Biotransformation of dicarboxylic acids from vegetable oil–derived sources: current methods and suggestions for improvement
Sustainable manufacture of dicarboxylic acids (DCAs), which are used as raw materials for multiple commercial products, has been an area of considerable research interest in recent years. Traditional chemical-based manufacture of DCAs suffers from limitations such as harsh operational conditions and generation of hazardous by-products. Microbiological methods involving DCA production depend on the capability of alkane-assimilating microorganisms, particularly α, ω-oxidation, to metabolize alkanes. Alkanes are still used as the most common substrates for this method, but the use of renewable resources, such as vegetable oil–derived fatty acid methyl esters (FAMEs), offers multiple advantages for the sustainable production of DCA. However, DCA production using FAME, unlike that using alkanes, still has low productivity and process stability, and we have attempted to identify several limiting factors that weaken the competitiveness. This review discusses the current status and suggests solutions to various obstacles to improve the biotransformation process of FAMEs.
KeywordsDicarboxylic acids Fatty acid methyl esters Renewable resources Biotransformation ω-Oxidation Fatty acid toxicity
This research was supported by the Research Initiative Program (KGM4231713) of Korea Research Institute of Bioscience and Biotechnology, Industry Core Technology Development Project (N10047873), and Global R&D Project (N000677) of the Ministry of Trade, Industry and Energy of Korea.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflicts of interest.
This article does not contain any studies with human or animal participants performed by any of the authors.
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