Enrichment of cordycepin for cosmeceutical applications: culture systems and strategies

  • Phongsakorn Kunhorm
  • Nipha Chaicharoenaudomrung
  • Parinya NoisaEmail author


Cordyceps spp. is the herbal medication initially used in China and has been reported as the unique resource of cordycepin. Cordycepin exhibits many health benefits, including anti-photoaging and anti-pigmentation; therefore, it potentially is a bioactive ingredient of cosmetic products. In order to enrich cordycepin content in Cordyceps, two artificial cultivation procedures, which are solid-state fermentation and liquid culture, were developed and optimized. The aim of this review is to illustrate cordycepin biosynthesis pathway in Cordyceps, and its bioactivity for cosmeceutical applications, as well as comparing the two different cultivation procedures. The basic model of artificial cultivation of Cordyceps is introduced; meanwhile, the potential application of modern biotechnology to the artificial cultivation is also discussed. This review should be of interest to the readers for the development of cordycepin bioproduction in order to be applied in cosmeceutical industry and some other uses.


Cordyceps Cordycepin Cosmetics Solid-state fermentation Liquid culture 



This work was supported by the National Research Council of Thailand (NRCT), the Thailand Research Fund (TRF), One Research One Grant (OROG) Scholarship, Suranaree University of Technology (SUT) Research and Development Fund, and by the Office of the Higher Education Commission under the NRU Project of Thailand.

Compliance with ethical standards


There is no conflict of interest in this study.

An ethical statement

This article does not contain any studies with human participants or animals performed by any of the authors.


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© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Laboratory of Cell-Based Assays and Innovations, School of Biotechnology, Institute of Agricultural TechnologySuranaree University of TechnologyNakhon RatchasimaThailand

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