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Applied Microbiology and Biotechnology

, Volume 103, Issue 1, pp 201–209 | Cite as

Current strategies and future prospects for enhancing microbial production of citric acid

  • Wei Hu
  • Wen-jian Li
  • Hai-quan YangEmail author
  • Ji-hong ChenEmail author
Mini-Review
  • 259 Downloads

Abstract

Aspergillus niger and Yarrowia lipolytica are highly important in citric acid (CA) production. To further minimize the cost of CA bio-production using A. niger and Y. lipolytica, some strategies (e.g., metabolic engineering, efficient mutagenesis, and optimal fermentation strategies) were developed to enhance CA production and low-cost carbon sources were also utilized to decrease CA bio-production cost. In this review, we summarize the recent significant progresses in CA bio-production, including metabolic engineering, efficient mutagenesis and screening methods, optimal fermentation strategies, and use of low-cost carbon sources, and future prospects in this field are also discussed, which could help in the development of CA production industry.

Keywords

Aspergillus Niger Yarrowia lipolytica Citric acid Production Strategies 

Notes

Funding information

This work was supported financially by the National Natural Science Foundation of China (No. 11605259), the western talents program of the Chinese Academy of Sciences (Y706030XB0), and the Open Project Program of the Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, China (KLCCB-KF201802).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical statement

This article does not involve any studies with human participants performed by any of the authors.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Institute of Modern PhysicsChinese Academy of SciencesLanzhouChina
  2. 2.The Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of BiotechnologyJiangnan UniversityWuxiChina

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