Applied Microbiology and Biotechnology

, Volume 103, Issue 8, pp 3249–3264 | Cite as

Naturally occurring of α,β-diepoxy-containing compounds: origin, structures, and biological activities

  • Vera Vil
  • Tatyana A. Gloriozova
  • Vladimir V. Poroikov
  • Alexander O. Terent’ev
  • Nick Savidov
  • Valery M. DembitskyEmail author


Diepoxy-containing compounds are widely distributed in nature. These metabolites are found in plants and marine organisms and are also produced by many microorganisms, fungi, or fungal endophytes. Many of these metabolites are antibiotics and exhibit a wide variety of biological activities. More than 80 α,β-diepoxy-containing compounds are presented in this article, which belong to different classes of chemical compounds including lipids, terpenoids, alkaloids, quinones, hydroquinones, and pyrones. The main activities that characterize α,β-diepoxy-containing compounds are antineoplastic with confidence up to 99%, antifungal with confidence up to 94%, antiinflammatory with confidence up to 92%, or antibacterial with confidence up to 78%. In addition, these metabolites can be used as a lipid metabolism regulator with a certainty of up to 81%, antiviral (Arbovirus) activity with a certainty of up to 71%, or antiallergic activity with confidence up to 69%. These data on the biological activity of diepoxy-containing compounds are of considerable interest to pharmacologists, chemists, and medical professionals who are involved in phytomedicine and related areas of science and industry.


Diepoxides Microorganisms Fungi Algae Invertebrates Plant Activities 



The work was performed in the framework of the Program for Basic Research of Russian State Academies of Sciences for 2013-2020 (Grant RFBR No. 12-04-91,445).

Compliance with ethical standards

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Conflict of interest

The authors declare that they have no competing interests.


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Authors and Affiliations

  • Vera Vil
    • 1
  • Tatyana A. Gloriozova
    • 2
  • Vladimir V. Poroikov
    • 2
  • Alexander O. Terent’ev
    • 1
  • Nick Savidov
    • 3
  • Valery M. Dembitsky
    • 1
    • 3
    • 4
    Email author
  1. 1.N.D. Zelinsky Institute of Organic ChemistryRussian Academy of SciencesMoscowRussia
  2. 2.Institute of Biomedical ChemistryRussian Academy of SciencesMoscowRussia
  3. 3.Centre for Applied Research and InnovationLethbridge CollegeLethbridgeCanada
  4. 4.National Scientific Center of Marine BiologyVladivostokRussia

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