Chitosan and its derivatives: synthesis, biotechnological applications, and future challenges
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Chitosan is a naturally occurring biodegradable as well as a non-toxic polymer generated from chitin through alkaline deacetylation reaction, and it is insoluble in organic/inorganic solvents and water. Furthermore, chitosan is one of the most plentiful cationic polymers in natural surroundings. Due to its non-toxicity and biocompatibility, chitosan is extensively employed in industrial, biomedical, food, pharmaceutical, environmental, and agricultural industry. Chitosan-based biomaterials exhibit great potential in various biotechnological applications, such as anti-hypertensive therapy, anti-oxidant, anti-microbial, anti-allergic, immunostimulant, cancer therapy, delivery of genetic materials, delivery of bone morphogenetic type-2, wound healing, treatment of wastewater, hypocholesterolemic, and bio-imaging. Therefore, this review mainly focuses on the biotechnological potential of chitosan and its derivatives as well as presents the potential of chitosan-based biomaterial/pharmaceutical for the prevention of various life-threating chronic disorders.
KeywordsChitosan and its derivative Biotechnological potentials Anti-cancerous Anti-oxidant Bio-imaging
The authors are very thankful to Stephan Wang for his help to revise the manuscript language.
Muhammad Shahid Riaz Rajoka, Liqing Zhao, Hafiza Mahreen Mehwish, and Wu wrote the review. All authors reviewed the manuscript.
This work was supported by the National Natural Science Foundation of China (21606152), the Natural Science Foundation of Guangdong Province (2016A030313053), and the Special Fund for Development of Strategic Emerging Industries in Shenzhen (JCYJ20160520174823939, JCYJ20170817100522830, 20170424181248489).
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
This article does not contain any studies with human participants or animals performed by any of the authors.
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