YM, Chao TY (2019a) Antrocin, a bioactive component from Antrodia cinnamomea, suppresses breast carcinogenesis and stemness via downregulation of beta-catenin/Notch1/Akt signaling. Phytomedicine 52:70–78. Google Scholar
  23. Chen L, Wang Z, Zhang B, Ge M, Ng H, Niu Y, Liu L (2019b) Production, structure and morphology of exopolysaccharides yielded by submerged fermentation of Antrodia cinnamomea. Carbohydr Polym 205:271–278. Google Scholar
  24. Chen YA, Tzeng DTW, Huang YP, Lin CJ, Lo UG, Wu CL, Lin H, Hsieh JT, Tang CH, Lai CH (2019c) Antrocin sensitizes prostate cancer cells to radiotherapy through inhibiting PI3K/AKT and MAPK signaling pathways. Cancers 11(1).
  25. Chen YC, Liu YC, El-Shazly M, Wu TY, Chang JG, Wu YC (2019d) Antrodia cinnamomea, a treasured medicinal mushroom, induces growth arrest in breast cancer cells, T47D cells: new mechanisms emerge. Int J Mol Sci 20(4).
  26. Cheng PC, Hsu CY, Chen CC, Lee KM (2008) In vivo immunomodulatory effects of Antrodia camphorata polysaccharides in a T1/T2 doubly transgenic mouse model for inhibiting infection of Schistosoma mansoni. Toxicol Appl Pharm 227(2):291–298.
  27. Cheng PC, Huang CC, Chiang PF, Lin CN, Li LL, Lee TW, Lin B, Chen IC, Chang KW, Fan CK, Luo TY (2014) Radioprotective effects of Antrodia cinnamomea are enhanced on immune cells and inhibited on cancer cells. Int J Radiat Biol 90(10):841–852. Google Scholar
  28. Chiang PC, Lin SC, Pan SL, Kuo CH, Tsai IL, Kuo MT, Wen WC, Chen P, Guh JH (2010) Antroquinonol displays anticancer potential against human hepatocellular carcinoma cells: a crucial role of AMPK and mTOR pathways. Biochem Pharmacol 79(2):162–171. Google Scholar
  29. Chiu CC, Chen CC, Huang HY, Chen CC, Lin TW, Chyau CC, Chiou YL, WS K (2017) Complementary efficacy of Antrodia cinnamomea mycelia on patients with chronic hepatitis C virus infection: a randomized controlled pilot clinical study. J Food Nutr Res 5(7):481–489Google Scholar
  30. Chou KC, Wu HL, Lin PY, Yang SH, Chang TL, Sheu F, Chen KH, Chiang BH (2019) 4-Hydroxybenzoic acid serves as an endogenous ring precursor for antroquinonol biosynthesis in Antrodia cinnamomea. Phytochemistry 161:97–106. Google Scholar
  31. Chung CH, Yeh SC, Chen CJ, Lee KT (2014) Coenzyme Q0 from Antrodia cinnamomea in submerged cultures induces reactive oxygen species-mediated apoptosis in A549 human lung cancer cells. Evid-Based Compl Alt 2014:246748
  32. da Silva de Souza AC, Correa VG, Goncalves GA, Soares AA, Bracht A, Peralta RM (2017) Agaricus blazei bioactive compounds and their effects on human health: benefits and controversies. Curr Pharm Design 23(19):2807–2834. Google Scholar
  33. Deng JS, Huang SS, Lin TH, Lee MM, Kuo CC, Sung PJ, Hou WC, Huang GJ, Kuo YH (2013) Analgesic and anti-inflammatory bioactivities of eburicoic acid and dehydroeburicoic acid isolated from Antrodia camphorata on the inflammatory mediator expression in mice. J Agric Food Chem 61(21):5064–5071. Google Scholar
  34. Du YC, Chang FR, Wu TY, Hsu YM, El-Shazly M, Chen CF, Sung PJ, Lin YY, Lin YH, Wu YC, Lu MC (2012) Antileukemia component, dehydroeburicoic acid from Antrodia camphorata induces DNA damage and apoptosis in vitro and in vivo models. Phytomedicine 19(8–9):788–796. Google Scholar
  35. Fa KN, Yang CM, Chen PC, Lee YY, Chyau CC, Hu ML (2015) Anti-metastatic effects of antrodan, the Antrodia cinnamomea mycelia glycoprotein, in lung carcinoma cells. Int J Biol Macromol 74:476–482. Google Scholar
  36. Geethangili M, Tzeng YM (2011) Review of pharmacological effects of Antrodia camphorata and its bioactive compounds. Evid-Based Compl Alt 1(17).
  37. Geng Y, Wang J, Xie MF, Lu ZM, Xu HY, Shi JS, Xu ZH (2014) Screening and isolation for anti-hepatofibrotic components from medicinal mushrooms using TGF-beta 1-induced live fibrosis in hepatic stellate cells. Int J Med Mushrooms 16(6):529–539Google Scholar
  38. Gokila Vani M, Kumar KJ, Liao JW, Chien SC, Mau JL, Chiang SS, Lin CC, Kuo YH, Wang SY (2013) Antcin C from Antrodia cinnamomea protects liver cells against free radical-induced oxidative stress and apoptosis in vitro and in vivo through Nrf2-dependent mechanism. Evid Based Complement Alternat Med 2013:296082. Google Scholar
  39. Guan C, Li Q, Song X, Xu W, Li L, Xu A (2017) Antroquinonol exerts immunosuppressive effect on CD8(+) T cell proliferation and activation to resist depigmentation induced by H2O2. Oxidative Med Cell Longev 2017:9303054
  40. He YC, Lu ZH, Shi P, Hao JC, Zhao ZJ, Xie HT, Mao P, Chen SJ (2016) Anti-herpes simplex virus activities of bioactive extracts from Antrodia camphorata mycelia. Antivir Ther 21(5):377–383. Google Scholar
  41. He X, Wang X, Fang J, Chang Y, Ning N, Guo H, Huang L, Huang X, Zhao Z (2017) Polysaccharides in Grifola frondosa mushroom and their health promoting properties: a review. Int J Biol Macromol 101:910–921. Google Scholar
  42. He Y, Li X, Hao C, Zeng P, Zhang M, Liu Y, Chang Y, Zhang L (2018) Grifola frondosa polysaccharide: a review of antitumor and other biological activity studies in China. Discov Med 25(138):159–176Google Scholar
  43. Ho CL, Wang JL, Lee CC, Cheng HY, Wen WC, Cheng HHY, Chen MCM (2014) Antroquinonol blocks Ras and Rho signaling via the inhibition of protein isoprenyltransferase activity in cancer cells. Biomed Pharmacother 68(8):1007–1014. Google Scholar
  44. Hseu YC, Chang WC, Hseu YT, Lee CY, Yech YJ, Chen PC, Chen JY, Yang HL (2002) Protection of oxidative damage by aqueous extract from Antrodia camphorata mycelia in normal human erythrocytes. Life Sci 71(4):469–482. Google Scholar
  45. Hseu YC, Chen SC, Yech YJ, Wang L, Yang HL (2008) Antioxidant activity of Antrodia camphorata on free radical-induced endothelial cell damage. J Ethnopharmacol 118(2):237–245. Google Scholar
  46. Hseu YC, Tsou HT, Kumar KJS, Lin KY, Chang HW, Yang HL (2012) The antitumor activity of Antrodia camphorata in melanoma cells: modulation of Wnt/beta-catenin signaling pathways. Evid-Based Compl Alt 2012:197309
  47. Hseu YC, Chang GR, Pan JY, Rajendran P, Mathew DC, Li ML, Liao JW, Chen WTL, Yang HL (2019) Antrodia camphorata inhibits epithelial-to-mesenchymal transition by targeting multiple pathways in triple-negative breast cancers. J Cell Physiol 234(4):4125–4139. Google Scholar
  48. Hsiao CY, Hsu YJ, Tung YT, Lee MC, Huang CC, Hsieh CC (2018) Effects of Antrodia camphorata and Panax ginseng supplementation on anti-fatigue properties in mice. J Vet Med Sci 80(2):284–291. Google Scholar
  49. Hsieh YL, Wu SP, Fang LW, Hwang TS (2015) Effects of Antrodia camphorata extracts on anti-oxidation, anti-mutagenesis and protection of DNA against hydroxyl radical damage. Bmc Complem Altern M 15.
  50. Hsu CY, Sulake RS, Huang PK, Shih HY, Sie HW, Lai YK, Chen C, Weng CF (2015) Synthetic (+)-antroquinonol exhibits dual actions against insulin resistance by triggering AMP kinase and inhibiting dipeptidyl peptidase IV activities. Br J Pharmacol 172(1):38–49. Google Scholar
  51. Hu Y, Zhu M, Tian G, Zhao L, Wang H, Ng TB (2017) Isolation of a protease-resistant and pH-stable alpha-galactosidase displaying hydrolytic efficacy toward raffinose family oligosaccharides from the button mushroom Agaricus bisporus. Int J Biol Macromol 104:576–583. Google Scholar
  52. Huang CC, Cheng HH, Wang JL, Cheng JS, Chai KL, Fang YC, Kuo CC, Chu ST, Ho CM, Lin KL, Tsai JY, Jan CR (2009) Effects of Antrodia camphorata extracts on the viability, apoptosis, [Ca2+](i), and MAPKs phosphorylation of OC2 human oral cancer cells. Chin J Physiol 52(3):128–135. Google Scholar
  53. Huang CH, Chang CC, Lin CM, Wang ST, Wu MT, Li EIC, Chang HC, Lin CC (2010) Promoting effect of Antrodia camphorata as an immunomodulating adjuvant on the antitumor efficacy of HER-2/neu DNA vaccine. Cancer Immunol Immun 59(8):1259–1272. Google Scholar
  54. Huang GJ, Deng JS, Huang SS, Lee CY, Hou WC, Wang SY, Sung PJ, Kuo YH (2013) Hepatoprotective effects of eburicoic acid and dehydroeburicoic acid from Antrodia camphorata in a mouse model of acute hepatic injury. Food Chem 141(3):3020–3027. Google Scholar
  55. Huang TT, Wu SP, Chong KY, Ojcius DM, Ko YF, Wu YH, Wu CY, Lu CC, Martel J, Young JD, Lai HC (2014a) The medicinal fungus Antrodia cinnamomea suppresses inflammation by inhibiting the NLRP3 inflammasome. J Ethnopharmacol 155(1):154–164. Google Scholar
  56. Huang Y, Lin XH, Qiao X, Ji S, Liu KD, Yeh CT, Tzeng YM, Guo D, Ye M (2014b) Antcamphins A-L, ergostanoids from Antrodia camphorata. J Nat Prod 77(1):118–124. Google Scholar
  57. Huang CY, Ju DT, Chang CF, Muralidhar Reddy P, Velmurugan BK (2017) A review on the effects of current chemotherapy drugs and natural agents in treating non-small cell lung cancer. Biomedicine 7(4):23–23. Google Scholar
  58. Huang TT, Lan YW, Chen CM, Ko YF, Ojcius DM, Martel J, Young JD, Chong KY (2019) Antrodia cinnamomea induces anti-tumor activity by inhibiting the STAT3 signaling pathway in lung cancer cells. Sci Rep 9(1).
  59. Jedinak A, Dudhgaonkar S, Wu QL, Simon J, Sliva D (2011) Anti-inflammatory activity of edible oyster mushroom is mediated through the inhibition of NF-kappa B and AP-1 signaling. Nutr J 10.
  60. Jiang J, Sliva D (2010) Novel medicinal mushroom blend suppresses growth and invasiveness of human breast cancer cells. Int J Oncol 37(6):1529–1536. Google Scholar
  61. Johnson A, Cheng SC, Tsou D, Kong ZL (2019) Attenuation of reproductive dysfunction in diabetic male rats with timber cultured Antrodia cinnamomea ethanol extract. Biomed Pharmacother 112:108684–108684. Google Scholar
  62. Kao ST, Kuo YH, Wang SD, Hong HJ, Lin LJ (2018) Analogous corticosteroids, 9A and EK100, derived from solid-state-cultured mycelium of Antrodia camphorata inhibit proinflammatory cytokine expression in macrophages. Cytokine 108:136–144. Google Scholar
  63. Ker YB, Peng CC, Chang WL, Chyau CC, Peng RY (2014) Hepatoprotective bioactivity of the glycoprotein, antrodan, isolated from Antrodia cinnamomea mycelia. PLoS One 9(4).
  64. Kumar KJ, Chu FH, Hsieh HW, Liao JW, Li WH, Lin JC, Shaw JF, Wang SY (2011a) Antroquinonol from ethanolic extract of mycelium of Antrodia cinnamomea protects hepatic cells from ethanol-induced oxidative stress through Nrf-2 activation. J Ethnopharmacol 136(1):168–177. Google Scholar
  65. Kumar VB, Yuan TC, Liou JW, Yang CJ, Sung PJ, Weng CF (2011b) Antroquinonol inhibits NSCLC proliferation by altering PI3K/mTOR proteins and miRNA expression profiles. Mutat Res-Fund Mol M 707(1–2):42–52. Google Scholar
  66. Kuo MC, Chang CY, Cheng TL, Wu MJ (2008) Immunomodulatory effect of Antrodia camphorata mycelia and culture filtrate. J Ethnopharmacol 120(2):196–203. Google Scholar
  67. Kuo YH, Lin CH, Shih CC (2015a) Antidiabetic and antihyperlipidemic properties of a triterpenoid compound, dehydroeburicoic acid, from Antrodia camphorata in vitro and in streptozotocin-induced mice. J Agric Food Chem 63(46):10140–10151.
  68. Kuo YH, Lin CH, Shih CC (2015b) Ergostatrien-3 beta-ol from Antrodia camphorata inhibits diabetes and hyperlipidemia in high-fat-diet treated mice via regulation of hepatic related genes, glucose transporter 4, and AMP-activated protein kinase phosphorylation. J Agric Food Chem 63(9):2479–2489. Google Scholar
  69. Kuo YH, Lin CH, Shih CC (2016a) Dehydroeburicoic acid from Antrodia camphorata prevents the diabetic and dyslipidemic state via modulation of glucose transporter 4, peroxisome proliferator-activated receptor alpha expression and AMP-activated protein kinase phosphorylation in high-fat-fed mice. Int J Mol Sci 17(6).
  70. Kuo YH, Lin TY, You YJ, Wen KC, Sung PJ, Chiang HM (2016b) Antiinflammatory and antiphotodamaging effects of ergostatrien-3 beta-ol, isolated from Antrodia camphorata, on hairless mouse skin. Molecules 21(9).
  71. Kuo TH, Kuo YH, Cho CY, Yao CJ, Lai GM, Chuang SE (2019) Protective effect of Antrodia cinnamomea extract against irradiation-induced acute hepatitis. Int J Mol Sci 20(4).
  72. Lavi I, Levinson D, Peri I, Nimri L, Hadar Y, Schwartz B (2010a) Orally administered glucans from the edible mushroom Pleurotus pulmonarius reduce acute inflammation in dextran sulfate sodium-induced experimental colitis. Brit J Nutr 103(3):393–402. Google Scholar
  73. Lavi I, Levinson D, Peri I, Tekoah Y, Hadar Y, Schwartz B (2010b) Chemical characterization, antiproliferative and antiadhesive properties of polysaccharides extracted from Pleurotus pulmonarius mycelium and fruiting bodies. Appl Microbiol Biotechnol 85(6):1977–1990. Google Scholar
  74. Lee CC, Yang HL, Way TD, Kumar KJS, Juan YC, Cho HJ, Lin KY, Hsu LS, Chen SC, Hseu YC (2012) Inhibition of cell growth and induction of apoptosis by Antrodia camphorata in HER-2/neu-overexpressing breast cancer cells through the induction of ROS, depletion of HER–2/neu, and disruption of the PI3K/Akt signaling pathway. Evid-Based Compl Alt 2012:702857
  75. Lee CI, Wu CC, Hsieh SL, Lee CL, Chang YP, Chang CC, Wang YZ, Wang JJ (2014a) Anticancer effects on human pancreatic cancer cells of triterpenoids, polysaccharides and 1,3-beta-D-glucan derived from the fruiting body of Antrodia camphorata. Food Funct 5(12):3224–3232. Google Scholar
  76. Lee TH, Chen CC, Chen JJ, Liao HF, Chang HS, Sung PJ, Tseng MH, Wang SY, Ko HH, Kuo YH (2014b) New and cytotoxic components from Antrodia camphorata. Molecules 19(12):21378–21385. Google Scholar
  77. Lee WT, Lee TH, Cheng CH, Chen KC, Chen YC, Lin CW (2015a) Antroquinonol from Antrodia camphorata suppresses breast tumor migration/invasion through inhibiting ERK-AP-1-and AKT-NF-kappa B-dependent MMP-9 and epithelial-mesenchymal transition expressions. Food Chem Toxicol 78:33–41. Google Scholar
  78. Lee YC, Ho CL, Kao WY, Chen YM (2015b) A phase I multicenter study of antroquinonol in patients with metastatic non-small-cell lung cancer who have received at least two prior systemic treatment regimens, including one platinum-based chemotherapy regimen. Mol Clin Oncol 3(6):1375–1380. Google Scholar
  79. Lee MT, Lin WC, Wang SY, Lin LJ, Yu B, Lee TT (2018) Evaluation of potential antioxidant and anti-inflammatory effects of Antrodia cinnamomea powder and the underlying molecular mechanisms via Nrf2-and NF-kappa B-dominated pathways in broiler chickens. Poultry Sci 97(7):2419–2434. Google Scholar
  80. Li TY, Chiang BH (2019) 4-Acetylantroquinonol B from Antrodia cinnamomea enhances immune function of dendritic cells against liver cancer stem cells. Biomed Pharmacother 109:2262–2269. Google Scholar
  81. Liaw CC, Chen YC, Huang GJ, Tsai YC, Chien SC, Wu JH, Wang SY, Chao LK, Sung PJ, Huang HC, Kuo YH (2013) Anti-inflammatory lanostanoids and lactone derivatives from Antrodia camphorata. J Nat Prod 76(4):489–494. Google Scholar
  82. Lien HM, Tseng CJ, Huang CL, Lin YT, Chen CC, Lai YY (2014) Antimicrobial activity of Antrodia camphorata extracts against oral bacteria. PLoS One 9(8).
  83. Lin WC, Kuo SC, YW W (2001) Effects of 28-days repeated oral administration of the fermented extract of mycelia of Antrodia camphorata (CCRC 93032) on rats. J Chin Med 12:293–303Google Scholar
  84. Lin SY, Sheen LY, Chiang BH, Yang JS, Pan JH, Chang YH, Hsu YM, Chiang JH, Lu CC, Wu CL, Chung JG (2010a) Dietary effect of Antrodia camphorata extracts on immune responses in WEHI-3 leukemia BALB/c mice. Nutr Cancer 62(5):593–600. Google Scholar
  85. Lin YW, Pan JH, Liu RH, Kuo YH, Sheen LY, Chiang BH (2010b) The 4-acetylantroquinonol B isolated from mycelium of Antrodia cinnamomea inhibits proliferation of hepatoma cells. J Sci Food Agr 90(10):1739–1744. Google Scholar
  86. Lin CJ, Rao YK, Hung CL, Feng CL, Lane HY, Tzeng DTW, Hsu PN, Lai CH, Tzeng YM (2013) Inhibition of helicobacter pylori CagA–induced pathogenesis by methylantcinate B from Antrodia camphorata. Evid–Based Compl Alt 2013:682418
  87. Lin CC, Chen CC, Kuo YH, Kuo JT, Kumar KJS, Wang SY (2015a) 2,3,5-Trimethoxy-4-cresol, an anti-metastatic constituent from the solid-state cultured mycelium of Antrodia cinnamomea and its mechanism. J Nat Med-Tokyo 69(4):513–521. Google Scholar
  88. Lin CC, Kumar KJS, Liao JW, Kuo YH, Wang SY (2015b) Genotoxic, teratotoxic and oral toxic assessments of Antrodia cinnamomea health food product (leader deluxe Antrodia cinnamomea). Toxicol Rep 2:1409–1417. Google Scholar
  89. Lin LT, Tai CJ, Su CH, Chang FM, Choong CY, Wang CK, Tai CJ (2015c) The ethanolic extract of Taiwanofungus camphoratus (Antrodia camphorata) induces cell cycle arrest and enhances cytotoxicity of cisplatin and doxorubicin on human hepatocellular carcinoma cells. Biomed Res Int 2015:415269
  90. Lin HC, Lin MH, Liao JH, Wu TH, Lee TH, Mi FL, Wu CH, Chen KC, Cheng CH, Lin CW (2017) Antroquinonol, a ubiquinone derivative from the mushroom Antrodia camphorata, inhibits colon cancer stem cell-like properties: insights into the molecular mechanism and inhibitory targets. J Agric Food Chem 65(1):51–59. Google Scholar
  91. Lin YH, Kuo JT, Chen YY, Kumar KJS, Lo CP, Lin CC, Wang SY (2018a) Immunomodulatory effects of the stout camphor medicinal mushroom, Taiwanofungus camphoratus (agaricomycetes)-based health food product in mice. Int J Med Mushrooms 20(9):849–858. Google Scholar
  92. Lin YS, Lin YY, Yang YH, Lin CL, Kuan FC, Lu CN, Chang GH, Tsai MS, Hsu CM, Yeh RA, Yang PR, Lee IY, Shu LH, Cheng YC, Liu HT, Lee KD, Chang DC, Wu CY (2018b) Antrodia cinnamomea extract inhibits the proliferation of tamoxifen-resistant breast cancer cells through apoptosis and skp2/microRNAs pathway. Bmc Complem Altern M 18.
  93. Lin IY, Chiou YS, Wu LC, Tsai CY, Chen CT, Chuang WC, Lee MC, Lin CC, Lin TT, Chen SC, Pan MH, Ma N (2019a) CCM111 prevents hepatic fibrosis via cooperative inhibition of TGF-beta, Wnt and STAT3 signaling pathways. J Food Drug Anal 27(1):184–194. Google Scholar
  94. Lin TY, Tseng AJ, Qiu WL, Chao CH, Lu MK (2019b) A sulfated glucan from Antrodia cinnamomea reduces Slug expression through regulation of TGFbeta/AKT/GSK3beta axis in lung cancer. Carbohydr Polym 210:175–184. Google Scholar
  95. Liu DZ, Liang YC, Lin SY, Lin YS, Wu WC, Hou WC, Su CH (2007) Antihypertensive activities of a solid-state culture of Taiwanofungus camphoratus (Chang-Chih) in spontaneously hypertensive rats. Biosci Biotechnol Biochem 71(1):23–30. Google Scholar
  96. Liu KJ, Leu SJ, Su CH, Chiang BL, Chen YL, Lee YL (2010) Administration of polysaccharides from Antrodia camphorata modulates dendritic cell function and alleviates allergen-induced T helper type 2 responses in a mouse model of asthma. Immunology 129(3):351–362. Google Scholar
  97. Liu FS, Yang PY, Hu DN, Huang YW, Chen MJ (2011) Antrodia camphorata induces apoptosis and enhances the cytotoxic effect of paclitaxel in human ovarian cancer cells. Int J Gynecol Cancer 21(7):1172–1179. Google Scholar
  98. Liu HY, Huang CF, Li CH, Tsai CY, Chen WH, Wei HJ, Wang MF, Kuo YH, Cheong ML, Deng WP (2016) Osteoporosis recovery by Antrodia camphorata alcohol extracts through bone regeneration in SAMP8 mice. Evid-Based Compl Alt doi.
  99. Liu F, Wang Y, Zhang K, Wang Y, Zhou R, Zeng Y, Han Y, Ng TB (2017a) A novel polysaccharide with antioxidant, HIV protease inhibiting and HIV integrase inhibiting activities from Fomitiporia punctata (P. karst.) murrill (Basidiomycota, hymenochaetales). Int J Biol Macromol 97:339–347. Google Scholar
  100. Liu Q, Zhu M, Geng X, Wang H, Ng TB (2017b) Characterization of polysaccharides with antioxidant and hepatoprotective activities from the edible mushroom Oudemansiella radicata. Molecules 22(2).
  101. Liu HW, Su YK, Bamodu OA, Hueng DY, Lee WH, Huang CC, Deng L, Hsiao M, Chien MH, Yeh CT, Lin CM (2018a) The disruption of the beta-catenin/TCF-1/STAT3 signaling axis by 4-acetylantroquinonol B inhibits the tumorigenesis and cancer stem-cell-like properties of glioblastoma cells, in vitro and in vivo. Cancers (Basel) 10(12).
  102. Liu Y, Yang A, Qu Y, Wang Z, Zhang Y, Liu Y, Wang N, Teng L, Wang D (2018b) Ameliorative effects of Antrodia cinnamomea polysaccharides against cyclophosphamide-induced immunosuppression related to Nrf2/HO-1 signaling in BALB/c mice. Int J Biol Macromol 116:8–15. Google Scholar
  103. Lu ZM, Tao WY, Zou XL, Fu HZ, Ao ZH (2007) Protective effects of mycelia of Antrodia camphorata and Armillariella tabescens in submerged culture against ethanol-induced hepatic toxicity in rats. J Ethnopharmacol 110(1):160–164. Google Scholar
  104. Lu MC, Du YC, Chuu JJ, Hwang SL, Hsieh PC, Hung CS, Chang FR, Wu YC (2009) Active extracts of wild fruiting bodies of Antrodia camphorata (EEAC) induce leukemia HL 60 cells apoptosis partially through histone hypoacetylation and synergistically promote anticancer effect of trichostatin A. Arch Toxicol 83(2):121–129. Google Scholar
  105. Lu WJ, Lin SC, Lan CC, Lee TY, Hsia CH, Huang YK, Lee HC, Sheu JR (2014) Effect of Antrodia camphorata on inflammatory arterial thrombosis-mediated platelet activation: the pivotal role of protein kinase C. Sci World J 2014:745802. Google Scholar
  106. Lu MK, Lin TY, Chang CC (2018) Chemical identification of a sulfated glucan from Antrodia cinnamomea and its anti-cancer functions via inhibition of EGFR and mTOR activity. Carbohyd Polym 202:536–544. Google Scholar
  107. Meng LM, Pai MH, Liu JJ, Yeh SL (2012) Polysaccharides from extracts of Antrodia camphorata mycelia and fruiting bodies modulate inflammatory mediator expression in mice with polymicrobial sepsis. Nutrition 28(9):942–949. Google Scholar
  108. Nakamura N, Hirakawa A, Gao JJ, Kakuda H, Shiro M, Komatsu Y, Sheu CC, Hattori M (2004) Five new maleic and succinic acid derivatives from the mycelium of Antrodia camphorata and their cytotoxic effects on LLC tumor cell line. J Nat Prod 67(1):46–48. Google Scholar
  109. Olatunji OJ, Tang J, Tola A, Auberon F, Oluwaniyi O, Ouyang Z (2018) The genus Cordyceps: an extensive review of its traditional uses, phytochemistry and pharmacology. Fitoterapia 129:293–316. Google Scholar
  110. Pan WL, Wong JH, Fang EF, Chan YS, Ye XJ, Ng TB (2013) Differential inhibitory potencies and mechanisms of the type I ribosome inactivating protein marmorin on estrogen receptor (ER)-positive and ER-negative breast cancer cells. Biochim Biophys Acta 1833(5):987–996. Google Scholar
  111. Park DK, Park HJ (2013) Ethanol extract of Antrodia camphorata grown on germinated brown rice suppresses inflammatory responses in mice with acute DSS-induced colitis. Evid-Based Compl Alt 2013:914524
  112. Peng CC, Chen KC, Peng RY, Su CH, Hsieh-Li HM (2006) Human urinary bladder cancer T24 cells are susceptible to the Antrodia camphorata extracts. Cancer Lett 243(1):109–119. Google Scholar
  113. Peng CC, Chen KC, Peng RY, Chyau CC, Su CH, Hsieh-Li HM (2007) Antrodia camphorata extract induces replicative senescence in superficial TCC, and inhibits the absolute migration capability in invasive bladder carcinoma cells. J Ethnopharmacol 109(1):93–103. Google Scholar
  114. Peng CC, Lin YT, Chen KC, Chyau CC, Peng RY (2015) Antrodan, a beta-glucan obtained from Antrodia cinnamomea mycelia, is beneficial to benign prostate hyperplasia. Food Funct 6(2):635–645. Google Scholar
  115. Perera N, Yang FL, Chang CM, Lu YT, Zhan SH, Tsai YT, Hsieh JF, Li LH, Hua KF, Wu SH (2017) Galactomannan from Antrodia cinnamomea enhances the phagocytic activity of macrophages. Org Lett 19(13):3486–3489. Google Scholar
  116. Perera N, Yang FL, Lu YT, Li LH, Hua KF, Wu SH (2018) Antrodia cinnamomea galactomannan elicits immuno-stimulatory activity through Toll-like receptor 4. Int J Biol Sci 14(10):1378–1388. Google Scholar
  117. Piotrowski J, Jedrzejewski T, Kozak W (2015) Immunomodulatory and antitumor properties of polysaccharide peptide (PSP). Postepy Hig Med Dosw 69:91–97Google Scholar
  118. Riyaphan J, Jhong CH, Lin SR, Chang CH, Tsai MJ, Lee DN, Sung PJ, Leong MK, Weng CF (2018) Hypoglycemic efficacy of docking selected natural compounds against alpha-glucosidase and alpha-amylase. Molecules 23(9).
  119. Rossi P, Difrancia R, Quagliariello V, Savino E, Tralongo P, Randazzo CL, Berretta M (2018) B-glucans from Grifola frondosa and Ganoderma lucidum in breast cancer: an example of complementary and integrative medicine. Oncotarget 9(37):24837–24856. Google Scholar
  120. Schwartz B, Hadar Y (2014) Possible mechanisms of action of mushroom-derived glucans on inflammatory bowel disease and associated cancer. Ann Transl Med 2(2):19–19. Google Scholar
  121. Shi YC, Yang SY, Lee DY, Lee C (2016) Increasing anti-A beta-induced neurotoxicity ability of Antrodia camphorata-fermented product with deep ocean water supplementary. J Sci Food Agr 96(14):4690–4701. Google Scholar
  122. Shie PH, Wang SY, Lay HL, Huang GJ (2016) 4,7-Dimethoxy-5-methyl-1,3-benzodioxole from Antrodia camphorata inhibits LPS-induced inflammation via suppression of NF-kappa B and induction HO-1 in RAW264.7 cells. Int Immunopharmacol 31:186–194. Google Scholar
  123. Song TY, Hsu SL, Yeh CT, Yen GC (2005) Mycelia from Antrodia camphorata in submerged culture induce apoptosis of human hepatoma HepG2 cells possibly through regulation of Fas pathway. J Agric Food Chem 53(14):5559–5564. Google Scholar
  124. Song AR, Qin D, Zhao C, Sun XL, Huang F, Kong C, Yang S (2014) Immunomodulatory effect of polysaccharides extracted from the medicinal mushroom Antrodia camphorata (higher Basidiomycetes) in specific pathogen-free chickens. Int J Med Mushrooms 16(1):95–103Google Scholar
  125. Sudirman S, Hsu YH, Johnson A, Tsou D, Kong ZL (2018) Amelioration effects of nanoencapsulated triterpenoids from petri dish-cultured Antrodia cinnamomea on reproductive function of diabetic male rats. Int J Nanomedicine 13:5059–5073.
  126. Sulake RS, Lin HH, Hsu CY, Weng CF, Chen C (2015) Synthesis of (+)-antroquinonol: an antihyperglycemic agent. J Org Chem 80(12):6044–6051. Google Scholar
  127. Thiyagarajan V, Tsai MJ, Weng CF (2015) Antroquinonol targets FAK-signaling pathway suppressed cell migration, invasion, and tumor growth of C6 glioma. PLoS One 10(10):e0141285. Google Scholar
  128. Tsai WC, Rao YK, Lin SS, Chou MY, Shen YT, Wu CH, Geethangili M, Yang CC, Tzeng YM (2010) Methylantcinate A induces tumor specific growth inhibition in oral cancer cells via Bax-mediated mitochondrial apoptotic pathway. Bioorg Med Chem Lett 20(20):6145–6148. Google Scholar
  129. Tsai PY, Ka SM, Chao TK, Chang JM, Lin SH, Li CY, Kuo MT, Chen P, Chen A (2011) Antroquinonol reduces oxidative stress by enhancing the Nrf2 signaling pathway and inhibits inflammation and sclerosis in focal segmental glomerulosclerosis mice. Free Radic Biol Med 50(11):1503–1516. Google Scholar
  130. Tsai PY, Ka SM, Chang JM, Lai JH, Dai MS, Jheng HL, Kuo MT, Chen P, Chen A (2012) Antroquinonol differentially modulates T cell activity and reduces interleukin-18 production, but enhances Nrf2 activation, in murine accelerated severe lupus nephritis. Arthritis Rheum 64(1):232–242. Google Scholar
  131. Tsai TC, Tung YT, Kuo YH, Liao JW, Tsai HC, Chong KY, Chen HL, Chen CM (2015) Anti-inflammatory effects of Antrodia camphorata, a herbal medicine, in a mouse skin ischemia model. J Ethnopharmacol 159:113–121. Google Scholar
  132. Tsai DH, Chung CH, Lee KT (2018) Antrodia cinnamomea induces autophagic cell death via the CHOP/TRB3/Akt/mTOR pathway in colorectal cancer cells. Sci Rep 8(1):17424. Google Scholar
  133. Tu SH, Wu CH, Chen LC, Huang CS, Chang HW, Chang CH, Lien HM, Ho YS (2012) In vivo antitumor effects of 4,7-dimethoxy-5-methyl-1,3-benzodioxole isolated from the fruiting body of Antrodia camphorata through activation of the p53-mediated p27/Kip1 signaling pathway. J Agric Food Chem 60(14):3612–3618.
  134. Wang LC, Kuo IU, Tsai TY, Lee CL (2013) Antrodia camphorata-fermented product cultured in deep ocean water has more liver protection against thioacetamide-induced fibrosis. Appl Microbiol Biotechnol 97(23):9955–9967. Google Scholar
  135. Wang SC, Lee TH, Hsu CH, Chang YJ, Chang MS, Wang YC, Ho YS, Wen WC, Lin RK (2014) Antroquinonol D, isolated from Antrodia camphorata, with DNA demethylation and anticancer potential. J Agric Food Chem 62(24):5625–5635. Google Scholar
  136. Wang YJ, Lee SC, Hsu CH, Kuo YH, Yang CC, Lin FJ (2019) Antcins, triterpenoids from Antrodia cinnamomea, as new agonists for peroxisome proliferator-activated receptor alpha. J Food Drug Anal 27(1):295–304. Google Scholar
  137. Wasser SP (2014) Medicinal mushroom science: current perspectives, advances, evidences, and challenges. Biom J 37(6):345–356. Google Scholar
  138. Wasser SP (2017) Medicinal mushrooms in human clinical studies. Part I. Anticancer, oncoimmunological, and immunomodulatory activities: a review. Int J Med Mushrooms 19(4):279–317. Google Scholar
  139. Wong JH, Ng TB, Cheung RCF, Ye XJ, Wang HX, Lam SK, Lin P, Chan YS, Fang EF, Ngai PHK, Xia LX, Ye XY, Jiang Y, Liu F (2010) Proteins with antifungal properties and other medicinal applications from plants and mushrooms. Appl Microbiol Biotechnol 87(4):1221–1235. Google Scholar
  140. Wong JH, Sze SCW, Ng TB, Cheung RCF, Tam C, Zhang KY, Dan X, Chan YS, Shing Cho WC, Ng CCW, Waye MMY, Liang W, Zhang J, Yang J, Ye X, Lin J, Ye X, Wang H, Liu F, Chan DW, Ngan HYS, Sha O, Li G, Tse R, Tse TF, Chan H (2018) Apoptosis and anti-cancer drug discovery: the power of medicinal fungi and plants. Curr Med Chem 25(40):5613–5630. Google Scholar
  141. Wu SH, Ryvarden L, Chang TT (1997) Antrodia camphorata (niu-chang-chih), new combination of a medicinal fungus in Taiwan. Bot Bull Acad Sinica 38(4):273–275Google Scholar
  142. Wu H, Pan CL, Yao YC, Chang SS, Li SL, Wu TF (2006) Proteomic analysis of the effect of Antrodia camphorata extract on human lung cancer A549 cell. Proteomics 6(3):826–835. Google Scholar
  143. Wu MT, Tzang BS, Chang YY, Chiu CH, Kang WY, Huang CH, Chen YC (2011) Effects of Antrodia camphorata on alcohol clearance and antifibrosis in livers of rats continuously fed alcohol. J Agric Food Chem 59(8):4248–4254. Google Scholar
  144. Wu MD, Cheng MJ, Yech YJ, Yuan GF, Chen JJ (2013) Inhibitory effects of maleimide derivatives from the mycelia of the fungus Antrodia cinnamomea BCRC 36799 on nitric oxide production in lipopolysaccharide (LPS)-activated RAW264.7 macrophages. Chem Biodivers 10(3):434–441. Google Scholar
  145. Wu Y, Tian WD, Gao S, Liao ZJ, Wang GH, Lo JM, Lin PH, Zeng DQ, Qiu DR, Liu XZ, Zhou M, Lin T, Chen HF (2019) Secondary metabolites of petri-dish cultured Antrodia camphorata and their hepatoprotective activities against alcohol-induced liver injury in mice. Chin J Nat Med 17(1):33–42. Google Scholar
  146. Xia Y, Chen Y, Liu X, Zhou X, Wang Z, Wang G, Xiong Z, Ai L (2019) Enhancement of antroquinonol production during batch fermentation using pH control coupled with an oxygen vector. J Sci Food Agr 99(1):449–456. Google Scholar
  147. Yang SS, Wang GJ, Wang SY, Lin YY, Kuo YH, Lee TH (2009) New constituents with iNOS inhibitory activity from mycelium of Antrodia camphorata. Planta Med 75(5):512–516. Google Scholar
  148. Yang HL, Lin KY, Juan YC, Kumar KJS, Way TD, Shen PC, Chen SC, Hseu YC (2013a) The anti-cancer activity of Antrodia camphorata against human ovarian carcinoma (SKOV-3) cells via modulation of HER-2/neu signaling pathway. J Ethnopharmacol 148(1):254–265. Google Scholar
  149. Yang PY, Hu DN, Liu FS (2013b) Cytotoxic effect and induction of apoptosis in human cervical cancer cells by Antrodia camphorata. Am J Chin Med 41(5):1169–1180. Google Scholar
  150. Yang SM, Ka SM, Hua KF, Wu TH, Chuang YP, Lin YW, Yang FL, Wu SH, Yang SS, Lin SH, Chang JM, Chen A (2013c) Antroquinonol mitigates an accelerated and progressive IgA nephropathy model in mice by activating the Nrf2 pathway and inhibiting T cells and NLRP3 inflammasome. Free Radical Bio Med 61:285–297. Google Scholar
  151. Yang PS, Lin PY, Chang CC, Yu MC, Yen TL, Lan CC, Jayakumar T, Yang CH (2015) Antrodia camphorata potentiates neuroprotection against cerebral ischemia in rats via downregulation of iNOS/HO-1/Bax and activated caspase-3 and inhibition of hydroxyl radical formation. Evid-Based Compl Alt 2015:232789
  152. Yang HL, Korivi M, Chen CH, Peng WJ, Chen CS, Li ML, Hsu LS, Liao JW, Hseu YC (2017a) Antrodia camphorata attenuates cigarette smoke-induced ROS production, DNA damage, apoptosis, and inflammation in vascular smooth muscle cells, and atherosclerosis in ApoE–deficient mice. Environ Toxicol 32(8):2070–2084.
  153. Yang KL, Chang WT, Hong MY, Hung KC, Chuang CC (2017b) Prevention of TGF-beta-induced early liver fibrosis by a maleic acid derivative antioxidant through suppression of ROS, inflammation and hepatic stellate cells activation. PLoS One 12(4).
  154. Yang SC, Huang TH, Chiu CH, Chou WL, Alalaiwe A, Yeh YC, Su KW, Fang JY (2018) The atopic dermatitis-like lesion and the associated MRSA infection and barrier dysfunction can be alleviated by 2,4-dimethoxy-6-methylbenzene-1,3-diol from Antrodia camphorata. J Dermatol Sci 92(2):188–196. Google Scholar
  155. Yeh CT, Huang WC, Rao YK, Ye M, Lee WH, Wang LS, Tzeng DTW, Wu CH, Shieh YS, Huang CYF, Chen YJ, Hsiao M, Wu ATH, Yang Z, Tzeng YM (2013) A sesquiterpene lactone antrocin from Antrodia camphorata negatively modulates JAK2/STAT3 signaling via microRNA let-7c and induces apoptosis in lung cancer cells. Carcinogenesis 34(12):2918–2928. Google Scholar
  156. Yen IC, Shi LS, Chung MC, Ahmetaj-Shala B, Chang TC, Lee SY (2018) Antrolone, a novel benzoid derived from Antrodia cinnamomea, inhibits the LPS-induced inflammatory response in RAW264.7 macrophage cells by balancing the NF-kappa B and Nrf2 pathways. Am J Chin Med 46(6):1297–1313. Google Scholar
  157. Yeung SY, Piggott MJ (2018) Reprint of: Antiproliferative activity of the Antrodia camphorata secondary metabolite 4,7-dimethoxy-5-methylbenzo [d][1,3]dioxole and analogues. Fitoterapia 126:40–44. Google Scholar
  158. Yu CC, Chiang PC, Lu PH, Kuo MT, Wen WC, Chen P, Guh JH (2012) Antroquinonol, a natural ubiquinone derivative, induces a cross talk between apoptosis, autophagy and senescence in human pancreatic carcinoma cells. J Nutr Biochem 23(8):900–907. Google Scholar
  159. Zhang Y, Li D, Wang Z, Zang W, Rao P, Liang Y, Mei Y (2018a) Alpha-terpineol affects synthesis and antitumor activity of triterpenoids from Antrodia cinnamomea mycelia in solid-state culture. Food Funct 9(12):6517–6525. Google Scholar
  160. Zhang Y, Wang Z, Li D, Zang W, Zhu H, Wu P, Mei Y, Liang Y (2018b) A polysaccharide from Antrodia cinnamomea mycelia exerts antitumor activity through blocking of TOP1/TDP1-mediated DNA repair pathway. Int J Biol Macromol 120:1551–1560. Google Scholar
  161. Zhang BB, Guan YY, Hu PF, Chen L, Xu GR, Liu L, Cheung PCK (2019) Production of bioactive metabolites by submerged fermentation of the medicinal mushroom Antrodia cinnamomea: recent advances and future development. Crit Rev Biotechnol:1–14.
  162. Zhou R, Han Y-J, Zhang M-H, Zhang K-R, Ng TB, Liu F (2017) Purification and characterization of a novel ubiquitin-like antitumour protein with hemagglutinating and deoxyribonuclease activities from the edible mushroom Ramaria botrytis. AMB Express 7.
  163. Zhou R, Liu Z, Zhang YN, Ng TB, Liu F (2018) Research progress on bioactive proteins from edible mushrooms. Curr Protein Pept Sci.
  164. Zhu PL, Fu XQ, Li JK, Tse AK, Guo H, Yin CL, Chou JY, Wang YP, Liu YX, Chen YJ, Hossen MJ, Zhang Y, Pan SY, Zhao ZJ, Yu ZL (2018) Antrodia camphorata mycelia exert anti-liver cancer effects and inhibit stat3 signaling in vitro and in vivo. Front Pharmacol 9:1449. Google Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Caicheng Wang
    • 1
    • 2
    • 3
  • Weiwei Zhang
    • 1
    • 2
    • 3
  • Jack Ho Wong
    • 4
  • Tzibun Ng
    • 4
  • Xiujuan Ye
    • 1
    • 2
    • 3
    Email author
  1. 1.State Key Laboratory of Ecological Pest Control for Fujian and Taiwan CropsFujian Agriculture and Forestry UniversityFuzhouChina
  2. 2.Key Laboratory of Biopesticide and Chemical Biology, Ministry of EducationFujian Agriculture and Forestry UniversityFuzhouChina
  3. 3.Fujian Key Laboratory of Plant Virology, Institute of Plant VirologyFujian Agriculture and Forestry UniversityFuzhouChina
  4. 4.School of Biomedical Sciences, Faculty of MedicineThe Chinese University of Hong KongShatinHong Kong, China

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