Applied Microbiology and Biotechnology

, Volume 102, Issue 19, pp 8135–8143 | Cite as

Roles and applications of probiotic Lactobacillus strains

  • Zhongwang Zhang
  • Jianliang Lv
  • Li PanEmail author
  • Yongguang Zhang


Lactobacilli are recognized as probiotics on account of their health-promoting effects in the host. The aim of this review is to summarize current knowledge of the mechanisms of the adaption factors and main functions of lactobacilli that exert health-promoting effects in the host and to discuss important applications in animal and human health. The adaption mechanisms of lactobacilli facilitate interactions with the host and directly contribute to the beneficial nutritional, physiological, microbiological, and immunological effects in the host. Besides, the application of probiotic lactobacilli will increase our understanding of practical uses based on the roles of these organisms in immunoregulation, antipathogenic activities, and enhancement of the epithelial barrier.


Lactobacilli Immunoregulation Antipathogenic activities Probiotic strains Microbial homeostasis Competitive exclusion Epithelial barrier 


Funding information

This work was supported by grants from the National Key Research and Development Program of China (grant no. 2017YFD0501104), the National Natural Science Foundation of China (grant no. 31772780), the Key Technology R&D Program of Gansu Province of China (grant no. 1604NKCA045-2), and the China Agriculture Research System (grant no. CARS-35).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interests.

Ethical statement

This article references no studies with human participants or animals performed by any of the authors.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Zhongwang Zhang
    • 1
  • Jianliang Lv
    • 1
  • Li Pan
    • 1
    • 2
    Email author
  • Yongguang Zhang
    • 1
    • 2
  1. 1.State Key Laboratory of Veterinary Etiological Biology, OIE/National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research InstituteChinese Academy of Agricultural SciencesLanzhouChina
  2. 2.Jiangsu Co-innovation Center for the Prevention and Control of Important Animal Infectious Diseases and ZoonosesYangzhou UniversityYangzhouPeople’s Republic of China

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